Refined structure (8H8J) of G13 - GPR35

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 225 from structure (59.7%), 152 from model (40.3%)
Residue sidechains - 210 from structure (55.7%), 167 from model (44.3%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 A G.HN.02 AF2 AF2
G.HN 3 D G.HN.03 AF2 AF2
G.HN 4 F G.HN.04 AF2 AF2
G.HN 5 L G.HN.05 AF2 AF2
G.HN 6 P G.HN.06 AF2 AF2
G.HN 7 S G.HN.09 AF2 AF2
G.HN 8 R G.HN.10 AF2 AF2
G.HN 9 S G.HN.11 AF2 AF2
G.HN 10 V G.HN.12 AF2 AF2
G.HN 11 L G.HN.13 AF2 AF2
G.HN 12 S G.HN.14 AF2 AF2
G.HN 13 V G.HN.15 AF2 AF2
G.HN 14 C G.HN.16 AF2 AF2
G.HN 15 F G.HN.17 AF2 AF2
G.HN 16 P G.HN.18 AF2 AF2
G.HN 17 G G.HN.19 AF2 AF2
G.HN 18 C G.HN.20 AF2 AF2
G.HN 19 L G.HN.21 Structure AF2
G.HN 20 L G.HN.22 Structure Structure
G.HN 21 T G.HN.23 Structure AF2
G.HN 22 S G.HN.24 Structure AF2
G.HN 23 G G.HN.25 Structure AF2
G.HN 24 E G.HN.33 Structure AF2
G.HN 25 A G.HN.34 Structure AF2
G.HN 26 E G.HN.35 Structure AF2
G.HN 27 Q G.HN.36 Structure AF2
G.HN 28 Q G.HN.37 Structure AF2
G.HN 29 R G.HN.38 Structure AF2
G.HN 30 K G.HN.39 Structure AF2
G.HN 31 S G.HN.40 Structure Structure
G.HN 32 K G.HN.41 Structure Structure
G.HN 33 E G.HN.42 Structure AF2
G.HN 34 I G.HN.43 Structure Structure
G.HN 35 D G.HN.44 Structure Structure
G.HN 36 K G.HN.45 Structure Structure
G.HN 37 C G.HN.46 Structure Structure
G.HN 38 L G.HN.47 Structure Structure
G.HN 39 S G.HN.48 Structure Structure
G.HN 40 R G.HN.49 Structure Structure
G.HN 41 E G.HN.50 Structure Structure
G.HN 42 K G.HN.51 Structure Structure
G.HN 43 T G.HN.52 Structure Structure
G.HN 44 Y G.HN.53 Structure Structure
G.hns1 45 V G.hns1.01 Structure Structure
G.hns1 46 K G.hns1.02 Structure Structure
G.hns1 47 R G.hns1.03 Structure Structure
G.S1 48 L G.S1.01 Structure Structure
G.S1 49 V G.S1.02 Structure Structure
G.S1 50 K G.S1.03 Structure Structure
G.S1 51 I G.S1.04 Structure Structure
G.S1 52 L G.S1.05 Structure Structure
G.S1 53 L G.S1.06 Structure Structure
G.S1 54 L G.S1.07 Structure Structure
G.s1h1 55 G G.s1h1.01 Structure Structure
G.s1h1 56 A G.s1h1.02 Structure Structure
G.s1h1 57 G G.s1h1.03 Structure Structure
G.s1h1 58 E G.s1h1.04 Structure Structure
G.s1h1 59 S G.s1h1.05 Structure Structure
G.s1h1 60 G G.s1h1.06 Structure Structure
G.H1 61 K G.H1.01 Structure Structure
G.H1 62 S G.H1.02 Structure Structure
G.H1 63 T G.H1.03 Structure Structure
G.H1 64 F G.H1.04 Structure Structure
G.H1 65 L G.H1.05 Structure Structure
G.H1 66 K G.H1.06 Structure Structure
G.H1 67 Q G.H1.07 Structure Structure
G.H1 68 M G.H1.08 Structure Structure
G.H1 69 R G.H1.09 Structure Structure
G.H1 70 I G.H1.10 Structure Structure
G.H1 71 I G.H1.11 Structure Structure
G.H1 72 H G.H1.12 Structure Structure
G.h1ha 73 G G.h1ha.01 Structure Structure
G.h1ha 74 Q G.h1ha.02 AF2 AF2
G.h1ha 75 D G.h1ha.03 AF2 AF2
G.h1ha 76 F G.h1ha.04 AF2 AF2
G.h1ha 77 D G.h1ha.05 AF2 AF2
H.HA 78 Q H.HA.01 AF2 AF2
H.HA 79 R H.HA.02 AF2 AF2
H.HA 80 A H.HA.03 AF2 AF2
H.HA 81 R H.HA.04 AF2 AF2
H.HA 82 E H.HA.05 AF2 AF2
H.HA 83 E H.HA.06 AF2 AF2
H.HA 84 F H.HA.07 AF2 AF2
H.HA 85 R H.HA.08 AF2 AF2
H.HA 86 P H.HA.09 AF2 AF2
H.HA 87 T H.HA.10 AF2 AF2
H.HA 88 I H.HA.11 AF2 AF2
H.HA 89 Y H.HA.12 AF2 AF2
H.HA 90 S H.HA.13 AF2 AF2
H.HA 91 N H.HA.14 AF2 AF2
H.HA 92 V H.HA.15 AF2 AF2
H.HA 93 I H.HA.16 AF2 AF2
H.HA 94 K H.HA.17 AF2 AF2
H.HA 95 G H.HA.18 AF2 AF2
H.HA 96 M H.HA.19 AF2 AF2
H.HA 97 R H.HA.20 AF2 AF2
H.HA 98 V H.HA.21 AF2 AF2
H.HA 99 L H.HA.22 AF2 AF2
H.HA 100 V H.HA.23 AF2 AF2
H.HA 101 D H.HA.24 AF2 AF2
H.HA 102 A H.HA.25 AF2 AF2
H.HA 103 R H.HA.26 AF2 AF2
H.HA 104 E H.HA.27 AF2 AF2
H.HA 105 K H.HA.28 AF2 AF2
H.HA 106 L H.HA.29 AF2 AF2
H.hahb 107 H H.hahb.01 AF2 AF2
H.hahb 108 I H.hahb.04 AF2 AF2
H.hahb 109 P H.hahb.05 AF2 AF2
H.hahb 110 W H.hahb.06 AF2 AF2
H.hahb 111 G H.hahb.07 AF2 AF2
H.hahb 112 D H.hahb.08 AF2 AF2
H.hahb 113 N H.hahb.09 AF2 AF2
H.HB 114 S H.HB.01 AF2 AF2
H.HB 115 N H.HB.02 AF2 AF2
H.HB 116 Q H.HB.03 AF2 AF2
H.HB 117 Q H.HB.04 AF2 AF2
H.HB 118 H H.HB.05 AF2 AF2
H.HB 119 G H.HB.06 AF2 AF2
H.HB 120 D H.HB.07 AF2 AF2
H.HB 121 K H.HB.08 AF2 AF2
H.HB 122 M H.HB.09 AF2 AF2
H.HB 123 M H.HB.10 AF2 AF2
H.HB 124 S H.HB.11 AF2 AF2
H.HB 125 F H.HB.12 AF2 AF2
H.HB 126 D H.HB.13 AF2 AF2
H.HB 127 T H.HB.14 AF2 AF2
H.hbhc 128 R H.hbhc.01 AF2 AF2
H.hbhc 129 A H.hbhc.02 AF2 AF2
H.hbhc 130 P H.hbhc.03 AF2 AF2
H.hbhc 131 M H.hbhc.04 AF2 AF2
H.hbhc 132 A H.hbhc.05 AF2 AF2
H.hbhc 133 A H.hbhc.06 AF2 AF2
H.hbhc 134 Q H.hbhc.07 AF2 AF2
H.hbhc 135 G H.hbhc.08 AF2 AF2
H.hbhc 136 M H.hbhc.09 AF2 AF2
H.hbhc 137 V H.hbhc.10 AF2 AF2
H.hbhc 138 E H.hbhc.11 AF2 AF2
H.hbhc 139 T H.hbhc.12 AF2 AF2
H.hbhc 140 R H.hbhc.13 AF2 AF2
H.hbhc 141 V H.hbhc.14 AF2 AF2
H.hbhc 142 F H.hbhc.15 AF2 AF2
H.HC 143 L H.HC.01 AF2 AF2
H.HC 144 Q H.HC.02 AF2 AF2
H.HC 145 Y H.HC.03 AF2 AF2
H.HC 146 L H.HC.04 AF2 AF2
H.HC 147 P H.HC.05 AF2 AF2
H.HC 148 A H.HC.06 AF2 AF2
H.HC 149 I H.HC.07 AF2 AF2
H.HC 150 R H.HC.08 AF2 AF2
H.HC 151 A H.HC.09 AF2 AF2
H.HC 152 L H.HC.10 AF2 AF2
H.HC 153 W H.HC.11 AF2 AF2
H.HC 154 A H.HC.12 AF2 AF2
H.hchd 155 D H.hchd.01 AF2 AF2
H.HD 156 S H.HD.01 AF2 AF2
H.HD 157 G H.HD.02 AF2 AF2
H.HD 158 I H.HD.03 AF2 AF2
H.HD 159 Q H.HD.04 AF2 AF2
H.HD 160 N H.HD.05 AF2 AF2
H.HD 161 A H.HD.06 AF2 AF2
H.HD 162 Y H.HD.07 AF2 AF2
H.HD 163 D H.HD.08 AF2 AF2
H.HD 164 R H.HD.09 AF2 AF2
H.HD 165 R H.HD.10 AF2 AF2
H.HD 166 R H.HD.11 AF2 AF2
H.HD 167 E H.HD.12 AF2 AF2
H.hdhe 168 F H.hdhe.01 AF2 AF2
H.hdhe 169 Q H.hdhe.02 AF2 AF2
H.hdhe 170 L H.hdhe.03 AF2 AF2
H.hdhe 171 G H.hdhe.04 AF2 AF2
H.hdhe 172 E H.hdhe.05 AF2 AF2
H.HE 173 S H.HE.01 AF2 AF2
H.HE 174 V H.HE.02 AF2 AF2
H.HE 175 K H.HE.03 AF2 AF2
H.HE 176 Y H.HE.04 AF2 AF2
H.HE 177 F H.HE.05 AF2 AF2
H.HE 178 L H.HE.06 AF2 AF2
H.HE 179 D H.HE.07 AF2 AF2
H.HE 180 N H.HE.08 AF2 AF2
H.HE 181 L H.HE.09 AF2 AF2
H.HE 182 D H.HE.10 AF2 AF2
H.HE 183 K H.HE.11 AF2 AF2
H.HE 184 L H.HE.12 AF2 AF2
H.HE 185 G H.HE.13 AF2 AF2
H.hehf 186 E H.hehf.01 AF2 AF2
H.hehf 187 P H.hehf.02 AF2 AF2
H.hehf 188 D H.hehf.03 AF2 AF2
H.hehf 189 Y H.hehf.04 AF2 AF2
H.hehf 190 I H.hehf.05 AF2 AF2
H.hehf 191 P H.hehf.06 AF2 AF2
H.hehf 192 S H.hehf.07 AF2 AF2
H.HF 193 Q H.HF.01 AF2 AF2
H.HF 194 Q H.HF.02 AF2 AF2
H.HF 195 D H.HF.03 AF2 AF2
H.HF 196 I H.HF.04 AF2 AF2
H.HF 197 L H.HF.05 AF2 AF2
H.HF 198 L H.HF.06 AF2 AF2
G.hfs2 199 A G.hfs2.01 AF2 AF2
G.hfs2 200 R G.hfs2.02 AF2 AF2
G.hfs2 201 R G.hfs2.03 AF2 AF2
G.hfs2 202 P G.hfs2.04 AF2 AF2
G.hfs2 203 T G.hfs2.05 AF2 AF2
G.hfs2 204 K G.hfs2.06 AF2 AF2
G.hfs2 205 G G.hfs2.07 Structure Structure
G.S2 206 I G.S2.01 Structure Structure
G.S2 207 H G.S2.02 Structure Structure
G.S2 208 E G.S2.03 Structure Structure
G.S2 209 Y G.S2.04 Structure Structure
G.S2 210 D G.S2.05 Structure Structure
G.S2 211 F G.S2.06 Structure Structure
G.S2 212 E G.S2.07 Structure Structure
G.S2 213 I G.S2.08 Structure Structure
G.s2s3 214 K G.s2s3.01 Structure Structure
G.s2s3 215 N G.s2s3.02 Structure Structure
G.S3 216 V G.S3.01 Structure Structure
G.S3 217 P G.S3.02 Structure Structure
G.S3 218 F G.S3.03 Structure Structure
G.S3 219 K G.S3.04 Structure Structure
G.S3 220 M G.S3.05 Structure Structure
G.S3 221 V G.S3.06 Structure Structure
G.S3 222 D G.S3.07 Structure Structure
G.S3 223 V G.S3.08 Structure Structure
G.s3h2 224 G G.s3h2.01 Structure Structure
G.s3h2 225 G G.s3h2.02 Structure Structure
G.s3h2 226 Q G.s3h2.03 AF2 AF2
G.H2 227 R G.H2.01 AF2 AF2
G.H2 228 S G.H2.02 AF2 AF2
G.H2 229 E G.H2.03 Structure Structure
G.H2 230 R G.H2.04 Structure Structure
G.H2 231 K G.H2.05 Structure Structure
G.H2 232 R G.H2.06 Structure AF2
G.H2 233 W G.H2.07 Structure AF2
G.H2 234 F G.H2.08 Structure Structure
G.H2 235 E G.H2.09 Structure Structure
G.H2 236 C G.H2.10 Structure Structure
G.h2s4 237 F G.h2s4.01 Structure Structure
G.h2s4 238 D G.h2s4.02 Structure Structure
G.h2s4 239 S G.h2s4.03 Structure Structure
G.h2s4 240 V G.h2s4.04 Structure Structure
G.h2s4 241 T G.h2s4.05 Structure Structure
G.S4 242 S G.S4.01 Structure Structure
G.S4 243 I G.S4.02 Structure Structure
G.S4 244 L G.S4.03 Structure Structure
G.S4 245 F G.S4.04 Structure Structure
G.S4 246 L G.S4.05 Structure Structure
G.S4 247 V G.S4.06 Structure Structure
G.S4 248 S G.S4.07 Structure Structure
G.s4h3 249 S G.s4h3.01 Structure Structure
G.s4h3 250 S G.s4h3.02 Structure Structure
G.s4h3 251 E G.s4h3.03 Structure Structure
G.s4h3 252 F G.s4h3.04 Structure Structure
G.s4h3 253 D G.s4h3.05 Structure AF2
G.s4h3 254 Q G.s4h3.06 Structure Structure
G.s4h3 255 V G.s4h3.07 Structure Structure
G.s4h3 256 L G.s4h3.08 Structure Structure
G.s4h3 257 M G.s4h3.09 Structure Structure
G.s4h3 258 E G.s4h3.10 Structure Structure
G.s4h3 259 D G.s4h3.11 Structure Structure
G.s4h3 260 R G.s4h3.12 Structure Structure
G.s4h3 261 L G.s4h3.13 Structure Structure
G.s4h3 262 T G.s4h3.14 Structure Structure
G.s4h3 263 N G.s4h3.15 Structure Structure
G.H3 264 R G.H3.01 Structure Structure
G.H3 265 L G.H3.02 Structure Structure
G.H3 266 T G.H3.03 Structure Structure
G.H3 267 E G.H3.04 Structure Structure
G.H3 268 S G.H3.05 Structure Structure
G.H3 269 L G.H3.06 Structure Structure
G.H3 270 N G.H3.07 Structure Structure
G.H3 271 I G.H3.08 Structure Structure
G.H3 272 F G.H3.09 Structure Structure
G.H3 273 E G.H3.10 Structure Structure
G.H3 274 T G.H3.11 Structure Structure
G.H3 275 I G.H3.12 Structure Structure
G.H3 276 V G.H3.13 Structure Structure
G.H3 277 N G.H3.14 Structure Structure
G.H3 278 N G.H3.15 Structure Structure
G.H3 279 R G.H3.16 Structure Structure
G.H3 280 V G.H3.17 Structure Structure
G.H3 281 F G.H3.18 Structure Structure
G.h3s5 282 S G.h3s5.01 Structure Structure
G.h3s5 283 N G.h3s5.02 Structure Structure
G.h3s5 284 V G.h3s5.03 Structure Structure
G.S5 285 S G.S5.01 Structure Structure
G.S5 286 I G.S5.02 Structure Structure
G.S5 287 I G.S5.03 Structure Structure
G.S5 288 L G.S5.04 Structure Structure
G.S5 289 F G.S5.05 Structure Structure
G.S5 290 L G.S5.06 Structure Structure
G.S5 291 N G.S5.07 Structure Structure
G.s5hg 292 K G.s5hg.01 Structure Structure
G.HG 293 T G.HG.01 Structure Structure
G.HG 294 D G.HG.02 Structure Structure
G.HG 295 L G.HG.03 Structure Structure
G.HG 296 L G.HG.04 Structure Structure
G.HG 297 E G.HG.05 Structure Structure
G.HG 298 E G.HG.06 Structure Structure
G.HG 299 K G.HG.07 Structure Structure
G.HG 300 V G.HG.08 Structure Structure
G.HG 301 Q G.HG.09 Structure Structure
G.HG 302 I G.HG.12 Structure Structure
G.HG 303 V G.HG.13 Structure Structure
G.HG 304 S G.HG.14 Structure Structure
G.HG 305 I G.HG.15 Structure Structure
G.HG 306 K G.HG.16 Structure Structure
G.HG 307 D G.HG.17 Structure Structure
G.hgh4 308 Y G.hgh4.01 Structure Structure
G.hgh4 309 F G.hgh4.02 Structure Structure
G.hgh4 310 L G.hgh4.03 Structure Structure
G.hgh4 311 E G.hgh4.04 Structure Structure
G.hgh4 312 F G.hgh4.05 Structure Structure
G.hgh4 313 E G.hgh4.06 Structure Structure
G.hgh4 314 G G.hgh4.07 Structure Structure
G.hgh4 315 D G.hgh4.08 Structure Structure
G.H4 316 P G.H4.01 Structure Structure
G.H4 317 H G.H4.02 Structure Structure
G.H4 318 C G.H4.03 Structure Structure
G.H4 319 L G.H4.04 Structure Structure
G.H4 320 R G.H4.05 Structure Structure
G.H4 321 D G.H4.06 Structure Structure
G.H4 322 V G.H4.07 Structure Structure
G.H4 323 Q G.H4.08 Structure Structure
G.H4 324 K G.H4.09 Structure Structure
G.H4 325 F G.H4.10 Structure Structure
G.H4 326 L G.H4.11 Structure Structure
G.H4 327 V G.H4.12 Structure Structure
G.H4 328 E G.H4.13 Structure Structure
G.H4 329 C G.H4.14 Structure Structure
G.H4 330 F G.H4.15 Structure Structure
G.H4 331 R G.H4.16 Structure Structure
G.H4 332 N G.H4.17 Structure Structure
G.h4s6 333 K G.h4s6.01 Structure Structure
G.h4s6 334 R G.h4s6.08 Structure Structure
G.h4s6 335 R G.h4s6.09 Structure Structure
G.h4s6 336 D G.h4s6.10 Structure Structure
G.h4s6 337 Q G.h4s6.11 Structure Structure
G.h4s6 338 Q G.h4s6.12 Structure Structure
G.h4s6 339 Q G.h4s6.13 Structure Structure
G.h4s6 340 K G.h4s6.19 Structure Structure
G.h4s6 341 P G.h4s6.20 Structure Structure
G.S6 342 L G.S6.01 Structure Structure
G.S6 343 Y G.S6.02 Structure Structure
G.S6 344 H G.S6.03 Structure Structure
G.S6 345 H G.S6.04 Structure Structure
G.S6 346 F G.S6.05 Structure Structure
G.s6h5 347 T G.s6h5.01 Structure Structure
G.s6h5 348 T G.s6h5.02 Structure Structure
G.s6h5 349 A G.s6h5.03 Structure Structure
G.s6h5 350 I G.s6h5.04 Structure Structure
G.s6h5 351 N G.s6h5.05 Structure Structure
G.H5 352 T G.H5.01 Structure Structure
G.H5 353 E G.H5.02 Structure Structure
G.H5 354 N G.H5.03 Structure Structure
G.H5 355 I G.H5.04 Structure Structure
G.H5 356 R G.H5.05 Structure Structure
G.H5 357 L G.H5.06 Structure Structure
G.H5 358 V G.H5.07 Structure Structure
G.H5 359 F G.H5.08 Structure Structure
G.H5 360 R G.H5.09 Structure Structure
G.H5 361 D G.H5.10 Structure Structure
G.H5 362 V G.H5.11 Structure Structure
G.H5 363 K G.H5.12 Structure Structure
G.H5 364 D G.H5.13 Structure Structure
G.H5 365 T G.H5.14 Structure Structure
G.H5 366 I G.H5.15 Structure Structure
G.H5 367 L G.H5.16 Structure Structure
G.H5 368 H G.H5.17 Structure Structure
G.H5 369 D G.H5.18 Structure Structure
G.H5 370 N G.H5.19 Structure Structure
G.H5 371 L G.H5.20 Structure Structure
G.H5 372 K G.H5.21 Structure Structure
G.H5 373 Q G.H5.22 Structure Structure
G.H5 374 L G.H5.23 Structure Structure
G.H5 375 M G.H5.24 Structure Structure
G.H5 376 L G.H5.25 Structure Structure
G.H5 377 Q G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 283 from structure (94.3%), 17 from model (5.7%)
Residue sidechains - 280 from structure (93.3%), 20 from model (6.7%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 N - AF2 AF2
N-term 3 G - AF2 AF2
N-term 4 T - AF2 AF2
N-term 5 Y - AF2 AF2
N-term 6 N - Structure Structure
N-term 7 T - Structure Structure
N-term 8 C - Structure Structure
N-term 9 G - Structure Structure
N-term 10 S - Structure Structure
N-term 11 S - Structure Structure
N-term 12 D - Structure Structure
N-term 13 L - Structure Structure
N-term 14 T - Structure Structure
N-term 15 W - Structure Structure
TM1 16 P 1.28x28 Structure Structure
TM1 17 P 1.29x29 Structure Structure
TM1 18 A 1.30x30 Structure Structure
TM1 19 I 1.31x31 Structure Structure
TM1 20 K 1.32x32 Structure Structure
TM1 21 L 1.33x33 Structure Structure
TM1 22 G 1.34x34 Structure Structure
TM1 23 F 1.35x35 Structure Structure
TM1 24 Y 1.36x36 Structure Structure
TM1 25 A 1.37x37 Structure Structure
TM1 26 Y 1.38x38 Structure Structure
TM1 27 L 1.39x39 Structure Structure
TM1 28 G 1.40x40 Structure Structure
TM1 29 V 1.41x41 Structure Structure
TM1 30 L 1.42x42 Structure Structure
TM1 31 L 1.43x43 Structure Structure
TM1 32 V 1.44x44 Structure Structure
TM1 33 L 1.45x45 Structure Structure
TM1 34 G 1.46x46 Structure Structure
TM1 35 L 1.47x47 Structure Structure
TM1 36 L 1.48x48 Structure Structure
TM1 37 L 1.49x49 Structure Structure
TM1 38 N 1.50x50 Structure Structure
TM1 39 S 1.51x51 Structure Structure
TM1 40 L 1.52x52 Structure Structure
TM1 41 A 1.53x53 Structure Structure
TM1 42 L 1.54x54 Structure Structure
TM1 43 W 1.55x55 Structure Structure
TM1 44 V 1.56x56 Structure Structure
TM1 45 F 1.57x57 Structure Structure
TM1 46 C 1.58x58 Structure Structure
TM1 47 C 1.59x59 Structure Structure
TM1 48 R 1.60x60 Structure Structure
ICL1 49 M 12.48x48 Structure Structure
ICL1 50 Q 12.49x49 Structure Structure
ICL1 51 Q 12.50x50 Structure Structure
ICL1 52 W 12.51x51 Structure Structure
TM2 53 T 2.37x37 Structure Structure
TM2 54 E 2.38x38 Structure Structure
TM2 55 T 2.39x39 Structure Structure
TM2 56 R 2.40x40 Structure Structure
TM2 57 I 2.41x41 Structure Structure
TM2 58 Y 2.42x42 Structure Structure
TM2 59 M 2.43x43 Structure Structure
TM2 60 T 2.44x44 Structure Structure
TM2 61 N 2.45x45 Structure Structure
TM2 62 L 2.46x46 Structure Structure
TM2 63 A 2.47x47 Structure Structure
TM2 64 V 2.48x48 Structure Structure
TM2 65 A 2.49x49 Structure Structure
TM2 66 D 2.50x50 Structure Structure
TM2 67 L 2.51x51 Structure Structure
TM2 68 C 2.52x52 Structure Structure
TM2 69 L 2.53x53 Structure Structure
TM2 70 L 2.54x54 Structure Structure
TM2 71 C 2.55x55 Structure Structure
TM2 72 T 2.56x56 Structure Structure
TM2 73 L 2.57x57 Structure Structure
TM2 74 P 2.58x58 Structure Structure
TM2 75 F 2.59x59 Structure Structure
TM2 76 V 2.60x60 Structure Structure
TM2 77 L 2.61x61 Structure Structure
TM2 78 H 2.62x62 Structure Structure
TM2 79 S 2.63x63 Structure Structure
ECL1 80 L - Structure Structure
ECL1 81 R - Structure AF2
ECL1 82 D - Structure Structure
ECL1 83 T - Structure Structure
ECL1 84 S - Structure Structure
ECL1 85 D - Structure Structure
TM3 86 T 3.22x22 Structure Structure
TM3 87 P 3.23x23 Structure Structure
TM3 88 L 3.24x24 Structure Structure
TM3 89 C 3.25x25 Structure Structure
TM3 90 Q 3.26x26 Structure Structure
TM3 91 L 3.27x27 Structure Structure
TM3 92 S 3.28x28 Structure Structure
TM3 93 Q 3.29x29 Structure Structure
TM3 94 G 3.30x30 Structure Structure
TM3 95 I 3.31x31 Structure Structure
TM3 96 Y 3.32x32 Structure Structure
TM3 97 L 3.33x33 Structure Structure
TM3 98 T 3.34x34 Structure Structure
TM3 99 N 3.35x35 Structure Structure
TM3 100 R 3.36x36 Structure Structure
TM3 101 Y 3.37x37 Structure Structure
TM3 102 M 3.38x38 Structure Structure
TM3 103 S 3.39x39 Structure Structure
TM3 104 I 3.40x40 Structure Structure
TM3 105 S 3.41x41 Structure Structure
TM3 106 L 3.42x42 Structure Structure
TM3 107 V 3.43x43 Structure Structure
TM3 108 T 3.44x44 Structure Structure
TM3 109 A 3.45x45 Structure Structure
TM3 110 I 3.46x46 Structure Structure
TM3 111 A 3.47x47 Structure Structure
TM3 112 V 3.48x48 Structure Structure
TM3 113 D 3.49x49 Structure Structure
TM3 114 R 3.50x50 Structure Structure
TM3 115 Y 3.51x51 Structure Structure
TM3 116 V 3.52x52 Structure Structure
TM3 117 A 3.53x53 Structure Structure
TM3 118 V 3.54x54 Structure Structure
TM3 119 R 3.55x55 Structure Structure
TM3 120 H 3.56x56 Structure Structure
ICL2 121 P 34.50x50 Structure Structure
ICL2 122 L 34.51x51 Structure Structure
ICL2 123 R 34.52x52 Structure Structure
ICL2 124 A 34.53x53 Structure Structure
ICL2 125 R 34.54x54 Structure Structure
ICL2 126 G 34.55x55 Structure Structure
ICL2 127 L 34.56x56 Structure Structure
ICL2 128 R 34.57x57 Structure Structure
TM4 129 S 4.38x38 Structure Structure
TM4 130 P 4.39x39 Structure Structure
TM4 131 R 4.40x40 Structure Structure
TM4 132 Q 4.41x41 Structure Structure
TM4 133 A 4.42x42 Structure Structure
TM4 134 A 4.43x43 Structure Structure
TM4 135 A 4.44x44 Structure Structure
TM4 136 V 4.45x45 Structure Structure
TM4 137 C 4.46x46 Structure Structure
TM4 138 A 4.47x47 Structure Structure
TM4 139 V 4.48x48 Structure Structure
TM4 140 L 4.49x49 Structure Structure
TM4 141 W 4.50x50 Structure Structure
TM4 142 V 4.51x51 Structure Structure
TM4 143 L 4.52x52 Structure Structure
TM4 144 V 4.53x53 Structure Structure
TM4 145 I 4.54x54 Structure Structure
TM4 146 G 4.55x55 Structure Structure
TM4 147 S 4.56x56 Structure Structure
TM4 148 L 4.57x57 Structure Structure
TM4 149 V 4.58x58 Structure Structure
TM4 150 A 4.59x59 Structure Structure
TM4 151 R 4.60x60 Structure Structure
TM4 152 W 4.61x61 Structure Structure
TM4 153 L 4.62x62 Structure Structure
TM4 154 L 4.63x63 Structure Structure
TM4 155 G 4.64x64 Structure Structure
TM4 156 I 4.65x65 Structure Structure
TM4 157 Q 4.66x66 Structure AF2
TM4 158 E 4.67x67 Structure Structure
ECL2 159 G - Structure Structure
ECL2 160 G - Structure Structure
ECL2 161 F - Structure Structure
ECL2 162 C 45.50x50 Structure Structure
ECL2 163 F 45.51x51 Structure Structure
ECL2 164 R 45.52x52 Structure Structure
ECL2 165 S - Structure Structure
ECL2 166 T - Structure Structure
ECL2 167 R - Structure Structure
ECL2 168 H - Structure Structure
ECL2 169 N - Structure Structure
ECL2 170 F - Structure Structure
ECL2 171 N - Structure Structure
ECL2 172 S - Structure Structure
TM5 173 M 5.40x41 Structure Structure
TM5 174 A 5.41x42 Structure Structure
TM5 175 F 5.42x43 Structure Structure
TM5 176 P 5.43x44 Structure Structure
TM5 177 L 5.44x45 Structure Structure
TM5 178 L 5.45x46 Structure Structure
TM5 179 G 5.46x461 Structure Structure
TM5 180 F 5.47x47 Structure Structure
TM5 181 Y 5.48x48 Structure Structure
TM5 182 L 5.49x49 Structure Structure
TM5 183 P 5.50x50 Structure Structure
TM5 184 L 5.51x51 Structure Structure
TM5 185 A 5.52x52 Structure Structure
TM5 186 V 5.53x53 Structure Structure
TM5 187 V 5.54x54 Structure Structure
TM5 188 V 5.55x55 Structure Structure
TM5 189 F 5.56x56 Structure Structure
TM5 190 C 5.57x57 Structure Structure
TM5 191 S 5.58x58 Structure Structure
TM5 192 L 5.59x59 Structure Structure
TM5 193 K 5.60x60 Structure Structure
TM5 194 V 5.61x61 Structure Structure
TM5 195 V 5.62x62 Structure Structure
TM5 196 T 5.63x63 Structure Structure
TM5 197 A 5.64x64 Structure Structure
TM5 198 L 5.65x65 Structure Structure
TM5 199 A 5.66x66 Structure Structure
TM5 200 Q 5.67x67 Structure Structure
TM5 201 R 5.68x68 Structure Structure
ICL3 202 P - Structure Structure
ICL3 203 P - Structure Structure
ICL3 204 T - Structure Structure
TM6 205 D 6.23x23 Structure Structure
TM6 206 V 6.24x24 Structure Structure
TM6 207 G 6.25x25 Structure Structure
TM6 208 Q 6.26x26 Structure Structure
TM6 209 A 6.27x27 Structure Structure
TM6 210 E 6.28x28 Structure Structure
TM6 211 A 6.29x29 Structure Structure
TM6 212 T 6.30x30 Structure Structure
TM6 213 R 6.31x31 Structure Structure
TM6 214 K 6.32x32 Structure Structure
TM6 215 A 6.33x33 Structure Structure
TM6 216 A 6.34x34 Structure Structure
TM6 217 R 6.35x35 Structure Structure
TM6 218 M 6.36x36 Structure Structure
TM6 219 V 6.37x37 Structure Structure
TM6 220 W 6.38x38 Structure Structure
TM6 221 A 6.39x39 Structure Structure
TM6 222 N 6.40x40 Structure Structure
TM6 223 L 6.41x41 Structure Structure
TM6 224 L 6.42x42 Structure Structure
TM6 225 V 6.43x43 Structure Structure
TM6 226 F 6.44x44 Structure Structure
TM6 227 V 6.45x45 Structure Structure
TM6 228 V 6.46x46 Structure Structure
TM6 229 C 6.47x47 Structure Structure
TM6 230 F 6.48x48 Structure Structure
TM6 231 L 6.49x49 Structure Structure
TM6 232 P 6.50x50 Structure Structure
TM6 233 L 6.51x51 Structure Structure
TM6 234 H 6.52x52 Structure Structure
TM6 235 V 6.53x53 Structure Structure
TM6 236 G 6.54x54 Structure Structure
TM6 237 L 6.55x55 Structure Structure
TM6 238 T 6.56x56 Structure Structure
TM6 239 V 6.57x57 Structure Structure
TM6 240 R 6.58x58 Structure Structure
TM6 241 L 6.59x59 Structure Structure
TM6 242 A 6.60x60 Structure Structure
TM6 243 V 6.61x61 Structure Structure
ECL3 244 G - Structure Structure
ECL3 245 W - Structure Structure
ECL3 246 N - Structure Structure
ECL3 247 A - Structure Structure
ECL3 248 C - Structure Structure
TM7 249 A 7.26x25 Structure Structure
TM7 250 L 7.27x26 Structure Structure
TM7 251 L 7.28x27 Structure Structure
TM7 252 E 7.29x28 Structure Structure
TM7 253 T 7.30x29 Structure Structure
TM7 254 I 7.31x30 Structure Structure
TM7 255 R 7.32x31 Structure AF2
TM7 256 R 7.33x32 Structure Structure
TM7 257 A 7.34x33 Structure Structure
TM7 258 L 7.35x34 Structure Structure
TM7 259 Y 7.36x35 Structure Structure
TM7 260 I 7.37x36 Structure Structure
TM7 261 T 7.38x37 Structure Structure
TM7 262 S 7.39x38 Structure Structure
TM7 263 K 7.40x39 Structure Structure
TM7 264 L 7.41x40 Structure Structure
TM7 265 S 7.42x41 Structure Structure
TM7 266 D 7.43x42 Structure Structure
TM7 267 A 7.44x43 Structure Structure
TM7 268 N 7.45x45 Structure Structure
TM7 269 C 7.46x46 Structure Structure
TM7 270 C 7.47x47 Structure Structure
TM7 271 L 7.48x48 Structure Structure
TM7 272 D 7.49x49 Structure Structure
TM7 273 A 7.50x50 Structure Structure
TM7 274 I 7.51x51 Structure Structure
TM7 275 C 7.52x52 Structure Structure
TM7 276 Y 7.53x53 Structure Structure
TM7 277 Y 7.54x54 Structure Structure
TM7 278 Y 7.55x55 Structure Structure
TM7 279 M 7.56x56 Structure Structure
H8 280 A 8.47x47 Structure Structure
H8 281 K 8.48x48 Structure Structure
H8 282 E 8.49x49 Structure Structure
H8 283 F 8.50x50 Structure Structure
H8 284 Q 8.51x51 Structure Structure
H8 285 E 8.52x52 Structure Structure
H8 286 A 8.53x53 Structure Structure
H8 287 S 8.54x54 Structure Structure
H8 288 A 8.55x55 Structure Structure
H8 289 L 8.56x56 AF2 AF2
H8 290 A 8.57x57 AF2 AF2
C-term 291 V - AF2 AF2
C-term 292 A - AF2 AF2
C-term 293 P - AF2 AF2
C-term 294 S - AF2 AF2
C-term 295 A - AF2 AF2
C-term 296 K - AF2 AF2
C-term 297 A - AF2 AF2
C-term 298 H - AF2 AF2
C-term 299 K - AF2 AF2
C-term 300 S - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 Q 208 6x26 G.h4s6 P 341 G.h4s6.20
Van-der-waals TM6 Q 208 6x26 G.h4s6 P 341 G.h4s6.20
Hydrophobic H8 A 280 8x47 G.H5 M 375 G.H5.24
Van-der-waals H8 A 280 8x47 G.H5 M 375 G.H5.24
Hydrophobic TM1 F 45 1x57 G.H5 M 375 G.H5.24
Van-der-waals TM1 F 45 1x57 G.H5 M 375 G.H5.24
Hydrophobic H8 K 281 8x48 G.H5 Q 377 G.H5.26
Van-der-waals H8 K 281 8x48 G.H5 Q 377 G.H5.26
Hydrophobic TM3 A 117 3x53 G.H5 N 370 G.H5.19
Hydrophobic ICL2 L 122 34x51 G.H5 K 363 G.H5.12
Van-der-waals ICL2 L 122 34x51 G.H5 K 363 G.H5.12
Polar ICL2 R 125 34x54 G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 R 125 34x54 G.hns1 K 46 G.hns1.02
Van-der-waals ICL2 R 125 34x54 G.hns1 K 46 G.hns1.02
Hydrophobic TM3 V 118 3x54 G.H5 L 371 G.H5.20
Hydrophobic TM3 R 114 3x50 G.H5 L 376 G.H5.25
Van-der-waals TM3 R 114 3x50 G.H5 L 376 G.H5.25
Hydrophobic ICL2 L 122 34x51 G.S3 F 218 G.S3.03
Hydrophobic TM3 R 114 3x50 G.H5 L 374 G.H5.23
Van-der-waals TM3 R 114 3x50 G.H5 L 374 G.H5.23
Hydrophobic H8 E 282 8x49 G.H5 M 375 G.H5.24
Hydrophobic ICL2 L 122 34x51 G.S3 V 216 G.S3.01
Van-der-waals ICL2 L 122 34x51 G.S3 V 216 G.S3.01
Hydrophobic ICL3 P 202 - G.H5 R 360 G.H5.09
Van-der-waals ICL3 P 202 - G.H5 R 360 G.H5.09
Hydrophobic ICL3 T 204 - G.S6 Y 343 G.S6.02
Hydrophobic TM5 L 198 5x65 G.H5 L 371 G.H5.20
Hydrophobic TM6 M 218 6x36 G.H5 L 376 G.H5.25
Hydrophobic TM6 V 219 6x37 G.H5 L 376 G.H5.25
Hydrophobic TM5 L 198 5x65 G.H5 L 367 G.H5.16
Van-der-waals TM5 L 198 5x65 G.H5 L 367 G.H5.16
Hydrophobic ICL2 L 122 34x51 G.H5 F 359 G.H5.08
Hydrophobic TM3 V 118 3x54 G.H5 L 367 G.H5.16
Van-der-waals TM3 V 118 3x54 G.H5 L 367 G.H5.16
Hydrophobic TM2 M 59 2x43 G.H5 M 375 G.H5.24
Van-der-waals TM2 M 59 2x43 G.H5 M 375 G.H5.24
Hydrophobic ICL2 P 121 34x50 G.H5 K 363 G.H5.12
Van-der-waals ICL2 P 121 34x50 G.H5 K 363 G.H5.12
Polar TM6 Q 208 6x26 G.H5 H 368 G.H5.17
Hydrophobic TM6 Q 208 6x26 G.H5 H 368 G.H5.17
Van-der-waals TM6 Q 208 6x26 G.H5 H 368 G.H5.17
Hydrophobic ICL2 P 121 34x50 G.H5 I 366 G.H5.15
Van-der-waals ICL2 P 121 34x50 G.H5 I 366 G.H5.15
Hydrophobic TM6 A 215 6x33 G.H5 L 371 G.H5.20
Hydrophobic ICL2 L 122 34x51 G.H5 I 366 G.H5.15
Van-der-waals ICL2 L 122 34x51 G.H5 I 366 G.H5.15
Hydrophobic TM2 T 55 2x39 G.H5 L 374 G.H5.23
Van-der-waals TM2 T 55 2x39 G.H5 L 374 G.H5.23
Hydrophobic ICL2 R 125 34x54 G.H5 I 366 G.H5.15
Hydrophobic TM6 A 211 6x29 G.H5 Q 377 G.H5.26
Van-der-waals TM6 A 211 6x29 G.H5 Q 377 G.H5.26
Hydrophobic ICL3 P 202 - G.H5 D 364 G.H5.13
Van-der-waals ICL3 P 202 - G.H5 D 364 G.H5.13
Hydrophobic ICL2 R 123 34x52 G.s2s3 N 215 G.s2s3.02
Van-der-waals ICL2 R 123 34x52 G.s2s3 N 215 G.s2s3.02
Polar TM2 T 55 2x39 G.H5 Q 373 G.H5.22
Van-der-waals TM2 T 55 2x39 G.H5 Q 373 G.H5.22
Hydrophobic TM6 D 205 6x23 G.H4 R 331 G.H4.16
Hydrophobic TM2 T 55 2x39 G.H5 M 375 G.H5.24
Ionic TM5 R 201 5x68 G.H5 D 364 G.H5.13
Polar TM5 R 201 5x68 G.H5 D 364 G.H5.13
Hydrophobic TM5 R 201 5x68 G.H5 D 364 G.H5.13
Van-der-waals TM5 R 201 5x68 G.H5 D 364 G.H5.13
Hydrophobic ICL2 R 125 34x54 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 L 122 34x51 G.S1 V 49 G.S1.02
Polar ICL2 R 123 34x52 G.s2s3 K 214 G.s2s3.01
Hydrophobic ICL2 R 123 34x52 G.s2s3 K 214 G.s2s3.01
Van-der-waals ICL2 R 123 34x52 G.s2s3 K 214 G.s2s3.01
Hydrophobic TM5 R 201 5x68 G.H5 L 367 G.H5.16
Hydrophobic ICL2 R 128 34x57 G.H5 L 374 G.H5.23
Van-der-waals ICL2 R 128 34x57 G.H5 L 374 G.H5.23
Hydrophobic TM3 A 117 3x53 G.H5 L 374 G.H5.23
Hydrophobic TM6 G 207 6x25 G.h4s6 Q 338 G.h4s6.12
Van-der-waals TM6 G 207 6x25 G.h4s6 Q 338 G.h4s6.12
Hydrophobic ICL2 P 121 34x50 G.H5 L 367 G.H5.16
Hydrophobic TM3 D 113 3x49 G.H5 L 374 G.H5.23
Hydrophobic TM6 A 215 6x33 G.H5 L 376 G.H5.25
Polar TM6 Q 208 6x26 G.h4s6 Q 338 G.h4s6.12
Van-der-waals TM6 Q 208 6x26 G.h4s6 Q 338 G.h4s6.12