HCA1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.7 Å

REFERENCE

PUBLICATION DATE

Oct. 29, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

Apo (no ligand) -

PHYSIOLOGICAL LIGANDS

D-lactic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Ionic TM3 K 116 3x53 G.H5 D 350 G.H5.22
Polar TM3 K 116 3x53 G.H5 D 350 G.H5.22
Hydrophobic TM3 K 116 3x53 G.H5 D 350 G.H5.22
Van-der-waals TM3 K 116 3x53 G.H5 D 350 G.H5.22
Polar ICL3 Q 212 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 Q 212 - G.h4s6 E 318 G.h4s6.12
Polar C-term S 282 - G.H5 G 352 G.H5.24
Hydrophobic C-term S 282 - G.H5 G 352 G.H5.24
Van-der-waals C-term S 282 - G.H5 G 352 G.H5.24
Hydrophobic C-term P 283 - G.H5 F 354 G.H5.26
Hydrophobic ICL2 P 120 - G.H5 I 344 G.H5.16
Hydrophobic ICL3 Q 208 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 Q 208 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 R 113 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 M 215 6x30 G.H5 L 348 G.H5.20
Hydrophobic TM6 A 218 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 120 - G.H5 T 340 G.H5.12
Hydrophobic ICL3 L 209 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 L 209 - G.H5 K 345 G.H5.17
Hydrophobic TM6 I 222 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL2 T 126 - G.hns1 R 32 G.hns1.03
Polar ICL2 P 120 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 120 - G.H5 N 347 G.H5.19
Polar C-term S 284 - G.H5 G 352 G.H5.24
Hydrophobic ICL3 L 209 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 L 209 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 Q 208 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 Q 208 - G.S6 Y 320 G.S6.02
Hydrophobic TM5 R 206 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 206 5x68 G.H5 I 344 G.H5.16
Polar TM2 S 50 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 S 50 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 S 50 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 K 48 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 K 48 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM3 V 117 3x54 G.H5 L 348 G.H5.20
Polar TM3 K 116 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 K 116 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 K 116 3x53 G.H5 N 347 G.H5.19
Ionic TM5 R 206 5x68 G.H5 D 341 G.H5.13
Hydrophobic ICL2 H 121 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 H 121 - G.H5 I 343 G.H5.15
Hydrophobic TM3 R 113 3x50 G.H5 C 351 G.H5.23
Polar ICL2 H 121 - G.H5 T 340 G.H5.12
Hydrophobic ICL2 H 121 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 H 121 - G.H5 T 340 G.H5.12
Hydrophobic TM3 K 116 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 K 116 3x53 G.H5 C 351 G.H5.23
Aromatic TM6 R 214 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 214 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 214 6x29 G.H5 F 354 G.H5.26
Polar C-term S 282 - G.H5 L 353 G.H5.25
Hydrophobic C-term F 285 - G.H5 G 352 G.H5.24
Van-der-waals C-term F 285 - G.H5 G 352 G.H5.24
Hydrophobic C-term F 285 - G.H5 C 351 G.H5.23
Aromatic ICL2 H 121 - G.H5 F 336 G.H5.08
Hydrophobic ICL2 H 121 - G.H5 F 336 G.H5.08
Van-der-waals ICL2 H 121 - G.H5 F 336 G.H5.08
Hydrophobic ICL3 L 209 - G.H5 I 344 G.H5.16
Polar TM3 D 112 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 D 112 3x49 G.H5 C 351 G.H5.23
Van-der-waals TM3 D 112 3x49 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 120 - G.H5 I 343 G.H5.15
Polar TM2 S 50 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM2 S 50 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 S 50 2x39 G.H5 D 350 G.H5.22
Hydrophobic ICL2 H 121 - G.S3 L 194 G.S3.01