Refined structure (7VKT) of Gi1 - BLT1 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

3D VIEW

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 227 from structure (64.1%), 127 from model (35.9%)
Residue sidechains - 223 from structure (63.0%), 131 from model (37.0%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 Structure Structure
G.HN 3 C G.HN.09 Structure Structure
G.HN 4 T G.HN.10 Structure Structure
G.HN 5 L G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure AF2
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 Structure Structure
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure Structure
G.s2s3 193 D G.s2s3.02 Structure Structure
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure Structure
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure Structure
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure Structure
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure Structure
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure Structure
G.H2 210 K G.H2.06 Structure Structure
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure Structure
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure Structure
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure Structure
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure Structure
G.s4h3 234 L G.s4h3.08 Structure Structure
G.s4h3 235 A G.s4h3.09 Structure Structure
G.s4h3 236 E G.s4h3.10 Structure Structure
G.s4h3 237 D G.s4h3.11 Structure Structure
G.s4h3 238 E G.s4h3.12 Structure Structure
G.s4h3 239 E G.s4h3.13 Structure Structure
G.s4h3 240 M G.s4h3.14 Structure Structure
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure AF2
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure Structure
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure Structure
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure Structure
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure Structure
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure Structure
G.HG 276 E G.HG.06 Structure Structure
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure Structure
G.HG 280 K G.HG.12 Structure Structure
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure Structure
G.hgh4 290 Y G.hgh4.05 Structure Structure
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure Structure
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure Structure
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure Structure
G.h4s6 316 T G.h4s6.10 Structure Structure
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure Structure
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure Structure
G.s6h5 328 D G.s6h5.05 Structure Structure
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure Structure
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 286 from structure (93.5%), 20 from model (6.5%)
Residue sidechains - 283 from structure (92.5%), 23 from model (7.5%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 N - AF2 AF2
N-term 3 T - AF2 AF2
N-term 4 T - AF2 AF2
N-term 5 S - AF2 AF2
N-term 6 S - AF2 AF2
N-term 7 A - AF2 AF2
N-term 8 A - AF2 AF2
N-term 9 P - AF2 AF2
N-term 10 P - AF2 AF2
N-term 11 S - AF2 AF2
N-term 12 L - AF2 AF2
TM1 13 G 1.27x27 AF2 AF2
TM1 14 V 1.28x28 AF2 AF2
TM1 15 E 1.29x29 AF2 AF2
TM1 16 F 1.30x30 Structure Structure
TM1 17 I 1.31x31 Structure Structure
TM1 18 S 1.32x32 Structure Structure
TM1 19 L 1.33x33 Structure Structure
TM1 20 L 1.34x34 Structure Structure
TM1 21 A 1.35x35 Structure Structure
TM1 22 I 1.36x36 Structure Structure
TM1 23 I 1.37x37 Structure Structure
TM1 24 L 1.38x38 Structure Structure
TM1 25 L 1.39x39 Structure Structure
TM1 26 S 1.40x40 Structure Structure
TM1 27 V 1.41x41 Structure Structure
TM1 28 A 1.42x42 Structure Structure
TM1 29 L 1.43x43 Structure Structure
TM1 30 A 1.44x44 Structure Structure
TM1 31 V 1.45x45 Structure Structure
TM1 32 G 1.46x46 Structure Structure
TM1 33 L 1.47x47 Structure Structure
TM1 34 P 1.48x48 Structure Structure
TM1 35 G 1.49x49 Structure Structure
TM1 36 N 1.50x50 Structure Structure
TM1 37 S 1.51x51 Structure Structure
TM1 38 F 1.52x52 Structure Structure
TM1 39 V 1.53x53 Structure Structure
TM1 40 V 1.54x54 Structure Structure
TM1 41 W 1.55x55 Structure Structure
TM1 42 S 1.56x56 Structure Structure
TM1 43 I 1.57x57 Structure Structure
TM1 44 L 1.58x58 Structure Structure
TM1 45 K 1.59x59 Structure Structure
TM1 46 R 1.60x60 Structure Structure
ICL1 47 M 12.48x48 Structure Structure
ICL1 48 Q 12.49x49 Structure Structure
ICL1 49 K 12.50x50 Structure Structure
ICL1 50 R 12.51x51 Structure Structure
TM2 51 S 2.37x37 Structure Structure
TM2 52 V 2.38x38 Structure Structure
TM2 53 T 2.39x39 Structure Structure
TM2 54 A 2.40x40 Structure Structure
TM2 55 L 2.41x41 Structure Structure
TM2 56 M 2.42x42 Structure Structure
TM2 57 V 2.43x43 Structure Structure
TM2 58 L 2.44x44 Structure Structure
TM2 59 N 2.45x45 Structure Structure
TM2 60 L 2.46x46 Structure Structure
TM2 61 A 2.47x47 Structure Structure
TM2 62 L 2.48x48 Structure Structure
TM2 63 A 2.49x49 Structure Structure
TM2 64 D 2.50x50 Structure Structure
TM2 65 L 2.51x51 Structure Structure
TM2 66 A 2.52x52 Structure Structure
TM2 67 V 2.53x53 Structure Structure
TM2 68 L 2.54x54 Structure Structure
TM2 69 L 2.55x55 Structure Structure
TM2 70 T 2.56x56 Structure Structure
TM2 71 A 2.57x57 Structure Structure
TM2 72 P 2.58x58 Structure Structure
TM2 73 F 2.59x59 Structure Structure
TM2 74 F 2.60x60 Structure Structure
TM2 75 L 2.61x61 Structure Structure
TM2 76 H 2.62x62 Structure Structure
TM2 77 F 2.63x63 Structure Structure
TM2 78 L 2.64x64 Structure Structure
TM2 79 A 2.65x65 Structure Structure
TM2 80 Q 2.66x66 Structure Structure
TM2 81 G 2.67x67 Structure Structure
ECL1 82 T 23.49x49 Structure Structure
ECL1 83 W 23.50x50 Structure Structure
ECL1 84 S 23.51x51 Structure Structure
ECL1 85 F 23.52x52 Structure Structure
TM3 86 G 3.21x21 Structure Structure
TM3 87 L 3.22x22 Structure Structure
TM3 88 A 3.23x23 Structure Structure
TM3 89 G 3.24x24 Structure Structure
TM3 90 C 3.25x25 Structure Structure
TM3 91 R 3.26x26 Structure Structure
TM3 92 L 3.27x27 Structure Structure
TM3 93 C 3.28x28 Structure Structure
TM3 94 H 3.29x29 Structure Structure
TM3 95 Y 3.30x30 Structure Structure
TM3 96 V 3.31x31 Structure Structure
TM3 97 C 3.32x32 Structure Structure
TM3 98 G 3.33x33 Structure Structure
TM3 99 V 3.34x34 Structure Structure
TM3 100 S 3.35x35 Structure Structure
TM3 101 M 3.36x36 Structure Structure
TM3 102 Y 3.37x37 Structure Structure
TM3 103 A 3.38x38 Structure Structure
TM3 104 S 3.39x39 Structure Structure
TM3 105 V 3.40x40 Structure Structure
TM3 106 L 3.41x41 Structure AF2
TM3 107 L 3.42x42 Structure Structure
TM3 108 I 3.43x43 Structure Structure
TM3 109 T 3.44x44 Structure Structure
TM3 110 A 3.45x45 Structure Structure
TM3 111 M 3.46x46 Structure Structure
TM3 112 S 3.47x47 Structure Structure
TM3 113 L 3.48x48 Structure Structure
TM3 114 D 3.49x49 Structure Structure
TM3 115 R 3.50x50 Structure Structure
TM3 116 S 3.51x51 Structure Structure
TM3 117 L 3.52x52 Structure Structure
TM3 118 A 3.53x53 Structure Structure
TM3 119 V 3.54x54 Structure Structure
TM3 120 A 3.55x55 Structure Structure
TM3 121 R 3.56x56 Structure Structure
ICL2 122 P 34.50x50 Structure Structure
ICL2 123 F 34.51x51 Structure Structure
ICL2 124 V 34.52x52 Structure Structure
ICL2 125 S 34.53x53 Structure Structure
ICL2 126 Q 34.54x54 Structure Structure
ICL2 127 K 34.55x55 Structure Structure
ICL2 128 L 34.56x56 Structure Structure
ICL2 129 R 34.57x57 Structure Structure
TM4 130 T 4.38x38 Structure Structure
TM4 131 K 4.39x39 Structure Structure
TM4 132 A 4.40x40 Structure Structure
TM4 133 M 4.41x41 Structure Structure
TM4 134 A 4.42x42 Structure Structure
TM4 135 R 4.43x43 Structure Structure
TM4 136 R 4.44x44 Structure Structure
TM4 137 V 4.45x45 Structure Structure
TM4 138 L 4.46x46 Structure Structure
TM4 139 A 4.47x47 Structure Structure
TM4 140 G 4.48x48 Structure Structure
TM4 141 I 4.49x49 Structure Structure
TM4 142 W 4.50x50 Structure Structure
TM4 143 V 4.51x51 Structure Structure
TM4 144 L 4.52x52 Structure Structure
TM4 145 S 4.53x53 Structure Structure
TM4 146 F 4.54x54 Structure Structure
TM4 147 L 4.55x55 Structure Structure
TM4 148 L 4.56x56 Structure Structure
TM4 149 A 4.57x57 Structure Structure
TM4 150 T 4.58x59 Structure Structure
TM4 151 P 4.59x60 Structure Structure
TM4 152 V 4.60x61 Structure Structure
TM4 153 L 4.61x62 Structure Structure
TM4 154 A 4.62x63 Structure Structure
TM4 155 Y 4.63x64 Structure Structure
TM4 156 R 4.64x65 Structure Structure
ECL2 157 T - Structure Structure
ECL2 158 V - Structure Structure
ECL2 159 V - Structure Structure
ECL2 160 P - Structure Structure
ECL2 161 W - Structure Structure
ECL2 162 K - Structure Structure
ECL2 163 T - Structure Structure
ECL2 164 N - Structure Structure
ECL2 165 M - Structure Structure
ECL2 166 S - Structure Structure
ECL2 167 L - Structure Structure
ECL2 168 C 45.50x50 Structure Structure
ECL2 169 F 45.51x51 Structure Structure
ECL2 170 P 45.52x52 Structure Structure
ECL2 171 R - Structure Structure
ECL2 172 Y - Structure Structure
ECL2 173 P - Structure Structure
TM5 174 S 5.31x32 Structure Structure
TM5 175 E 5.32x33 Structure Structure
TM5 176 G 5.33x34 Structure Structure
TM5 177 H 5.34x35 Structure Structure
TM5 178 R 5.35x36 Structure Structure
TM5 179 A 5.36x37 Structure Structure
TM5 180 F 5.37x38 Structure Structure
TM5 181 H 5.38x39 Structure Structure
TM5 182 L 5.39x40 Structure Structure
TM5 183 I 5.40x41 Structure Structure
TM5 184 F 5.41x42 Structure Structure
TM5 185 E 5.42x43 Structure Structure
TM5 186 A 5.43x44 Structure Structure
TM5 187 V 5.44x45 Structure Structure
TM5 188 T 5.45x46 Structure Structure
TM5 189 G 5.46x461 Structure Structure
TM5 190 F 5.47x47 Structure Structure
TM5 191 L 5.48x48 Structure Structure
TM5 192 L 5.49x49 Structure Structure
TM5 193 P 5.50x50 Structure Structure
TM5 194 F 5.51x51 Structure Structure
TM5 195 L 5.52x52 Structure Structure
TM5 196 A 5.53x53 Structure AF2
TM5 197 V 5.54x54 Structure Structure
TM5 198 V 5.55x55 Structure Structure
TM5 199 A 5.56x56 Structure Structure
TM5 200 S 5.57x57 Structure Structure
TM5 201 Y 5.58x58 Structure Structure
TM5 202 S 5.59x59 Structure Structure
TM5 203 D 5.60x60 Structure Structure
TM5 204 I 5.61x61 Structure Structure
TM5 205 G 5.62x62 Structure Structure
TM5 206 R 5.63x63 Structure Structure
TM5 207 R 5.64x64 Structure Structure
TM5 208 L 5.65x65 Structure Structure
TM5 209 Q 5.66x66 Structure Structure
TM5 210 A 5.67x67 Structure Structure
TM5 211 R 5.68x68 Structure Structure
ICL3 212 R - Structure Structure
ICL3 213 F - Structure Structure
ICL3 214 R - Structure Structure
ICL3 215 R - Structure Structure
TM6 216 S 6.30x30 Structure Structure
TM6 217 R 6.31x31 Structure Structure
TM6 218 R 6.32x32 Structure Structure
TM6 219 T 6.33x33 Structure Structure
TM6 220 G 6.34x34 Structure Structure
TM6 221 R 6.35x35 Structure Structure
TM6 222 L 6.36x36 Structure Structure
TM6 223 V 6.37x37 Structure Structure
TM6 224 V 6.38x38 Structure Structure
TM6 225 L 6.39x39 Structure Structure
TM6 226 I 6.40x40 Structure Structure
TM6 227 I 6.41x41 Structure Structure
TM6 228 L 6.42x42 Structure Structure
TM6 229 T 6.43x43 Structure Structure
TM6 230 F 6.44x44 Structure Structure
TM6 231 A 6.45x45 Structure Structure
TM6 232 A 6.46x46 Structure Structure
TM6 233 F 6.47x47 Structure Structure
TM6 234 W 6.48x48 Structure Structure
TM6 235 L 6.49x49 Structure Structure
TM6 236 P 6.50x50 Structure Structure
TM6 237 Y 6.51x51 Structure Structure
TM6 238 H 6.52x52 Structure Structure
TM6 239 V 6.53x53 Structure Structure
TM6 240 V 6.54x54 Structure Structure
TM6 241 N 6.55x55 Structure Structure
TM6 242 L 6.56x56 Structure Structure
TM6 243 A 6.57x57 Structure Structure
TM6 244 E 6.58x58 Structure Structure
TM6 245 A 6.59x59 Structure Structure
TM6 246 G 6.60x60 Structure Structure
TM6 247 R 6.61x61 Structure Structure
TM6 248 A 6.62x62 Structure Structure
TM6 249 L 6.63x63 Structure Structure
TM6 250 A 6.64x64 Structure Structure
TM6 251 G 6.65x65 Structure Structure
ECL3 252 Q - Structure Structure
ECL3 253 A - Structure Structure
ECL3 254 A - Structure Structure
ECL3 255 G - Structure Structure
ECL3 256 L - Structure Structure
TM7 257 G 7.25x24 Structure Structure
TM7 258 L 7.26x25 Structure Structure
TM7 259 V 7.27x26 Structure Structure
TM7 260 G 7.28x27 Structure Structure
TM7 261 K 7.29x28 Structure Structure
TM7 262 R 7.30x29 Structure Structure
TM7 263 L 7.31x30 Structure Structure
TM7 264 S 7.32x31 Structure Structure
TM7 265 L 7.33x32 Structure Structure
TM7 266 A 7.34x33 Structure Structure
TM7 267 R 7.35x34 Structure Structure
TM7 268 N 7.36x35 Structure Structure
TM7 269 V 7.37x36 Structure Structure
TM7 270 L 7.38x37 Structure Structure
TM7 271 I 7.39x38 Structure Structure
TM7 272 A 7.40x39 Structure Structure
TM7 273 L 7.41x40 Structure Structure
TM7 274 A 7.42x41 Structure Structure
TM7 275 F 7.43x42 Structure Structure
TM7 276 L 7.44x43 Structure Structure
TM7 277 S 7.45x45 Structure Structure
TM7 278 S 7.46x46 Structure Structure
TM7 279 S 7.47x47 Structure Structure
TM7 280 V 7.48x48 Structure Structure
TM7 281 N 7.49x49 Structure Structure
TM7 282 P 7.50x50 Structure Structure
TM7 283 V 7.51x51 Structure Structure
TM7 284 L 7.52x52 Structure Structure
TM7 285 Y 7.53x53 Structure Structure
TM7 286 A 7.54x54 Structure Structure
TM7 287 C 7.55x55 Structure AF2
TM7 288 A 7.56x56 Structure Structure
TM7 289 G 7.57x57 Structure Structure
TM7 290 G 7.58x58 Structure Structure
TM7 291 G 7.59x59 Structure Structure
TM7 292 L 7.60x60 Structure Structure
TM7 293 L 7.61x61 Structure Structure
TM7 294 R 7.62x62 Structure Structure
TM7 295 S 7.63x63 Structure Structure
TM7 296 A 7.64x64 Structure Structure
C-term 297 G - Structure Structure
C-term 298 V - Structure Structure
C-term 299 G - Structure Structure
C-term 300 F - Structure Structure
C-term 301 V - Structure Structure
C-term 302 A - AF2 AF2
C-term 303 K - AF2 AF2
C-term 304 L - AF2 AF2
C-term 305 L - AF2 AF2
C-term 306 E - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 208 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 F 123 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 F 123 34x51 G.H5 I 343 G.H5.15
Ionic ICL3 R 212 - G.H5 D 341 G.H5.13
Polar ICL3 R 212 - G.H5 D 341 G.H5.13
Ionic TM5 R 211 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 211 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 211 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM7 G 291 7x59 G.H5 L 353 G.H5.25
Hydrophobic TM7 G 291 7x59 G.H5 G 352 G.H5.24
Van-der-waals TM7 G 291 7x59 G.H5 G 352 G.H5.24
Polar TM3 R 115 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 115 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 115 3x50 G.H5 C 351 G.H5.23
Polar TM6 R 217 6x31 G.H5 F 354 G.H5.26
Aromatic TM6 R 217 6x31 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 217 6x31 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 217 6x31 G.H5 F 354 G.H5.26
Hydrophobic TM3 A 118 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 118 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 F 123 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 F 123 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM5 R 211 5x68 G.H5 I 344 G.H5.16
Polar TM2 T 53 2x39 G.H5 D 350 G.H5.22
Polar TM3 A 118 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 118 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 118 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 Q 126 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 R 212 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 R 212 - G.S6 Y 320 G.S6.02
Polar ICL2 P 122 34x50 G.H5 N 347 G.H5.19
Hydrophobic TM6 T 219 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 219 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 122 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL2 P 122 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL3 R 215 - G.H5 F 354 G.H5.26
Hydrophobic ICL2 K 127 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM7 G 290 7x58 G.H5 F 354 G.H5.26
Hydrophobic TM3 V 119 3x54 G.H5 I 344 G.H5.16
Polar TM4 T 130 4x38 G.HN E 28 G.HN.52
Hydrophobic TM3 V 119 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 119 3x54 G.H5 L 348 G.H5.20
Polar TM7 G 290 7x58 G.H5 L 353 G.H5.25
Hydrophobic TM7 G 290 7x58 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 115 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL3 F 213 - G.H5 K 345 G.H5.17
Hydrophobic TM7 G 291 7x59 G.H5 F 354 G.H5.26
Van-der-waals TM7 G 291 7x59 G.H5 F 354 G.H5.26
Polar ICL2 R 129 34x57 G.H5 C 351 G.H5.23
Hydrophobic ICL2 R 129 34x57 G.H5 C 351 G.H5.23
Van-der-waals ICL2 R 129 34x57 G.H5 C 351 G.H5.23
Hydrophobic TM6 T 219 6x33 G.H5 F 354 G.H5.26
Polar TM3 D 114 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 D 114 3x49 G.H5 C 351 G.H5.23
Van-der-waals TM3 D 114 3x49 G.H5 C 351 G.H5.23
Polar TM6 R 218 6x32 G.H5 F 354 G.H5.26
Aromatic TM6 R 218 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 218 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 218 6x32 G.H5 F 354 G.H5.26