FFA4 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.1 Å

REFERENCE

PUBLICATION DATE

March 15, 2023

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

9-Hydroxyoctadecanoic acid - Agonist pubchem

ENDOGENOUS LIGANDS

linoleic acid, oleic acid, α-linolenic acid, myristic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL2 R 145 - G.H5 I 343 G.H5.15
Hydrophobic TM3 I 140 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 I 140 3x54 G.H5 N 347 G.H5.19
Hydrophobic ICL2 G 146 - G.S3 L 194 G.S3.01
Polar TM6 S 248 6x20 G.H4 E 308 G.H4.16
Hydrophobic TM6 Q 258 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 Q 258 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 S 248 6x20 G.H4 E 308 G.H4.16
Hydrophobic TM3 R 136 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM5 R 238 5x69 G.H5 K 345 G.H5.17
Hydrophobic ICL1 T 74 - G.H5 C 351 G.H5.23
Van-der-waals TM3 R 136 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 G 146 - G.H5 I 343 G.H5.15
Hydrophobic TM5 L 241 5x72 G.H5 D 337 G.H5.09
Van-der-waals TM5 L 241 5x72 G.H5 D 337 G.H5.09
Hydrophobic TM6 L 262 6x34 G.H5 L 348 G.H5.20
Hydrophobic TM6 S 248 6x20 G.H4 Q 304 G.H4.12
Hydrophobic TM5 L 241 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 L 241 5x72 G.H5 D 341 G.H5.13
Polar C-term T 324 - G.H5 G 352 G.H5.24
Van-der-waals TM6 H 251 6x23 G.H4 E 308 G.H4.16
Hydrophobic ICL3 A 246 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 A 246 - G.H5 F 334 G.H5.06
Hydrophobic TM5 L 241 5x72 G.H5 A 338 G.H5.10
Hydrophobic TM6 L 269 6x41 G.H5 L 353 G.H5.25
Hydrophobic TM6 R 261 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 261 6x33 G.H5 F 354 G.H5.26
Hydrophobic ICL2 G 146 - G.S1 V 34 G.S1.02
Hydrophobic ICL2 G 146 - G.hns1 R 32 G.hns1.03
Hydrophobic TM6 L 262 6x34 G.H5 L 353 G.H5.25
Polar TM3 R 136 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 136 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 136 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM5 I 233 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM6 L 262 6x34 G.H5 F 354 G.H5.26
Hydrophobic TM5 I 230 5x61 G.H5 L 348 G.H5.20
Polar TM5 S 237 5x68 G.H5 D 341 G.H5.13
Polar ICL2 G 146 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 G 146 - G.hns1 A 31 G.hns1.02
Hydrophobic TM6 R 254 6x26 G.h4s6 K 314 G.h4s6.08
Hydrophobic ICL3 A 246 - G.S6 Y 320 G.S6.02
Hydrophobic TM3 I 140 3x54 G.H5 I 344 G.H5.16
Polar TM5 R 240 5x71 G.H5 T 340 G.H5.12
Van-der-waals TM5 R 240 5x71 G.H5 T 340 G.H5.12
Polar ICL3 Y 247 - G.H5 D 341 G.H5.13
Hydrophobic TM3 I 140 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 140 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM6 R 254 6x26 G.h4s6 K 314 G.h4s6.08
Ionic TM5 R 238 5x69 G.H5 D 341 G.H5.13
Hydrophobic TM3 C 139 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 L 143 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 143 - G.H5 I 343 G.H5.15
Ionic TM6 R 254 6x26 G.H4 E 308 G.H4.16
Polar TM6 R 254 6x26 G.H4 E 308 G.H4.16
Hydrophobic ICL1 A 73 - G.H5 D 350 G.H5.22
Van-der-waals ICL1 A 73 - G.H5 D 350 G.H5.22
Hydrophobic ICL2 L 143 - G.H5 I 344 G.H5.16
Hydrophobic ICL2 Q 144 - G.H5 N 347 G.H5.19
Hydrophobic TM5 I 230 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM5 S 237 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM5 S 244 5x75 G.H5 F 334 G.H5.06
Van-der-waals TM5 S 244 5x75 G.H5 F 334 G.H5.06
Polar TM3 C 139 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 C 139 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM5 L 241 5x72 G.S6 Y 320 G.S6.02
Hydrophobic TM5 L 241 5x72 G.H5 F 334 G.H5.06
Hydrophobic TM6 H 251 6x23 G.h4s6 E 318 G.h4s6.12
Polar C-term T 324 - G.H5 F 354 G.H5.26
Van-der-waals C-term T 324 - G.H5 F 354 G.H5.26
Hydrophobic ICL1 R 71 - G.H5 D 350 G.H5.22
Hydrophobic TM6 L 266 6x38 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 266 6x38 G.H5 L 353 G.H5.25
Ionic TM5 R 240 5x71 G.H5 D 337 G.H5.09
Polar TM5 R 240 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM5 R 240 5x71 G.H5 D 337 G.H5.09