D2 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

6VMS

RESOLUTION

3.8 Å

REFERENCE

10.1038/S41586-020-2379-5

PUBLICATION DATE

June 17, 2020

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

51 interactions (Click to see)

LIGANDS

bromocriptine - Agonist pubchem gtoplig chembl_ligand drugbank drug_central

PHYSIOLOGICAL LIGANDS

dopamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 R 132 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 132 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 136 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 136 3x54 G.H5 L 348 G.H5.20
Ionic TM6 K 362 6x24 G.h4s6 D 315 G.h4s6.09
Polar TM6 K 362 6x24 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 K 362 6x24 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 K 362 6x24 G.h4s6 D 315 G.h4s6.09
Polar TM6 Q 366 6x28 G.H5 F 354 G.H5.26
Hydrophobic TM6 Q 366 6x28 G.H5 F 354 G.H5.26
Van-der-waals TM6 Q 366 6x28 G.H5 F 354 G.H5.26
Polar H8 N 430 8x47 G.H5 K 349 G.H5.21
Polar TM2 T 69 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM6 K 367 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 367 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM4 Y 146 4x36 G.HN E 28 G.HN.52
Hydrophobic TM5 I 212 5x61 G.H5 L 353 G.H5.25
Ionic TM5 R 219 5x68 G.H5 D 337 G.H5.09
Polar ICL2 Y 142 - G.H5 C 351 G.H5.23
Hydrophobic ICL2 Y 142 - G.H5 C 351 G.H5.23
Hydrophobic TM6 L 374 6x36 G.H5 L 353 G.H5.25
Polar ICL2 N 143 - G.H5 N 347 G.H5.19
Hydrophobic TM4 Y 146 4x36 G.hns1 A 31 G.hns1.02
Polar TM6 K 367 6x29 G.H5 L 353 G.H5.25
Hydrophobic TM4 Y 146 4x36 G.HN G 27 G.HN.51
Polar TM2 T 69 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 69 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 69 2x39 G.H5 C 351 G.H5.23
Polar TM3 R 132 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 132 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 132 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM5 L 216 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 216 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 363 6x25 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 L 363 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 M 140 - G.S1 V 34 G.S1.02
Hydrophobic TM2 T 67 2x37 G.H5 D 350 G.H5.22
Polar ICL2 N 143 - G.H5 D 350 G.H5.22
Hydrophobic ICL2 N 143 - G.H5 D 350 G.H5.22
Van-der-waals ICL2 N 143 - G.H5 D 350 G.H5.22
Hydrophobic TM5 R 219 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 219 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM4 Y 146 4x36 G.HN R 24 G.HN.48
Polar TM6 Y 378 6x40 G.H5 G 352 G.H5.24
Polar ICL2 Y 142 - G.H5 D 350 G.H5.22
Hydrophobic ICL2 Y 142 - G.H5 D 350 G.H5.22
Van-der-waals ICL2 Y 142 - G.H5 D 350 G.H5.22
Hydrophobic ICL2 P 139 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 139 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 M 140 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 M 140 - G.S3 L 194 G.S3.01
Polar TM6 K 370 6x32 G.H5 F 354 G.H5.26
Aromatic TM6 K 370 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 370 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 370 6x32 G.H5 F 354 G.H5.26
Polar TM3 A 135 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 135 3x53 G.H5 N 347 G.H5.19
Ionic TM5 R 219 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 219 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 219 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM6 Y 378 6x40 G.H5 L 353 G.H5.25
Hydrophobic TM6 K 367 6x29 G.H5 L 348 G.H5.20
Van-der-waals TM6 K 367 6x29 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 363 6x25 G.H5 F 354 G.H5.26
Hydrophobic TM6 L 375 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL2 M 140 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 M 140 - G.H5 I 343 G.H5.15
Van-der-waals TM6 L 374 6x36 G.H5 G 352 G.H5.24
Hydrophobic ICL2 P 139 - G.H5 I 344 G.H5.16
Hydrophobic ICL2 Y 142 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 Y 142 - G.H5 N 347 G.H5.19
Hydrophobic TM6 K 367 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 K 367 6x29 G.H5 K 345 G.H5.17