Structure information

D2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6VMS

SPECIES

Homo sapiens

RESOLUTION

3.800

PREFERRED CHAIN

R

PUBLICATION DATE

June 17, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
bromocriptine F110 3.28x28 TM3 hydrophobic
bromocriptine D114 3.32x32 TM3 polar (charge-charge)
bromocriptine V115 3.33x33 TM3 hydrophobic
bromocriptine C118 3.36x36 TM3 hydrophobic
bromocriptine T119 3.37x37 TM3 polar (hydrogen bond with backbone)
bromocriptine I183 45.51x51 ECL2 hydrophobic
bromocriptine F389 6.51x51 TM6 hydrophobic
bromocriptine F390 6.52x52 TM6 aromatic (edge-to-face)
bromocriptine Y408 7.35x34 TM7 hydrophobic
bromocriptine T412 7.39x38 TM7 polar (hydrogen bond)

Ligands

bromocriptine

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Residue Diagrams

V N G F V I V A I L L T L L T A Y Y N Y 1 V S L A V A D L L V A L T V M P W V V Y L 2 A C L N L I S A T C M M V D L T V F I D 3 V T V M I S I V W V L S F T I S C P L 4 Y V L L T V I F P V Y F S V I S S Y V V F 5 A I V L G V F I I C W L P F F I T H I L 6 I P N V A S N V Y G L W T F A S Y L V 7
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ICL1 K A L Q ICL1ECL1 E W K F ECL1ICL2 P M L Y N ICL2ECL2 L N N A D Q N E C I I A ECL2ICL3 R S S R A F R A H L R A P L K G N C T H P E D M K L C T V I M K S N G S F P V N R R R V E A A R R A Q E L E M E M L S S T S P P E R T R Y S P I P P S H H Q L T L P D P S H H G L H S T P D S P A K P E K N G H A K D H P K I A K I F E I Q T M P N G K T R T S L K T M S R R ICL3ECL3 D C N I ECL3N-term M D P L N L S W Y D D D L E R Q N W S R P F N G S D G K A D N-termC-term C C-term R P H Y N Y Y A T L L T L L I A V I V F G N V L V C M A V S R E T T T N Y L I V S L A V A D L L V A T L V M P W V V Y L E V V G S R I H C D I F V T L D V M M C T A S I L N L C A I S I D R Y T A V A M T R Y S S K R R V T V M I S I V W V L S F T I S C P L L F G N P A F V V Y S S I V S F Y V P F I V T L L V Y I K I Y I V L R R R R K R V N T K K L S Q Q K E K K A T Q M L A I V L G V F I I C W L P F F I T H I L N I H C P P V L Y S A F T W L G Y V N S A V N P I I Y T T F N I E F L K F R K A I L H
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Residue Table


GPCRdb(A)
GPCRdb(A)
D2 receptor
TM3
3x28 3.28x28 F110
3x32 3.32x32 D114
3x33 3.33x33 V115
3x36 3.36x36 C118
3x37 3.37x37 T119
ECL2
45x51 45.51x51 I183
TM6
6x51 6.51x51 F389
6x52 6.52x52 F390
TM7
7x34 7.35x34 Y408
7x38 7.39x38 T412