P2Y1 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9JCL

RESOLUTION

2.8 Å

REFERENCE

PUBLICATION DATE

Sept. 10, 2025

3D VIEW

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LIGAND INTERACTIONS

51 interactions (Click to see)

LIGANDS

ADP - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

ADP, ATP



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic H8 R 333 8x52 G.h4s6 R 346 G.h4s6.12
Hydrophobic TM2 I 86 2x39 G.H5 Y 381 G.H5.23
Hydrophobic ICL3 P 253 - G.h4s6 Y 348 G.h4s6.20
Van-der-waals ICL3 P 253 - G.h4s6 Y 348 G.h4s6.20
Polar TM3 G 152 3x53 G.H5 N 377 G.H5.19
Hydrophobic TM3 G 152 3x53 G.H5 N 377 G.H5.19
Van-der-waals TM3 G 152 3x53 G.H5 N 377 G.H5.19
Hydrophobic TM5 L 244 5x65 G.H5 L 374 G.H5.16
Hydrophobic H8 D 329 8x48 G.H5 V 384 G.H5.26
Van-der-waals H8 D 329 8x48 G.H5 V 384 G.H5.26
Hydrophobic ICL2 L 160 - G.H5 I 373 G.H5.15
Van-der-waals ICL2 L 160 - G.H5 I 373 G.H5.15
Hydrophobic ICL2 L 160 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 160 - G.S1 H 41 G.S1.02
Hydrophobic TM5 L 244 5x65 G.H5 L 378 G.H5.20
Hydrophobic H8 G 328 8x47 G.H5 N 382 G.H5.24
Van-der-waals H8 G 328 8x47 G.H5 N 382 G.H5.24
Hydrophobic TM4 K 164 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 K 164 4x38 G.HN Q 35 G.HN.52
Polar TM2 S 84 2x37 G.H5 E 380 G.H5.22
Hydrophobic TM2 S 84 2x37 G.H5 E 380 G.H5.22
Van-der-waals TM2 S 84 2x37 G.H5 E 380 G.H5.22
Hydrophobic ICL3 P 253 - G.h4s6 G 345 G.h4s6.11
Polar TM6 S 258 6x34 G.H5 L 383 G.H5.25
Hydrophobic TM6 S 258 6x34 G.H5 L 383 G.H5.25
Van-der-waals TM6 S 258 6x34 G.H5 L 383 G.H5.25
Hydrophobic TM6 L 261 6x37 G.H5 L 383 G.H5.25
Polar H8 T 330 8x49 G.H5 R 379 G.H5.21
Hydrophobic H8 T 330 8x49 G.H5 R 379 G.H5.21
Van-der-waals H8 T 330 8x49 G.H5 R 379 G.H5.21
Van-der-waals ICL2 L 160 - G.hns1 R 38 G.hns1.02
Hydrophobic TM2 M 90 2x43 G.H5 N 382 G.H5.24
Van-der-waals TM2 M 90 2x43 G.H5 N 382 G.H5.24
Polar ICL3 D 250 - G.H5 D 371 G.H5.13
Hydrophobic ICL3 D 250 - G.H5 D 371 G.H5.13
Van-der-waals ICL3 D 250 - G.H5 D 371 G.H5.13
Hydrophobic TM2 I 86 2x39 G.H5 E 380 G.H5.22
Hydrophobic TM6 S 258 6x34 G.H5 V 384 G.H5.26
Van-der-waals TM6 S 258 6x34 G.H5 V 384 G.H5.26
Hydrophobic ICL2 L 157 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 157 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 G 161 - G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 L 157 - G.H5 F 366 G.H5.08
Van-der-waals ICL2 L 157 - G.H5 F 366 G.H5.08
Polar TM3 R 149 3x50 G.H5 Y 381 G.H5.23
Hydrophobic TM3 R 149 3x50 G.H5 Y 381 G.H5.23
Van-der-waals TM3 R 149 3x50 G.H5 Y 381 G.H5.23
Hydrophobic TM3 V 153 3x54 G.H5 L 374 G.H5.16
Van-der-waals TM3 V 153 3x54 G.H5 L 374 G.H5.16
Hydrophobic ICL2 L 157 - G.H5 C 369 G.H5.11
Polar H8 F 331 8x50 G.H5 N 382 G.H5.24
Hydrophobic H8 F 331 8x50 G.H5 N 382 G.H5.24
Van-der-waals H8 F 331 8x50 G.H5 N 382 G.H5.24
Polar H8 T 330 8x49 G.H5 N 382 G.H5.24
Hydrophobic H8 T 330 8x49 G.H5 N 382 G.H5.24
Polar TM3 H 148 3x49 G.H5 Y 381 G.H5.23
Hydrophobic TM3 H 148 3x49 G.H5 Y 381 G.H5.23
Polar ICL2 G 161 - G.HN Q 35 G.HN.52
Hydrophobic ICL2 G 161 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 G 161 - G.HN Q 35 G.HN.52
Polar ICL3 P 253 - G.H5 Q 375 G.H5.17
Hydrophobic ICL3 P 253 - G.H5 Q 375 G.H5.17
Van-der-waals ICL3 P 253 - G.H5 Q 375 G.H5.17
Hydrophobic TM6 K 257 6x33 G.H5 V 384 G.H5.26
Van-der-waals TM6 K 257 6x33 G.H5 V 384 G.H5.26
Polar ICL3 N 251 - G.h4s6 Y 348 G.h4s6.20
Hydrophobic ICL3 N 251 - G.h4s6 Y 348 G.h4s6.20
Van-der-waals ICL3 N 251 - G.h4s6 Y 348 G.h4s6.20
Hydrophobic ICL2 L 157 - G.H5 I 373 G.H5.15
Van-der-waals ICL2 L 157 - G.H5 I 373 G.H5.15
Hydrophobic TM5 K 247 5x68 G.H5 L 374 G.H5.16
Hydrophobic TM3 R 149 3x50 G.H5 L 383 G.H5.25
Polar H8 R 333 8x52 G.h4s6 D 344 G.h4s6.10
Polar TM7 Y 324 7x53 G.H5 N 382 G.H5.24
Van-der-waals TM7 Y 324 7x53 G.H5 N 382 G.H5.24
Hydrophobic ICL3 S 252 - G.h4s6 Y 348 G.h4s6.20
Van-der-waals ICL3 S 252 - G.h4s6 Y 348 G.h4s6.20
Hydrophobic ICL3 L 249 - G.H5 L 374 G.H5.16
Hydrophobic TM3 V 153 3x54 G.H5 Y 381 G.H5.23
Van-der-waals TM5 K 247 5x68 G.H5 K 370 G.H5.12
Hydrophobic ICL2 L 157 - G.S3 F 219 G.S3.03
Hydrophobic TM3 V 153 3x54 G.H5 L 378 G.H5.20
Hydrophobic ICL3 S 252 - G.H5 D 371 G.H5.13
Hydrophobic ICL2 P 156 - G.H5 K 370 G.H5.12
Van-der-waals ICL2 P 156 - G.H5 K 370 G.H5.12
Hydrophobic ICL2 P 156 - G.H5 I 373 G.H5.15
Van-der-waals ICL2 P 156 - G.H5 I 373 G.H5.15
Hydrophobic ICL2 L 157 - G.H5 K 370 G.H5.12
Hydrophobic ICL3 S 252 - G.H5 Q 375 G.H5.17
Van-der-waals ICL3 S 252 - G.H5 Q 375 G.H5.17
Hydrophobic TM6 V 262 6x38 G.H5 L 383 G.H5.25
Hydrophobic ICL2 P 156 - G.H5 L 374 G.H5.16
Polar ICL2 L 163 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 L 163 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 L 163 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL3 L 249 - G.H5 Q 375 G.H5.17
Hydrophobic ICL3 L 249 - G.H5 L 378 G.H5.20
Van-der-waals ICL3 L 249 - G.H5 L 378 G.H5.20
Polar ICL3 S 252 - G.S6 Y 350 G.S6.02
Hydrophobic ICL3 S 252 - G.S6 Y 350 G.S6.02
Van-der-waals ICL3 S 252 - G.S6 Y 350 G.S6.02
Polar TM3 G 152 3x53 G.H5 Y 381 G.H5.23
Hydrophobic TM3 G 152 3x53 G.H5 Y 381 G.H5.23
Van-der-waals TM3 G 152 3x53 G.H5 Y 381 G.H5.23
Hydrophobic ICL2 L 157 - G.S3 V 217 G.S3.01