SMO - Gi1

GPCR CLASS (FAMILY)

Class F (Frizzled)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.9 Å

REFERENCE

PUBLICATION DATE

June 12, 2019

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

24,25-Epoxy-cholesterol - Agonist pubchem

ENDOGENOUS LIGANDS

No endogenous ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic ICL2 Y 350 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Y 350 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 T 349 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 T 349 - G.S3 L 194 G.S3.01
Hydrophobic ICL2 T 348 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 T 348 - G.H5 I 344 G.H5.16
Hydrophobic ICL2 L 346 - G.H5 N 347 G.H5.19
Polar ICL2 T 349 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 T 349 - G.S1 V 34 G.S1.02
Van-der-waals ICL2 T 349 - G.S1 V 34 G.S1.02
Hydrophobic ICL2 L 346 - G.H5 I 344 G.H5.16
Hydrophobic TM3 F 343 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 F 343 3x54 G.H5 C 351 G.H5.23
Polar ICL2 T 348 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 T 348 - G.H5 T 340 G.H5.12
Aromatic TM6 K 444 6x25 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 444 6x25 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 444 6x25 G.H5 F 354 G.H5.26
Ionic ICL1 R 261 - G.H5 D 350 G.H5.22
Polar ICL1 R 261 - G.H5 D 350 G.H5.22
Hydrophobic ICL1 R 261 - G.H5 D 350 G.H5.22
Van-der-waals ICL1 R 261 - G.H5 D 350 G.H5.22
Hydrophobic TM2 P 263 2x40 G.H5 C 351 G.H5.23
Hydrophobic ICL2 T 348 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 T 348 - G.H5 I 343 G.H5.15
Polar TM3 W 339 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 W 339 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 W 339 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 W 339 3x50 G.H5 L 353 G.H5.25
Van-der-waals H8 A 540 8x49 G.H5 F 354 G.H5.26
Hydrophobic TM7 W 535 7x55 G.H5 L 353 G.H5.25
Van-der-waals TM7 W 535 7x55 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 448 6x29 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 448 6x29 G.H5 L 353 G.H5.25
Hydrophobic ICL3 L 437 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 L 437 - G.H5 D 337 G.H5.09
Hydrophobic TM6 S 438 6x19 G.H5 D 341 G.H5.13
Van-der-waals TM6 S 438 6x19 G.H5 D 341 G.H5.13
Hydrophobic ICL3 L 437 - G.H5 T 340 G.H5.12
Van-der-waals ICL3 L 437 - G.H5 T 340 G.H5.12
Van-der-waals ICL1 Y 262 - G.H5 D 350 G.H5.22
Hydrophobic ICL3 P 434 - G.H5 F 336 G.H5.08