δ receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.0 Å

REFERENCE

PUBLICATION DATE

March 4, 2026

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

PHYSIOLOGICAL LIGANDS

[Met]enkephalin (Human), dynorphin A (Human), dynorphin A-(1-8) (Human), dynorphin A-(1-13) (Human), β-endorphin (Mouse), endomorphin-1 (Human), β-endorphin (Rat), dynorphin B (Human), β-endorphin (Human), α-neoendorphin (Human), [Leu]enkephalin (Human)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Polar ICL2 V 154 34x51 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 V 154 34x51 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 V 150 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 150 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 153 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 153 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM5 R 239 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 239 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM2 T 84 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 84 2x39 G.H5 D 350 G.H5.22
Hydrophobic H8 E 323 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM3 R 146 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 146 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 A 149 3x53 G.H5 C 351 G.H5.23
Polar H8 E 323 8x48 G.H5 G 352 G.H5.24
Van-der-waals H8 E 323 8x48 G.H5 G 352 G.H5.24
Hydrophobic ICL2 L 157 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 157 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 L 240 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL3 S 247 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 P 153 34x50 G.H5 T 340 G.H5.12
Van-der-waals ICL2 P 153 34x50 G.H5 T 340 G.H5.12
Hydrophobic ICL2 D 158 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 V 154 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 V 154 34x51 G.S3 L 194 G.S3.01
Polar H8 N 324 8x49 G.H5 G 352 G.H5.24
Hydrophobic H8 N 324 8x49 G.H5 G 352 G.H5.24
Van-der-waals H8 N 324 8x49 G.H5 G 352 G.H5.24
Polar ICL3 R 244 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 R 244 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 244 - G.H5 D 341 G.H5.13
Polar TM2 T 84 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 84 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM5 M 236 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 M 236 5x61 G.H5 L 353 G.H5.25
Polar TM3 D 145 3x49 G.H5 C 351 G.H5.23
Polar ICL3 S 247 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 S 247 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 S 247 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 V 154 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 L 157 34x54 G.S3 L 194 G.S3.01
Hydrophobic ICL2 L 157 34x54 G.H5 I 343 G.H5.15
Hydrophobic TM6 M 262 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 157 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic TM3 R 146 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 V 154 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM6 I 259 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 I 259 6x33 G.H5 F 354 G.H5.26
Polar TM3 A 149 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 149 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 149 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 L 240 5x65 G.H5 I 344 G.H5.16
Polar ICL2 R 160 34x57 G.H5 C 351 G.H5.23
Hydrophobic ICL2 R 160 34x57 G.H5 C 351 G.H5.23
Van-der-waals ICL2 R 160 34x57 G.H5 C 351 G.H5.23
Polar ICL2 R 160 34x57 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 153 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM6 V 263 6x37 G.H5 L 353 G.H5.25