PDB
9PPX
Resolution
3.0 Å
Released
March 4, 2026
Receptor
δ
Class
A
Species
Homo sapiens
Ligand
naltrexone
Function
Antagonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
naltrexone Q105 2.60x60 TM2 polar (hydrogen bond)
naltrexone D128 3.32x32 TM3 Van der Waals
naltrexone Y129 3.33x33 TM3 polar (hydrogen bond)
naltrexone Y129 3.33x33 TM3 polar (hydrogen bond)
naltrexone M132 3.36x36 TM3 Van der Waals
naltrexone W274 6.48x48 TM6 hydrophobic
naltrexone W274 6.48x48 TM6 Van der Waals
naltrexone I277 6.51x51 TM6 Van der Waals
naltrexone I277 6.51x51 TM6 hydrophobic
naltrexone V281 6.55x55 TM6 hydrophobic
naltrexone V281 6.55x55 TM6 Van der Waals
naltrexone I304 7.39x38 TM7 hydrophobic
naltrexone I304 7.39x38 TM7 Van der Waals
naltrexone Y308 7.43x42 TM7 hydrophobic
naltrexone Y308 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 V T R P R D G A V V C M L Q F P S ECL2ICL3 R L L S G ICL3ECL3 D I D R R ECL3N-term M E P A P S A G A E L Q P P L F A N A S D A Y P S A C P S A G A N A S G P P N-termC-term P C G R P D P S S F S R A R E A T A R E R V T A C T P S D G P G G G A A A C-term G A R S A S S L A L A I A I T A L Y S A V C A V G L L G N V L V M F G I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S A K Y L M E G E L L C K A V L S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H T P A K A K L I N I C I W V L A S G V G V P I M V M A P S W Y W D T V T K I C V F L F A F V V P I L I I T V C Y G L M L L R L R S V S K E K D R S L R R I T R M V L V V V G A F V V C W A P I H I F V I V W T L V D P L V V A A L H L C I A L G Y A N S S L N P V L Y A F L D E N F R Q F K R C L C R K
Helix box plot — Download: PNG | SVG V N G L L G V A C V A S Y L A T I A I A 1 F N L A L A D A L A T S T L P F Q S A K 2 M T L T F I S T F M N Y Y D I S L V A K 3 A K L I N I C I W V L A S G V G V P I M 4 Y C V T I I L I P V V F A F L F V C I K T 5 L V V V G A F V V C W A P I H I F V I V 6 V P N L S S N A Y G L A I C L H L A A 7

GPCRdb(A)
GPCRdb(A)
δ receptor
TM2
2x60 2.60x60 Q105
TM3
3x32 3.32x32 D128
3x33 3.33x33 Y129
3x36 3.36x36 M132
TM6
6x48 6.48x48 W274
6x51 6.51x51 I277
6x55 6.55x55 V281
TM7
7x38 7.39x38 I304
7x42 7.43x42 Y308