CRF2 receptor - G11

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

P

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.7 Å

REFERENCE

PUBLICATION DATE

Nov. 9, 2022

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

Urocortin - Agonist pubchem

PHYSIOLOGICAL LIGANDS

corticotrophin-releasing hormone, urocortin 1, urocortin 3, urocortin 2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
N19N24G.H5GproteinA3x57F7x60GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.H5GPCR segments:TM3TM7

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null2x393x493x503x533x545x686x367x56G.H5.25G.H5.24G.H5.23G.H5.20G.H5.19G.H5.16G.H5.15Res. Pos.CRF2 (7TRY)- (7TRY)---------RYLAIKAFRYLAIKAFTYLNLLNI

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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