5-HT1A receptor - Gz

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9VJG

RESOLUTION

2.7 Å

REFERENCE

PUBLICATION DATE

Nov. 12, 2025

3D VIEW

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LIGAND INTERACTIONS

34 interactions (Click to see)

LIGANDS

CHEMBL26998 - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

5-hydroxytryptamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 A 222 5x65 G.H5 C 355 G.H5.26
Hydrophobic TM5 A 222 5x65 G.H5 L 349 G.H5.20
Van-der-waals TM5 A 222 5x65 G.H5 L 349 G.H5.20
Hydrophobic ICL2 Y 144 34x53 G.H5 I 344 G.H5.15
Polar TM6 T 346 6x36 G.H5 G 353 G.H5.24
Hydrophobic TM6 T 346 6x36 G.H5 G 353 G.H5.24
Van-der-waals TM6 T 346 6x36 G.H5 G 353 G.H5.24
Ionic ICL2 K 147 34x56 G.s2s3 E 194 G.s2s3.02
Hydrophobic TM3 I 138 3x54 G.H5 I 345 G.H5.16
Van-der-waals TM3 I 138 3x54 G.H5 I 345 G.H5.16
Hydrophobic ICL2 V 145 34x54 G.H5 I 344 G.H5.15
Van-der-waals ICL2 V 145 34x54 G.H5 I 344 G.H5.15
Hydrophobic ICL2 I 142 34x51 G.H5 F 337 G.H5.08
Van-der-waals ICL2 I 142 34x51 G.H5 F 337 G.H5.08
Polar ICL2 Y 144 34x53 G.H5 Y 351 G.H5.22
Hydrophobic ICL2 Y 144 34x53 G.H5 Y 351 G.H5.22
Van-der-waals ICL2 Y 144 34x53 G.H5 Y 351 G.H5.22
Hydrophobic TM3 A 137 3x53 G.H5 I 352 G.H5.23
Hydrophobic TM6 L 347 6x37 G.H5 L 354 G.H5.25
Van-der-waals TM6 L 347 6x37 G.H5 L 354 G.H5.25
Van-der-waals H8 N 404 8x47 G.H5 Y 351 G.H5.22
Hydrophobic ICL2 P 141 34x50 G.H5 I 344 G.H5.15
Van-der-waals ICL2 P 141 34x50 G.H5 I 344 G.H5.15
Hydrophobic TM3 I 138 3x54 G.H5 N 348 G.H5.19
Hydrophobic ICL2 N 146 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 N 146 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 V 145 34x54 G.hns1 R 32 G.hns1.03
Ionic TM5 R 225 5x68 G.H5 D 342 G.H5.13
Polar TM5 R 225 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM5 R 225 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 R 225 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM3 I 138 3x54 G.H5 I 352 G.H5.23
Van-der-waals TM3 I 138 3x54 G.H5 I 352 G.H5.23
Hydrophobic ICL2 V 145 34x54 G.S1 I 34 G.S1.02
Hydrophobic TM5 R 225 5x68 G.H5 L 349 G.H5.20
Polar H8 K 405 8x48 G.H5 K 350 G.H5.21
Hydrophobic TM3 I 138 3x54 G.H5 L 354 G.H5.25
Van-der-waals TM3 I 138 3x54 G.H5 L 354 G.H5.25
Hydrophobic ICL2 V 145 34x54 G.S3 L 195 G.S3.01
Hydrophobic TM6 M 335 6x25 G.h4s6 E 316 G.h4s6.09
Van-der-waals TM6 M 335 6x25 G.h4s6 E 316 G.h4s6.09
Polar TM3 A 137 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 137 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 137 3x53 G.H5 N 348 G.H5.19
Polar ICL2 Y 144 34x53 G.H5 N 348 G.H5.19
Hydrophobic ICL2 Y 144 34x53 G.H5 N 348 G.H5.19
Van-der-waals ICL2 Y 144 34x53 G.H5 N 348 G.H5.19
Hydrophobic TM5 R 225 5x68 G.H5 Q 346 G.H5.17
Van-der-waals TM5 R 225 5x68 G.H5 Q 346 G.H5.17
Hydrophobic TM5 I 226 5x69 G.H5 C 355 G.H5.26
Van-der-waals TM5 I 226 5x69 G.H5 C 355 G.H5.26
Hydrophobic TM6 M 335 6x25 G.h4s6 K 315 G.h4s6.08
Polar TM6 T 343 6x33 G.H5 C 355 G.H5.26
Van-der-waals TM6 T 343 6x33 G.H5 C 355 G.H5.26
Hydrophobic ICL2 P 141 34x50 G.H5 T 341 G.H5.12
Van-der-waals ICL2 P 141 34x50 G.H5 T 341 G.H5.12
Hydrophobic TM3 I 138 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 I 138 3x54 G.H5 L 349 G.H5.20
Hydrophobic TM6 K 342 6x32 G.H5 L 354 G.H5.25
Van-der-waals TM6 K 342 6x32 G.H5 L 354 G.H5.25
Hydrophobic TM6 R 339 6x29 G.H5 C 355 G.H5.26
Hydrophobic ICL2 I 142 34x51 G.s2s3 E 194 G.s2s3.02
Polar ICL2 V 145 34x54 G.hns1 R 31 G.hns1.02
Hydrophobic TM3 R 134 3x50 G.H5 I 352 G.H5.23
Van-der-waals TM3 R 134 3x50 G.H5 I 352 G.H5.23
Polar ICL2 N 146 34x55 G.s2s3 E 194 G.s2s3.02
Van-der-waals ICL2 N 146 34x55 G.s2s3 E 194 G.s2s3.02
Polar TM6 R 339 6x29 G.h4s6 E 316 G.h4s6.09
Polar TM6 T 343 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 T 343 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 T 343 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM5 R 225 5x68 G.H5 I 345 G.H5.16
Van-der-waals TM5 R 225 5x68 G.H5 I 345 G.H5.16
Polar TM6 K 342 6x32 G.H5 G 353 G.H5.24
Hydrophobic TM6 K 342 6x32 G.H5 G 353 G.H5.24
Van-der-waals TM6 K 342 6x32 G.H5 G 353 G.H5.24
Hydrophobic TM5 A 222 5x65 G.H5 L 354 G.H5.25
Hydrophobic TM5 T 229 5x72 G.H5 Q 346 G.H5.17
Polar TM6 K 342 6x32 G.H5 C 355 G.H5.26
Hydrophobic TM6 K 342 6x32 G.H5 C 355 G.H5.26
Van-der-waals ICL2 I 142 34x51 G.s2s3 K 193 G.s2s3.01
Hydrophobic ICL2 P 141 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 141 34x50 G.H5 I 345 G.H5.16
Hydrophobic TM5 I 218 5x61 G.H5 L 354 G.H5.25
Van-der-waals TM5 I 218 5x61 G.H5 L 354 G.H5.25
Hydrophobic TM5 T 229 5x72 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 T 346 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 T 346 6x36 G.H5 L 354 G.H5.25
Hydrophobic TM2 A 71 2x39 G.H5 Y 351 G.H5.22