GPR4 - G13

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

G12/13

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.4 Å

REFERENCE

PUBLICATION DATE

April 23, 2025

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

Apo (no ligand) -

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Hydrophobic ICL2 P 122 - G.H5 N 223 G.H5.19
Van-der-waals ICL2 P 122 - G.H5 N 223 G.H5.19
Polar H8 G 292 8x49 G.H5 Q 230 G.H5.26
Hydrophobic H8 G 292 8x49 G.H5 Q 230 G.H5.26
Van-der-waals H8 G 292 8x49 G.H5 Q 230 G.H5.26
Polar ICL2 A 120 - G.H5 K 216 G.H5.12
Hydrophobic TM5 I 204 5x61 G.H5 M 228 G.H5.24
Van-der-waals TM5 I 204 5x61 G.H5 M 228 G.H5.24
Polar ICL3 V 212 - G.H5 D 217 G.H5.13
Hydrophobic ICL1 N 50 - G.H5 L 227 G.H5.23
Hydrophobic ICL2 P 122 - G.H5 I 219 G.H5.15
Van-der-waals ICL2 P 122 - G.H5 I 219 G.H5.15
Polar ICL3 S 213 - G.H5 H 221 G.H5.17
Hydrophobic ICL3 S 213 - G.H5 H 221 G.H5.17
Van-der-waals ICL3 S 213 - G.H5 H 221 G.H5.17
Hydrophobic TM6 E 218 6x29 G.H5 L 229 G.H5.25
Van-der-waals TM6 E 218 6x29 G.H5 L 229 G.H5.25
Hydrophobic ICL3 S 213 - G.h4s6 P 194 G.h4s6.20
Van-der-waals ICL3 S 213 - G.h4s6 P 194 G.h4s6.20
Hydrophobic TM5 V 208 5x65 G.H5 L 224 G.H5.20
Hydrophobic TM3 A 118 3x53 G.H5 L 227 G.H5.23
Hydrophobic TM6 E 218 6x29 G.H5 K 225 G.H5.21
Hydrophobic ICL3 S 211 - G.H5 L 220 G.H5.16
Hydrophobic ICL2 A 126 - G.hns1 R 32 G.hns1.03
Polar ICL1 N 50 - G.H5 Q 226 G.H5.22
Van-der-waals ICL1 N 50 - G.H5 Q 226 G.H5.22
Hydrophobic TM3 V 119 3x54 G.H5 M 228 G.H5.24
Polar H8 E 291 8x48 G.H5 L 229 G.H5.25
Hydrophobic TM6 I 222 6x33 G.H5 L 229 G.H5.25
Polar H8 N 290 8x47 G.H5 Q 230 G.H5.26
Hydrophobic H8 N 290 8x47 G.H5 Q 230 G.H5.26
Van-der-waals H8 N 290 8x47 G.H5 Q 230 G.H5.26
Polar H8 E 291 8x48 G.H5 Q 230 G.H5.26
Hydrophobic H8 E 291 8x48 G.H5 Q 230 G.H5.26
Van-der-waals H8 E 291 8x48 G.H5 Q 230 G.H5.26
Hydrophobic H8 N 290 8x47 G.H5 L 229 G.H5.25
Hydrophobic TM3 R 115 3x50 G.H5 M 228 G.H5.24
Hydrophobic TM3 V 119 3x54 G.H5 L 224 G.H5.20
Van-der-waals TM3 V 119 3x54 G.H5 L 224 G.H5.20
Hydrophobic TM6 I 222 6x33 G.H5 L 224 G.H5.20
Polar TM6 K 221 6x32 G.H5 L 229 G.H5.25
Hydrophobic TM6 K 221 6x32 G.H5 L 229 G.H5.25
Van-der-waals TM6 K 221 6x32 G.H5 L 229 G.H5.25
Hydrophobic ICL3 V 212 - G.S6 Y 196 G.S6.02
Hydrophobic ICL2 L 123 - G.H5 F 212 G.H5.08
Hydrophobic TM6 I 222 6x33 G.H5 M 228 G.H5.24
Van-der-waals H8 N 290 8x47 G.H5 M 228 G.H5.24
Polar TM3 A 118 3x53 G.H5 N 223 G.H5.19
Hydrophobic TM3 A 118 3x53 G.H5 N 223 G.H5.19
Van-der-waals TM3 A 118 3x53 G.H5 N 223 G.H5.19
Hydrophobic ICL3 T 214 - G.H5 H 221 G.H5.17
Hydrophobic TM6 L 225 6x36 G.H5 M 228 G.H5.24
Hydrophobic ICL2 P 122 - G.H5 K 216 G.H5.12
Hydrophobic TM3 V 119 3x54 G.H5 L 220 G.H5.16
Van-der-waals TM3 V 119 3x54 G.H5 L 220 G.H5.16
Hydrophobic ICL2 L 123 - G.H5 I 219 G.H5.15
Van-der-waals ICL2 L 123 - G.H5 I 219 G.H5.15