Refined structure (8GHV) of Gi1 - CB1 receptor

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

3D VIEW

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Structure
GPCR

Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 218 from structure (61.6%), 136 from model (38.4%)
Residue sidechains - 191 from structure (54.0%), 163 from model (46.0%)

REFINED GPCR RESIDUES

Residue backbones - 280 from structure (67.0%), 138 from model (33.0%)
Residue sidechains - 251 from structure (60.0%), 167 from model (40.0%)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
E12G.h4s6N19D22C23F26G.H5GproteinS2x39S3x53K8x48Q6x26R3x50GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.h4s6G.H5GPCR segments:TM2TM3TM6H8

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null2x393x503x533x5434x5034x5134x5334x5434x555x685x725x756x266x286x296x326x336x377x568x48G.H5.26G.H5.25G.H5.23G.H5.22G.H5.20G.H5.19G.H5.17G.H5.16G.H5.15G.H5.13G.H5.09G.h4s6.12G.H4.16G.S3.01G.hns1.03Res. Pos.CB1 (8GHV_REFINED)- (8GHV_REFINED)---------------------SRSIPLYKRHMRQRMRLLRKSPLYKRRSIHMRQRMRLLRKRDIINLRCLLDDEKFE

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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