NTS1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Rattus norvegicus

GPCR PREFERRED CHAIN

C

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

4.1 Å

REFERENCE

PUBLICATION DATE

Jan. 6, 2021

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

neurotensin - Agonist pubchem gtoplig chembl_ligand gtoplig gtoplig

ENDOGENOUS LIGANDS

neurotensin, neuromedin N



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Aromatic ICL2 F 175 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 F 175 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 F 175 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM6 L 310 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 310 6x37 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 174 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 174 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM5 M 267 5x68 G.H5 K 345 G.H5.17
Hydrophobic TM5 I 260 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM2 V 102 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 V 102 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM6 L 303 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 L 303 6x30 G.H5 F 354 G.H5.26
Hydrophobic TM6 V 309 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 T 179 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 G 306 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 K 178 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 K 178 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 I 171 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 171 3x54 G.H5 L 348 G.H5.20
Polar ICL2 K 178 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 K 178 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic TM6 L 303 6x30 G.H5 L 348 G.H5.20
Hydrophobic TM3 A 170 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 170 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 167 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 167 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 171 3x54 G.H5 I 344 G.H5.16
Polar TM4 S 182 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 S 182 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 S 182 4x38 G.HN E 28 G.HN.52
Ionic TM4 R 185 4x41 G.HN E 28 G.HN.52
Polar TM4 R 185 4x41 G.HN E 28 G.HN.52
Hydrophobic TM4 R 185 4x41 G.HN E 28 G.HN.52
Van-der-waals TM4 R 185 4x41 G.HN E 28 G.HN.52
Hydrophobic TM2 V 102 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 V 102 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL2 K 178 34x54 G.S1 V 34 G.S1.02
Hydrophobic ICL2 F 175 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 F 175 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL3 I 295 - G.h4s6 K 314 G.h4s6.08
Polar TM4 S 184 4x40 G.HN E 28 G.HN.52
Hydrophobic TM5 L 264 5x65 G.H5 L 353 G.H5.25
Hydrophobic ICL2 F 175 34x51 G.H5 I 343 G.H5.15
Hydrophobic ICL2 K 178 34x54 G.H5 I 343 G.H5.15
Hydrophobic TM5 M 267 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 M 267 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM6 R 299 6x26 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 R 299 6x26 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 A 302 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 302 6x29 G.H5 F 354 G.H5.26
Van-der-waals ICL1 Q 99 - G.H5 D 350 G.H5.22
Hydrophobic ICL2 F 175 34x51 G.H5 V 339 G.H5.11
Van-der-waals ICL2 F 175 34x51 G.H5 V 339 G.H5.11
Hydrophobic ICL2 F 175 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 F 175 34x51 G.H5 T 340 G.H5.12
Polar TM3 A 170 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 170 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 170 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 I 171 3x54 G.H5 N 347 G.H5.19
Van-der-waals TM3 I 171 3x54 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 174 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 174 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM5 L 264 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 264 5x65 G.H5 L 348 G.H5.20
Van-der-waals ICL1 Q 99 - G.hns1 A 31 G.hns1.02
Polar TM3 E 166 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 E 166 3x49 G.H5 C 351 G.H5.23
Van-der-waals TM3 E 166 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM6 G 306 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 G 306 6x33 G.H5 F 354 G.H5.26
Polar TM3 R 167 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 167 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 167 3x50 G.H5 C 351 G.H5.23