5-HT1A receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.1 Å

REFERENCE

PUBLICATION DATE

April 14, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

aripiprazole - Agonist (partial) pubchem gtoplig chembl_ligand drugbank drug_central

PHYSIOLOGICAL LIGANDS

5-hydroxytryptamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
D02G.s2s3D17G.H4D09G.h4s6D13N19G24F26G.H5GproteinR5x68T6x36T6x33Y34x53N34x55N6x18R6x29GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.s2s3G.H4G.h4s6G.H5GPCR segments:ICL2TM5TM6

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
3x503x533x5434x5034x5134x5334x5434x5534x565x615x655x685x696x186x256x296x326x336x366x37G.H5.26G.H5.25G.H5.24G.H5.23G.H5.20G.H5.19G.H5.16G.H5.15G.H5.13G.H5.12G.H5.08G.h4s6.09G.H4.17G.S3.01G.s2s3.02G.S1.02G.hns1.03Res. Pos.5-HT1A (7E2Z)- (7E2Z)--------------------RAIPIYVNKIARINMRKTTLPIYVNKRAIIARINMRKTTLTIIFNVLRDCLLDFDDG

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.