Structure information

5-HT1A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7E2Z

SPECIES

Homo sapiens

RESOLUTION

3.100

PREFERRED CHAIN

R

REFERENCE

10.1038/S41586-021-03376-8

PUBLICATION DATE

April 14, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
aripiprazole Y96 2.64x63 TM2 aromatic (edge-to-face)
aripiprazole F112 3.28x28 TM3 hydrophobic
aripiprazole D116 3.32x32 TM3 polar (charge-assisted hydrogen bond)
aripiprazole V117 3.33x33 TM3 Van der Waals
aripiprazole V117 3.33x33 TM3 hydrophobic
aripiprazole C120 3.36x36 TM3 Van der Waals
aripiprazole I189 45.52x52 ECL2 Van der Waals
aripiprazole I189 45.52x52 ECL2 hydrophobic
aripiprazole S199 5.42x43 TM5 Van der Waals
aripiprazole T200 5.43x44 TM5 Van der Waals
aripiprazole A203 5.46x461 TM5 Van der Waals
aripiprazole W358 6.48x48 TM6 hydrophobic
aripiprazole F361 6.51x51 TM6 hydrophobic
aripiprazole F361 6.51x51 TM6 Van der Waals
aripiprazole F362 6.52x52 TM6 aromatic (edge-to-face)
aripiprazole F362 6.52x52 TM6 Van der Waals
aripiprazole Y390 7.43x42 TM7 Van der Waals
aripiprazole Y390 7.43x42 TM7 hydrophobic

Ligands

aripiprazole

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Residue Diagrams

A N G L V A C F I L T G L L L S T I V Q 1 G S L A V T D L M V S L V V L P M A A L Y 2 A C L H L I S S T C C L V D L A I F L D 3 A A A L I S L T W L I G F L I S I P P M 4 Y L V L M L L L P I Y F A G F T S Y I T Y 5 G I I M G T F I L C W L P F F I V A L V 6 V P N L L S N S Y G L W N I I A G L L 7
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ICL1 R S L Q ICL1ECL1 K W T L ECL1ICL2 P I D Y V N K R ICL2ECL2 R T P E D R S D P D A C T I S K ECL2ICL3 E K T G A D T R H G A S P A P Q P K K S V N G E S G S R N W R L G V E S K A G G A L C A N G A V R Q G D D G A A L E V I E V H R V G N S K E H L P L P S E A G P T P C A P A S F E R ICL3ECL3 E S S C H M ECL3N-term M D V L S P G Q G N N T T S P P A P F E T G G N T T G I S D V N-termC-term K C K F C R Q C-term T V S Y Q V I T S L L L G T L I F C A V L G N A C V V A A I A L E N V A N Y L I G S L A V T D L M V S V L V L P M A A L Y Q V L N G Q V T C D L F I A L D V L C C T S S I L H L C A I A L D R Y W A I T D T P R R A A A L I S L T W L I G F L I S I P P M L G W D H G Y T I Y S T F G A F Y I P L L L M L V L Y G R I F R A A R F R I R K T V K K V K N E R N A E A K R K M A L A R E R K T V K T L G I I M G T F I L C W L P F F I V A L V L P F C P T L L G A I I N W L G Y S N S L L N P V I Y A Y F N K D F K K F Q N A I I
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT1A receptor
TM2
2x63 2.64x63 Y96
TM3
3x28 3.28x28 F112
3x32 3.32x32 D116
3x33 3.33x33 V117
3x36 3.36x36 C120
ECL2
45x52 45.52x52 I189
TM5
5x43 5.42x43 S199
5x44 5.43x44 T200
5x461 5.46x461 A203
TM6
6x48 6.48x48 W358
6x51 6.51x51 F361
6x52 6.52x52 F362
TM7
7x42 7.43x42 Y390