mGlu2 receptor - Gi1

GPCR CLASS (FAMILY)

Class C (Glutamate)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7E9G

RESOLUTION

3.5 Å

REFERENCE

10.1038/S41586-021-03495-2

PUBLICATION DATE

June 23, 2021

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

34 interactions (Click to see)

LIGANDS

JNJ-40411813 - PAM pubchem gtoplig chembl_ligand drugbank ,

eglumegad - Agonist pubchem gtoplig chembl_ligand gtoplig

PHYSIOLOGICAL LIGANDS

L-glutamic acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 Q 669 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 Q 669 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 Q 669 - G.hns1 A 31 G.hns1.02
Hydrophobic TM3 R 659 3x56 G.H5 N 347 G.H5.19
Van-der-waals TM3 R 659 3x56 G.H5 N 347 G.H5.19
Hydrophobic ICL2 E 666 - G.S3 L 194 G.S3.01
Hydrophobic ICL2 P 671 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 G 667 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 G 667 - G.S3 L 194 G.S3.01
Ionic ICL2 R 665 - G.s2s3 D 193 G.s2s3.02
Polar ICL2 R 665 - G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 R 665 - G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 R 665 - G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 G 667 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 G 667 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 A 664 - G.H5 I 344 G.H5.16
Hydrophobic ICL2 A 668 - G.h2s4 T 219 G.h2s4.05
Hydrophobic TM3 R 659 3x56 G.H5 L 348 G.H5.20
Van-der-waals ICL2 R 670 - G.H5 N 347 G.H5.19
Hydrophobic TM3 I 660 3x57 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 660 3x57 G.H5 L 348 G.H5.20
Hydrophobic TM3 R 656 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 656 3x53 G.H5 C 351 G.H5.23
Ionic ICL2 R 670 - G.H5 D 350 G.H5.22
Polar ICL2 R 670 - G.H5 D 350 G.H5.22
Hydrophobic ICL2 R 670 - G.H5 D 350 G.H5.22
Van-der-waals ICL2 R 670 - G.H5 D 350 G.H5.22
Polar ICL2 A 668 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 A 668 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 A 668 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL1 K 599 12x51 G.H5 G 352 G.H5.24
Hydrophobic ICL2 A 664 - G.H5 I 343 G.H5.15
Polar ICL2 Q 669 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 Q 669 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 669 - G.hns1 R 32 G.hns1.03
Hydrophobic TM4 P 676 4x29 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 656 3x53 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 656 3x53 G.H5 L 353 G.H5.25
Hydrophobic TM6 F 756 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM3 I 660 3x57 G.H5 I 344 G.H5.16
Van-der-waals TM3 I 660 3x57 G.H5 I 344 G.H5.16
Hydrophobic ICL1 K 599 12x51 G.H5 L 353 G.H5.25
Van-der-waals ICL1 K 599 12x51 G.H5 L 353 G.H5.25
Hydrophobic ICL2 A 668 - G.S1 V 34 G.S1.02
Polar ICL1 A 600 12x52 G.H5 L 353 G.H5.25
Hydrophobic ICL1 A 600 12x52 G.H5 L 353 G.H5.25
Van-der-waals ICL1 A 600 12x52 G.H5 L 353 G.H5.25
Ionic ICL2 E 666 - G.hns1 R 32 G.hns1.03
Polar ICL2 E 666 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 E 666 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 E 666 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 I 674 - G.H5 C 351 G.H5.23
Van-der-waals ICL2 I 674 - G.H5 C 351 G.H5.23
Hydrophobic ICL2 A 664 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 A 664 - G.H5 T 340 G.H5.12
Hydrophobic ICL2 A 668 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 A 668 - G.H5 I 343 G.H5.15