GPR21 - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8HMV

RESOLUTION

2.9 Å

REFERENCE

10.1002/MCO2.205

PUBLICATION DATE

March 1, 2023

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) - Apo (no ligand)

ENDOGENOUS LIGANDS

No endogenous ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

GPCR AA GPCR number GPCRdb# Segment G protein AA G protein number CGN# Interaction Type
H 221 5x69 TM5 L 388 G.H5.20 hydrophobic
H 221 5x69 TM5 L 388 G.H5.20 van-der-waals
P 134 - ICL2 R 380 G.H5.12 hydrophobic
P 134 - ICL2 I 383 G.H5.15 hydrophobic
P 134 - ICL2 I 383 G.H5.15 van-der-waals
Y 137 - ICL2 H 387 G.H5.19 hydrophobic
R 228 5x76 TM5 T 350 G.h4s6.03 hydrophobic
F 232 5x80 TM5 D 343 G.H4.13 hydrophobic
A 130 3x53 TM3 Y 391 G.H5.23 hydrophobic
A 130 3x53 TM3 Y 391 G.H5.23 van-der-waals
L 135 - ICL2 R 380 G.H5.12 hydrophobic
N 138 - ICL2 R 38 G.hns1.02 hydrophobic
I 217 5x65 TM5 L 388 G.H5.20 hydrophobic
T 142 4x38 TM4 Q 35 G.HN.52 hydrophobic
R 231 5x79 TM5 D 323 G.hgh4.13 ionic
R 231 5x79 TM5 D 323 G.hgh4.13 polar
R 231 5x79 TM5 D 323 G.hgh4.13 hydrophobic
R 231 5x79 TM5 D 323 G.hgh4.13 van-der-waals
H 221 5x69 TM5 R 385 G.H5.17 aromatic
H 221 5x69 TM5 R 385 G.H5.17 hydrophobic
I 131 3x54 TM3 L 393 G.H5.25 hydrophobic
I 131 3x54 TM3 Y 391 G.H5.23 hydrophobic
A 130 3x53 TM3 H 387 G.H5.19 polar
A 130 3x53 TM3 H 387 G.H5.19 van-der-waals
I 131 3x54 TM3 L 388 G.H5.20 hydrophobic
I 131 3x54 TM3 L 388 G.H5.20 van-der-waals
L 135 - ICL2 C 379 G.H5.11 hydrophobic
I 214 5x62 TM5 L 388 G.H5.20 hydrophobic
F 232 5x80 TM5 L 346 G.H4.16 hydrophobic
F 232 5x80 TM5 L 346 G.H4.16 van-der-waals
C 218 5x66 TM5 L 393 G.H5.25 polar
C 218 5x66 TM5 L 393 G.H5.25 hydrophobic
C 218 5x66 TM5 L 393 G.H5.25 van-der-waals
R 228 5x76 TM5 C 359 G.S6.01 polar
R 228 5x76 TM5 C 359 G.S6.01 van-der-waals
V 253 6x36 TM6 L 393 G.H5.25 hydrophobic
V 253 6x36 TM6 L 393 G.H5.25 van-der-waals
H 62 - ICL1 Q 390 G.H5.22 polar
R 231 5x79 TM5 P 321 G.hgh4.11 van-der-waals
N 308 8x47 H8 E 392 G.H5.24 polar
I 225 5x73 TM5 R 385 G.H5.17 hydrophobic
I 225 5x73 TM5 R 385 G.H5.17 van-der-waals
L 135 - ICL2 V 217 G.S3.01 hydrophobic
R 249 6x32 TM6 E 392 G.H5.24 ionic
R 249 6x32 TM6 E 392 G.H5.24 polar
R 249 6x32 TM6 E 392 G.H5.24 hydrophobic
T 136 - ICL2 V 217 G.S3.01 hydrophobic
I 131 3x54 TM3 H 387 G.H5.19 hydrophobic
P 134 - ICL2 H 387 G.H5.19 hydrophobic
R 228 5x76 TM5 L 346 G.H4.16 hydrophobic
R 228 5x76 TM5 L 346 G.H4.16 van-der-waals
F 232 5x80 TM5 R 347 G.H4.17 hydrophobic
H 221 5x69 TM5 D 381 G.H5.13 ionic
H 221 5x69 TM5 D 381 G.H5.13 polar
H 221 5x69 TM5 D 381 G.H5.13 van-der-waals
L 135 - ICL2 H 41 G.S1.02 polar
L 135 - ICL2 H 41 G.S1.02 hydrophobic
V 253 6x36 TM6 E 392 G.H5.24 hydrophobic
V 253 6x36 TM6 E 392 G.H5.24 van-der-waals
Y 250 6x33 TM6 L 393 G.H5.25 hydrophobic
Y 250 6x33 TM6 L 393 G.H5.25 van-der-waals
T 132 3x55 TM3 R 380 G.H5.12 polar
T 132 3x55 TM3 R 380 G.H5.12 van-der-waals
P 134 - ICL2 Q 384 G.H5.16 hydrophobic
Q 229 5x77 TM5 T 350 G.h4s6.03 hydrophobic
D 224 5x72 TM5 Y 358 G.h4s6.20 polar
F 232 5x80 TM5 T 350 G.h4s6.03 hydrophobic
R 127 3x50 TM3 Y 391 G.H5.23 aromatic
R 127 3x50 TM3 Y 391 G.H5.23 hydrophobic
I 214 5x62 TM5 L 393 G.H5.25 hydrophobic
C 218 5x66 TM5 L 388 G.H5.20 hydrophobic
C 218 5x66 TM5 L 388 G.H5.20 van-der-waals
R 249 6x32 TM6 L 394 G.H5.26 polar
R 249 6x32 TM6 L 394 G.H5.26 hydrophobic
R 249 6x32 TM6 L 394 G.H5.26 van-der-waals
S 309 8x48 H8 E 392 G.H5.24 polar
L 135 - ICL2 I 383 G.H5.15 hydrophobic
L 135 - ICL2 I 383 G.H5.15 van-der-waals
I 131 3x54 TM3 Q 384 G.H5.16 polar
I 131 3x54 TM3 Q 384 G.H5.16 van-der-waals
I 217 5x65 TM5 Q 384 G.H5.16 hydrophobic
L 135 - ICL2 F 376 G.H5.08 hydrophobic
L 135 - ICL2 F 376 G.H5.08 van-der-waals
H 221 5x69 TM5 Q 384 G.H5.16 polar
H 221 5x69 TM5 Q 384 G.H5.16 hydrophobic
H 221 5x69 TM5 Q 384 G.H5.16 van-der-waals
L 254 6x37 TM6 L 393 G.H5.25 hydrophobic
L 254 6x37 TM6 L 393 G.H5.25 van-der-waals
R 228 5x76 TM5 Y 358 G.h4s6.20 polar
R 228 5x76 TM5 Y 358 G.h4s6.20 aromatic
R 228 5x76 TM5 Y 358 G.h4s6.20 hydrophobic
R 228 5x76 TM5 Y 358 G.h4s6.20 van-der-waals