δ receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

March 4, 2026

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

SNC80 - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

[Met]enkephalin (Human), dynorphin A (Human), dynorphin A-(1-8) (Human), dynorphin A-(1-13) (Human), β-endorphin (Mouse), endomorphin-1 (Human), β-endorphin (Rat), dynorphin B (Human), β-endorphin (Human), α-neoendorphin (Human), [Leu]enkephalin (Human)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Hydrophobic TM3 V 150 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 153 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 153 - G.H5 I 343 G.H5.15
Hydrophobic TM5 R 239 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM6 S 255 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM2 T 84 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 84 2x39 G.H5 D 350 G.H5.22
Ionic ICL3 R 244 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 R 244 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 R 244 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 244 - G.h4s6 E 318 G.h4s6.12
Hydrophobic H8 E 323 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 E 323 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 E 323 8x48 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 146 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 A 149 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 149 3x53 G.H5 C 351 G.H5.23
Polar H8 E 323 8x48 G.H5 G 352 G.H5.24
Hydrophobic H8 E 323 8x48 G.H5 G 352 G.H5.24
Van-der-waals H8 E 323 8x48 G.H5 G 352 G.H5.24
Hydrophobic TM5 L 240 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 240 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM5 M 236 5x61 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 153 - G.H5 T 340 G.H5.12
Polar H8 N 324 8x49 G.H5 K 349 G.H5.21
Hydrophobic H8 D 322 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 D 322 8x47 G.H5 G 352 G.H5.24
Polar H8 N 324 8x49 G.H5 G 352 G.H5.24
Hydrophobic H8 N 324 8x49 G.H5 G 352 G.H5.24
Polar TM2 T 84 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 T 84 2x39 G.H5 C 351 G.H5.23
Polar ICL3 R 244 - G.S6 I 319 G.S6.01
Hydrophobic TM5 M 236 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 M 236 5x61 G.H5 L 353 G.H5.25
Polar TM3 D 145 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM6 I 259 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 259 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 157 - G.S3 L 194 G.S3.01
Polar H8 N 324 8x49 G.H5 D 350 G.H5.22
Hydrophobic TM6 M 262 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 146 3x50 G.H5 C 351 G.H5.23
Polar TM3 A 149 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 149 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 149 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 L 240 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM5 V 243 5x68 G.H5 I 344 G.H5.16
Polar ICL2 R 160 - G.H5 C 351 G.H5.23
Hydrophobic ICL2 R 160 - G.H5 C 351 G.H5.23
Van-der-waals ICL2 R 160 - G.H5 C 351 G.H5.23
Hydrophobic ICL3 L 246 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 L 246 - G.H5 F 354 G.H5.26
Hydrophobic ICL3 L 246 - G.H5 L 348 G.H5.20
Hydrophobic ICL3 L 245 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 L 245 - G.H5 K 345 G.H5.17
Hydrophobic ICL2 P 153 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 153 - G.H5 I 344 G.H5.16
Hydrophobic ICL3 L 245 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 E 251 6x25 G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL3 R 244 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 R 244 - G.S6 Y 320 G.S6.02