Refined structure (7YK7) of Gi2 - RXFP4

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 218 from structure (61.4%), 137 from model (38.6%)
Residue sidechains - 212 from structure (59.7%), 143 from model (40.3%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 AF2 AF2
G.HN 5 V G.HN.11 Structure Structure
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure Structure
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure Structure
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 A G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure Structure
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure Structure
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 K G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure Structure
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure Structure
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure Structure
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure Structure
G.s1h1 44 S G.s1h1.05 Structure Structure
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure Structure
G.H1 47 S G.H1.02 Structure AF2
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure Structure
G.H1 52 Q G.H1.07 Structure Structure
G.H1 53 M G.H1.08 Structure Structure
G.H1 54 K G.H1.09 AF2 AF2
G.H1 55 I G.H1.10 AF2 AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 D G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 R H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 R H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 M H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 V H.HA.23 AF2 AF2
H.HA 86 K H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 N H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 Q H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 A H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 P H.hahb.09 AF2 AF2
H.HB 99 S H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 A H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 S H.HB.13 AF2 AF2
H.HB 112 C H.HB.14 AF2 AF2
H.hbhc 113 T H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 Q H.hbhc.11 AF2 AF2
H.hbhc 118 G H.hbhc.12 AF2 AF2
H.hbhc 119 V H.hbhc.13 AF2 AF2
H.hbhc 120 L H.hbhc.14 AF2 AF2
H.hbhc 121 P H.hbhc.15 AF2 AF2
H.HC 122 D H.HC.01 AF2 AF2
H.HC 123 D H.HC.02 AF2 AF2
H.HC 124 L H.HC.03 AF2 AF2
H.HC 125 S H.HC.04 AF2 AF2
H.HC 126 G H.HC.05 AF2 AF2
H.HC 127 V H.HC.06 AF2 AF2
H.HC 128 I H.HC.07 AF2 AF2
H.HC 129 R H.HC.08 AF2 AF2
H.HC 130 R H.HC.09 AF2 AF2
H.HC 131 L H.HC.10 AF2 AF2
H.HC 132 W H.HC.11 AF2 AF2
H.HC 133 A H.HC.12 AF2 AF2
H.hchd 134 D H.hchd.01 AF2 AF2
H.HD 135 H H.HD.01 AF2 AF2
H.HD 136 G H.HD.02 AF2 AF2
H.HD 137 V H.HD.03 AF2 AF2
H.HD 138 Q H.HD.04 AF2 AF2
H.HD 139 A H.HD.05 AF2 AF2
H.HD 140 C H.HD.06 AF2 AF2
H.HD 141 F H.HD.07 AF2 AF2
H.HD 142 G H.HD.08 AF2 AF2
H.HD 143 R H.HD.09 AF2 AF2
H.HD 144 S H.HD.10 AF2 AF2
H.HD 145 R H.HD.11 AF2 AF2
H.HD 146 E H.HD.12 AF2 AF2
H.hdhe 147 Y H.hdhe.01 AF2 AF2
H.hdhe 148 Q H.hdhe.02 AF2 AF2
H.hdhe 149 L H.hdhe.03 AF2 AF2
H.hdhe 150 N H.hdhe.04 AF2 AF2
H.hdhe 151 D H.hdhe.05 AF2 AF2
H.HE 152 S H.HE.01 AF2 AF2
H.HE 153 A H.HE.02 AF2 AF2
H.HE 154 A H.HE.03 AF2 AF2
H.HE 155 Y H.HE.04 AF2 AF2
H.HE 156 Y H.HE.05 AF2 AF2
H.HE 157 L H.HE.06 AF2 AF2
H.HE 158 N H.HE.07 AF2 AF2
H.HE 159 D H.HE.08 AF2 AF2
H.HE 160 L H.HE.09 AF2 AF2
H.HE 161 E H.HE.10 AF2 AF2
H.HE 162 R H.HE.11 AF2 AF2
H.HE 163 I H.HE.12 AF2 AF2
H.HE 164 A H.HE.13 AF2 AF2
H.hehf 165 Q H.hehf.01 AF2 AF2
H.hehf 166 S H.hehf.02 AF2 AF2
H.hehf 167 D H.hehf.03 AF2 AF2
H.hehf 168 Y H.hehf.04 AF2 AF2
H.hehf 169 I H.hehf.05 AF2 AF2
H.hehf 170 P H.hehf.06 AF2 AF2
H.hehf 171 T H.hehf.07 AF2 AF2
H.HF 172 Q H.HF.01 AF2 AF2
H.HF 173 Q H.HF.02 AF2 AF2
H.HF 174 D H.HF.03 AF2 AF2
H.HF 175 V H.HF.04 AF2 AF2
H.HF 176 L H.HF.05 AF2 AF2
H.HF 177 R H.HF.06 AF2 AF2
G.hfs2 178 T G.hfs2.01 AF2 AF2
G.hfs2 179 R G.hfs2.02 AF2 AF2
G.hfs2 180 V G.hfs2.03 AF2 AF2
G.hfs2 181 K G.hfs2.04 AF2 AF2
G.hfs2 182 T G.hfs2.05 AF2 AF2
G.hfs2 183 T G.hfs2.06 AF2 AF2
G.hfs2 184 G G.hfs2.07 Structure Structure
G.S2 185 I G.S2.01 Structure Structure
G.S2 186 V G.S2.02 Structure Structure
G.S2 187 E G.S2.03 Structure Structure
G.S2 188 T G.S2.04 Structure Structure
G.S2 189 H G.S2.05 Structure Structure
G.S2 190 F G.S2.06 Structure Structure
G.S2 191 T G.S2.07 Structure Structure
G.S2 192 F G.S2.08 Structure Structure
G.s2s3 193 K G.s2s3.01 Structure Structure
G.s2s3 194 D G.s2s3.02 Structure Structure
G.S3 195 L G.S3.01 Structure Structure
G.S3 196 H G.S3.02 Structure Structure
G.S3 197 F G.S3.03 Structure Structure
G.S3 198 K G.S3.04 Structure Structure
G.S3 199 M G.S3.05 Structure Structure
G.S3 200 F G.S3.06 Structure Structure
G.S3 201 D G.S3.07 Structure Structure
G.S3 202 V G.S3.08 Structure Structure
G.s3h2 203 G G.s3h2.01 Structure Structure
G.s3h2 204 G G.s3h2.02 Structure AF2
G.s3h2 205 Q G.s3h2.03 Structure Structure
G.H2 206 R G.H2.01 Structure AF2
G.H2 207 S G.H2.02 Structure Structure
G.H2 208 E G.H2.03 Structure Structure
G.H2 209 R G.H2.04 Structure Structure
G.H2 210 K G.H2.05 Structure Structure
G.H2 211 K G.H2.06 Structure Structure
G.H2 212 W G.H2.07 Structure Structure
G.H2 213 I G.H2.08 Structure Structure
G.H2 214 H G.H2.09 Structure Structure
G.H2 215 C G.H2.10 Structure Structure
G.h2s4 216 F G.h2s4.01 Structure Structure
G.h2s4 217 E G.h2s4.02 Structure Structure
G.h2s4 218 G G.h2s4.03 Structure Structure
G.h2s4 219 V G.h2s4.04 Structure Structure
G.h2s4 220 T G.h2s4.05 Structure Structure
G.S4 221 A G.S4.01 Structure Structure
G.S4 222 I G.S4.02 Structure Structure
G.S4 223 I G.S4.03 Structure Structure
G.S4 224 F G.S4.04 Structure Structure
G.S4 225 C G.S4.05 Structure Structure
G.S4 226 V G.S4.06 Structure Structure
G.S4 227 A G.S4.07 Structure Structure
G.s4h3 228 L G.s4h3.01 Structure Structure
G.s4h3 229 S G.s4h3.02 Structure Structure
G.s4h3 230 A G.s4h3.03 Structure Structure
G.s4h3 231 Y G.s4h3.04 Structure Structure
G.s4h3 232 D G.s4h3.05 Structure Structure
G.s4h3 233 L G.s4h3.06 Structure Structure
G.s4h3 234 V G.s4h3.07 Structure Structure
G.s4h3 235 L G.s4h3.08 Structure Structure
G.s4h3 236 A G.s4h3.09 Structure Structure
G.s4h3 237 E G.s4h3.10 AF2 AF2
G.s4h3 238 D G.s4h3.11 AF2 AF2
G.s4h3 239 E G.s4h3.12 AF2 AF2
G.s4h3 240 E G.s4h3.13 Structure Structure
G.s4h3 241 M G.s4h3.14 Structure Structure
G.s4h3 242 N G.s4h3.15 Structure Structure
G.H3 243 R G.H3.01 Structure Structure
G.H3 244 M G.H3.02 Structure Structure
G.H3 245 H G.H3.03 Structure Structure
G.H3 246 E G.H3.04 Structure AF2
G.H3 247 S G.H3.05 Structure Structure
G.H3 248 M G.H3.06 Structure Structure
G.H3 249 K G.H3.07 Structure Structure
G.H3 250 L G.H3.08 Structure Structure
G.H3 251 F G.H3.09 Structure Structure
G.H3 252 D G.H3.10 Structure Structure
G.H3 253 S G.H3.11 Structure Structure
G.H3 254 I G.H3.12 Structure Structure
G.H3 255 C G.H3.13 Structure Structure
G.H3 256 N G.H3.14 Structure Structure
G.H3 257 N G.H3.15 Structure Structure
G.H3 258 K G.H3.16 Structure Structure
G.H3 259 W G.H3.17 Structure Structure
G.H3 260 F G.H3.18 Structure Structure
G.h3s5 261 T G.h3s5.01 Structure Structure
G.h3s5 262 D G.h3s5.02 Structure Structure
G.h3s5 263 T G.h3s5.03 Structure Structure
G.S5 264 S G.S5.01 Structure Structure
G.S5 265 I G.S5.02 Structure Structure
G.S5 266 I G.S5.03 Structure Structure
G.S5 267 L G.S5.04 Structure Structure
G.S5 268 F G.S5.05 Structure Structure
G.S5 269 L G.S5.06 Structure Structure
G.S5 270 N G.S5.07 Structure Structure
G.s5hg 271 K G.s5hg.01 Structure Structure
G.HG 272 K G.HG.01 Structure Structure
G.HG 273 D G.HG.02 Structure Structure
G.HG 274 L G.HG.03 Structure Structure
G.HG 275 F G.HG.04 Structure Structure
G.HG 276 E G.HG.05 Structure Structure
G.HG 277 E G.HG.06 Structure Structure
G.HG 278 K G.HG.07 Structure Structure
G.HG 279 I G.HG.08 Structure Structure
G.HG 280 T G.HG.09 Structure Structure
G.HG 281 H G.HG.12 Structure Structure
G.HG 282 S G.HG.13 Structure Structure
G.HG 283 P G.HG.14 Structure Structure
G.HG 284 L G.HG.15 Structure Structure
G.HG 285 T G.HG.16 Structure Structure
G.HG 286 I G.HG.17 Structure Structure
G.hgh4 287 C G.hgh4.01 Structure Structure
G.hgh4 288 F G.hgh4.02 Structure Structure
G.hgh4 289 P G.hgh4.03 Structure Structure
G.hgh4 290 E G.hgh4.04 Structure Structure
G.hgh4 291 Y G.hgh4.05 Structure Structure
G.hgh4 292 T G.hgh4.06 Structure Structure
G.hgh4 293 G G.hgh4.07 Structure Structure
G.hgh4 294 A G.hgh4.08 Structure Structure
G.H4 295 N G.H4.01 Structure Structure
G.H4 296 K G.H4.02 Structure AF2
G.H4 297 Y G.H4.03 Structure Structure
G.H4 298 D G.H4.04 Structure Structure
G.H4 299 E G.H4.05 Structure Structure
G.H4 300 A G.H4.06 Structure Structure
G.H4 301 A G.H4.07 Structure Structure
G.H4 302 S G.H4.08 Structure Structure
G.H4 303 Y G.H4.10 Structure Structure
G.H4 304 I G.H4.11 Structure Structure
G.H4 305 Q G.H4.12 Structure Structure
G.H4 306 S G.H4.13 Structure Structure
G.H4 307 K G.H4.14 Structure Structure
G.H4 308 F G.H4.15 Structure Structure
G.H4 309 E G.H4.16 Structure Structure
G.H4 310 D G.H4.17 Structure Structure
G.h4s6 311 L G.h4s6.01 Structure Structure
G.h4s6 312 N G.h4s6.02 Structure Structure
G.h4s6 313 K G.h4s6.03 Structure Structure
G.h4s6 314 R G.h4s6.04 Structure Structure
G.h4s6 315 K G.h4s6.08 Structure Structure
G.h4s6 316 D G.h4s6.09 Structure Structure
G.h4s6 317 T G.h4s6.10 Structure Structure
G.h4s6 318 K G.h4s6.11 Structure Structure
G.h4s6 319 E G.h4s6.12 Structure Structure
G.S6 320 I G.S6.01 Structure Structure
G.S6 321 Y G.S6.02 Structure Structure
G.S6 322 T G.S6.03 Structure Structure
G.S6 323 H G.S6.04 Structure Structure
G.S6 324 F G.S6.05 Structure Structure
G.s6h5 325 T G.s6h5.01 Structure Structure
G.s6h5 326 C G.s6h5.02 Structure Structure
G.s6h5 327 A G.s6h5.03 Structure AF2
G.s6h5 328 T G.s6h5.04 Structure Structure
G.s6h5 329 D G.s6h5.05 Structure Structure
G.H5 330 T G.H5.01 Structure Structure
G.H5 331 K G.H5.02 Structure Structure
G.H5 332 N G.H5.03 Structure Structure
G.H5 333 V G.H5.04 Structure Structure
G.H5 334 Q G.H5.05 Structure Structure
G.H5 335 F G.H5.06 Structure Structure
G.H5 336 V G.H5.07 Structure Structure
G.H5 337 F G.H5.08 Structure Structure
G.H5 338 D G.H5.09 Structure Structure
G.H5 339 A G.H5.10 Structure Structure
G.H5 340 V G.H5.11 Structure Structure
G.H5 341 T G.H5.12 Structure Structure
G.H5 342 D G.H5.13 Structure Structure
G.H5 343 V G.H5.14 Structure Structure
G.H5 344 I G.H5.15 Structure Structure
G.H5 345 I G.H5.16 Structure Structure
G.H5 346 K G.H5.17 Structure Structure
G.H5 347 N G.H5.18 Structure Structure
G.H5 348 N G.H5.19 Structure Structure
G.H5 349 L G.H5.20 Structure Structure
G.H5 350 K G.H5.21 Structure Structure
G.H5 351 D G.H5.22 Structure Structure
G.H5 352 C G.H5.23 Structure Structure
G.H5 353 G G.H5.24 Structure Structure
G.H5 354 L G.H5.25 Structure Structure
G.H5 355 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 281 from structure (83.6%), 55 from model (16.4%)
Residue sidechains - 280 from structure (83.3%), 56 from model (16.7%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 P - AF2 AF2
N-term 3 T - AF2 AF2
N-term 4 L - AF2 AF2
N-term 5 N - AF2 AF2
N-term 6 T - AF2 AF2
N-term 7 S - AF2 AF2
N-term 8 A - AF2 AF2
N-term 9 S - AF2 AF2
N-term 10 P - AF2 AF2
N-term 11 P - AF2 AF2
N-term 12 T - AF2 AF2
N-term 13 F - AF2 AF2
N-term 14 F - AF2 AF2
N-term 15 W - AF2 AF2
N-term 16 A - AF2 AF2
N-term 17 N - AF2 AF2
N-term 18 A - AF2 AF2
N-term 19 S - AF2 AF2
N-term 20 G - AF2 AF2
N-term 21 G - AF2 AF2
N-term 22 S - AF2 AF2
N-term 23 V - AF2 AF2
N-term 24 L - AF2 AF2
N-term 25 S - AF2 AF2
N-term 26 A - AF2 AF2
N-term 27 D - AF2 AF2
N-term 28 D - AF2 AF2
N-term 29 A - AF2 AF2
N-term 30 P - AF2 AF2
N-term 31 M - AF2 AF2
N-term 32 P - AF2 AF2
N-term 33 V - AF2 AF2
N-term 34 K - AF2 AF2
TM1 35 F 1.28x28 Structure Structure
TM1 36 L 1.29x29 Structure Structure
TM1 37 A 1.30x30 Structure Structure
TM1 38 L 1.31x31 Structure Structure
TM1 39 R 1.32x32 Structure Structure
TM1 40 L 1.33x33 Structure Structure
TM1 41 M 1.34x34 Structure Structure
TM1 42 V 1.35x35 Structure Structure
TM1 43 A 1.36x36 Structure Structure
TM1 44 L 1.37x37 Structure Structure
TM1 45 A 1.38x38 Structure Structure
TM1 46 Y 1.39x39 Structure Structure
TM1 47 G 1.40x40 Structure Structure
TM1 48 L 1.41x41 Structure Structure
TM1 49 V 1.42x42 Structure Structure
TM1 50 G 1.43x43 Structure Structure
TM1 51 A 1.44x44 Structure Structure
TM1 52 I 1.45x45 Structure Structure
TM1 53 G 1.46x46 Structure Structure
TM1 54 L 1.47x47 Structure Structure
TM1 55 L 1.48x48 Structure Structure
TM1 56 G 1.49x49 Structure Structure
TM1 57 N 1.50x50 Structure Structure
TM1 58 L 1.51x51 Structure Structure
TM1 59 A 1.52x52 Structure Structure
TM1 60 V 1.53x53 Structure Structure
TM1 61 L 1.54x54 Structure Structure
TM1 62 W 1.55x55 Structure Structure
TM1 63 V 1.56x56 Structure Structure
TM1 64 L 1.57x57 Structure Structure
TM1 65 S 1.58x58 Structure Structure
TM1 66 N 1.59x59 AF2 AF2
TM1 67 C 1.60x60 AF2 AF2
ICL1 68 A - AF2 AF2
ICL1 69 R 12.48x48 AF2 AF2
ICL1 70 R 12.49x49 AF2 AF2
ICL1 71 A 12.50x50 AF2 AF2
ICL1 72 P 12.51x51 AF2 AF2
TM2 73 G 2.36x36 Structure Structure
TM2 74 P 2.37x37 Structure Structure
TM2 75 P 2.38x38 Structure Structure
TM2 76 S 2.39x39 Structure Structure
TM2 77 D 2.40x40 Structure Structure
TM2 78 T 2.41x41 Structure Structure
TM2 79 F 2.42x42 Structure Structure
TM2 80 V 2.43x43 Structure Structure
TM2 81 F 2.44x44 Structure Structure
TM2 82 N 2.45x45 Structure Structure
TM2 83 L 2.46x46 Structure Structure
TM2 84 A 2.47x47 Structure Structure
TM2 85 L 2.48x48 Structure Structure
TM2 86 A 2.49x49 Structure Structure
TM2 87 D 2.50x50 Structure Structure
TM2 88 L 2.51x51 Structure Structure
TM2 89 G 2.52x52 Structure Structure
TM2 90 L 2.53x53 Structure Structure
TM2 91 A 2.54x54 Structure Structure
TM2 92 L 2.55x55 Structure Structure
TM2 93 T 2.56x56 Structure Structure
TM2 94 L 2.57x57 Structure Structure
TM2 95 P 2.58x58 Structure Structure
TM2 96 F 2.59x59 Structure Structure
TM2 97 W 2.60x60 Structure Structure
TM2 98 A 2.61x61 Structure Structure
TM2 99 A 2.62x62 Structure Structure
TM2 100 E 2.63x63 Structure Structure
TM2 101 S 2.64x64 Structure Structure
TM2 102 A 2.65x65 Structure Structure
TM2 103 L 2.66x66 Structure Structure
TM2 104 D 2.67x67 Structure Structure
ECL1 105 F - Structure Structure
ECL1 106 H 23.49x49 Structure Structure
ECL1 107 W 23.50x50 Structure Structure
ECL1 108 P 23.51x51 Structure Structure
ECL1 109 F 23.52x52 Structure Structure
TM3 110 G 3.21x21 Structure Structure
TM3 111 G 3.22x22 Structure Structure
TM3 112 A 3.23x23 Structure Structure
TM3 113 L 3.24x24 Structure Structure
TM3 114 C 3.25x25 Structure Structure
TM3 115 K 3.26x26 Structure Structure
TM3 116 M 3.27x27 Structure AF2
TM3 117 V 3.28x28 Structure Structure
TM3 118 L 3.29x29 Structure Structure
TM3 119 T 3.30x30 Structure Structure
TM3 120 A 3.31x31 Structure Structure
TM3 121 T 3.32x32 Structure Structure
TM3 122 V 3.33x33 Structure Structure
TM3 123 L 3.34x34 Structure Structure
TM3 124 N 3.35x35 Structure Structure
TM3 125 V 3.36x36 Structure Structure
TM3 126 Y 3.37x37 Structure Structure
TM3 127 A 3.38x38 Structure Structure
TM3 128 S 3.39x39 Structure Structure
TM3 129 I 3.40x40 Structure Structure
TM3 130 F 3.41x41 Structure Structure
TM3 131 L 3.42x42 Structure Structure
TM3 132 I 3.43x43 Structure Structure
TM3 133 T 3.44x44 Structure Structure
TM3 134 A 3.45x45 Structure Structure
TM3 135 L 3.46x46 Structure Structure
TM3 136 S 3.47x47 Structure Structure
TM3 137 V 3.48x48 Structure Structure
TM3 138 A 3.49x49 Structure Structure
TM3 139 R 3.50x50 Structure Structure
TM3 140 Y 3.51x51 Structure Structure
TM3 141 W 3.52x52 Structure Structure
TM3 142 V 3.53x53 Structure Structure
TM3 143 V 3.54x54 Structure Structure
TM3 144 A 3.55x55 Structure Structure
TM3 145 M 3.56x56 Structure Structure
ICL2 146 A 34.50x50 Structure Structure
ICL2 147 A 34.51x51 Structure Structure
ICL2 148 G 34.52x52 Structure Structure
ICL2 149 P 34.53x53 Structure Structure
ICL2 150 G 34.54x54 Structure Structure
ICL2 151 T 34.55x55 Structure Structure
ICL2 152 H 34.56x56 Structure Structure
ICL2 153 L 34.57x57 Structure Structure
TM4 154 S 4.38x38 Structure Structure
TM4 155 L 4.39x39 Structure Structure
TM4 156 F 4.40x40 Structure Structure
TM4 157 W 4.41x41 Structure Structure
TM4 158 A 4.42x42 Structure Structure
TM4 159 R 4.43x43 Structure Structure
TM4 160 I 4.44x44 Structure Structure
TM4 161 A 4.45x45 Structure Structure
TM4 162 T 4.46x46 Structure Structure
TM4 163 L 4.47x47 Structure Structure
TM4 164 A 4.48x48 Structure Structure
TM4 165 V 4.49x49 Structure Structure
TM4 166 W 4.50x50 Structure Structure
TM4 167 A 4.51x51 Structure Structure
TM4 168 A 4.52x52 Structure Structure
TM4 169 A 4.53x53 Structure Structure
TM4 170 A 4.54x54 Structure Structure
TM4 171 L 4.55x55 Structure Structure
TM4 172 V 4.56x56 Structure Structure
TM4 173 T 4.57x57 Structure Structure
TM4 174 V 4.58x59 Structure Structure
TM4 175 P 4.59x60 Structure Structure
TM4 176 T 4.60x61 Structure Structure
TM4 177 A 4.61x62 Structure Structure
TM4 178 V 4.62x63 Structure Structure
TM4 179 F 4.63x64 Structure Structure
TM4 180 G 4.64x65 Structure Structure
ECL2 181 V - Structure Structure
ECL2 182 E - Structure Structure
ECL2 183 G - Structure Structure
ECL2 184 E - Structure Structure
ECL2 185 V - Structure Structure
ECL2 186 C - Structure Structure
ECL2 187 G - Structure Structure
ECL2 188 V - Structure Structure
ECL2 189 R - Structure Structure
ECL2 190 L - Structure Structure
ECL2 191 C 45.50x50 Structure Structure
ECL2 192 L 45.51x51 Structure Structure
ECL2 193 L 45.52x52 Structure Structure
ECL2 194 R - Structure Structure
ECL2 195 F - Structure Structure
ECL2 196 P - Structure Structure
ECL2 197 S - Structure Structure
ECL2 198 R - Structure Structure
TM5 199 Y 5.33x34 Structure Structure
TM5 200 W 5.34x35 Structure Structure
TM5 201 L 5.35x36 Structure Structure
TM5 202 G 5.36x37 Structure Structure
TM5 203 A 5.37x38 Structure Structure
TM5 204 Y 5.38x39 Structure Structure
TM5 205 Q 5.39x40 Structure Structure
TM5 206 L 5.40x41 Structure Structure
TM5 207 Q 5.41x42 Structure Structure
TM5 208 R 5.42x43 Structure Structure
TM5 209 V 5.43x44 Structure Structure
TM5 210 V 5.44x45 Structure Structure
TM5 211 L 5.45x46 Structure Structure
TM5 212 A 5.46x461 Structure Structure
TM5 213 F 5.47x47 Structure Structure
TM5 214 M 5.48x48 Structure Structure
TM5 215 V 5.49x49 Structure Structure
TM5 216 P 5.50x50 Structure Structure
TM5 217 L 5.51x51 Structure Structure
TM5 218 G 5.52x52 Structure Structure
TM5 219 V 5.53x53 Structure Structure
TM5 220 I 5.54x54 Structure Structure
TM5 221 T 5.55x55 Structure Structure
TM5 222 T 5.56x56 Structure Structure
TM5 223 S 5.57x57 Structure Structure
TM5 224 Y 5.58x58 Structure Structure
TM5 225 L 5.59x59 Structure Structure
TM5 226 L 5.60x60 Structure Structure
TM5 227 L 5.61x61 Structure Structure
TM5 228 L 5.62x62 Structure Structure
TM5 229 A 5.63x63 Structure Structure
TM5 230 F 5.64x64 Structure Structure
TM5 231 L 5.65x65 Structure Structure
TM5 232 Q 5.66x66 Structure Structure
TM5 233 R 5.67x67 Structure Structure
TM5 234 R 5.68x68 Structure Structure
ICL3 235 Q - Structure Structure
ICL3 236 R - Structure Structure
TM6 237 R 6.26x26 Structure Structure
TM6 238 R 6.27x27 Structure Structure
TM6 239 Q 6.28x28 Structure Structure
TM6 240 D 6.29x29 Structure Structure
TM6 241 S 6.30x30 Structure Structure
TM6 242 R 6.31x31 Structure Structure
TM6 243 V 6.32x32 Structure Structure
TM6 244 V 6.33x33 Structure Structure
TM6 245 A 6.34x34 Structure Structure
TM6 246 R 6.35x35 Structure Structure
TM6 247 S 6.36x36 Structure Structure
TM6 248 V 6.37x37 Structure Structure
TM6 249 R 6.38x38 Structure Structure
TM6 250 I 6.39x39 Structure Structure
TM6 251 L 6.40x40 Structure Structure
TM6 252 V 6.41x41 Structure Structure
TM6 253 A 6.42x42 Structure Structure
TM6 254 S 6.43x43 Structure Structure
TM6 255 F 6.44x44 Structure Structure
TM6 256 F 6.45x45 Structure Structure
TM6 257 L 6.46x46 Structure Structure
TM6 258 C 6.47x47 Structure Structure
TM6 259 W 6.48x48 Structure Structure
TM6 260 F 6.49x49 Structure Structure
TM6 261 P 6.50x50 Structure Structure
TM6 262 N 6.51x51 Structure Structure
TM6 263 H 6.52x52 Structure Structure
TM6 264 V 6.53x53 Structure Structure
TM6 265 V 6.54x54 Structure Structure
TM6 266 T 6.55x55 Structure Structure
TM6 267 L 6.56x56 Structure Structure
TM6 268 W 6.57x57 Structure Structure
TM6 269 G 6.58x58 Structure Structure
TM6 270 V 6.59x59 Structure Structure
TM6 271 L 6.60x60 Structure Structure
TM6 272 V 6.61x61 Structure Structure
TM6 273 K 6.62x62 Structure Structure
TM6 274 F 6.63x63 Structure Structure
TM6 275 D 6.64x64 Structure Structure
TM6 276 L 6.65x65 Structure Structure
ECL3 277 V - Structure Structure
ECL3 278 P - Structure Structure
ECL3 279 W - Structure Structure
ECL3 280 N - Structure Structure
ECL3 281 S - Structure Structure
TM7 282 T 7.26x25 Structure Structure
TM7 283 F 7.27x26 Structure Structure
TM7 284 Y 7.28x27 Structure Structure
TM7 285 T 7.29x28 Structure Structure
TM7 286 I 7.30x29 Structure Structure
TM7 287 Q 7.31x30 Structure Structure
TM7 288 T 7.32x31 Structure Structure
TM7 289 Y 7.33x32 Structure Structure
TM7 290 V 7.34x33 Structure Structure
TM7 291 F 7.35x34 Structure Structure
TM7 292 P 7.36x35 Structure Structure
TM7 293 V 7.37x36 Structure Structure
TM7 294 T 7.38x37 Structure Structure
TM7 295 T 7.39x38 Structure Structure
TM7 296 C 7.40x39 Structure Structure
TM7 297 L 7.41x40 Structure Structure
TM7 298 A 7.42x41 Structure Structure
TM7 299 H 7.43x42 Structure Structure
TM7 300 S 7.44x43 Structure Structure
TM7 301 N 7.45x45 Structure Structure
TM7 302 S 7.46x46 Structure Structure
TM7 303 C 7.47x47 Structure Structure
TM7 304 L 7.48x48 Structure Structure
TM7 305 N 7.49x49 Structure Structure
TM7 306 P 7.50x50 Structure Structure
TM7 307 V 7.51x51 Structure Structure
TM7 308 L 7.52x52 Structure Structure
TM7 309 Y 7.53x53 Structure Structure
TM7 310 C 7.54x54 Structure Structure
TM7 311 L 7.55x55 Structure Structure
TM7 312 L 7.56x56 Structure Structure
H8 313 R 8.47x47 Structure Structure
H8 314 R 8.48x48 Structure Structure
H8 315 E 8.49x49 Structure Structure
H8 316 P 8.50x50 Structure Structure
H8 317 R 8.51x51 Structure Structure
H8 318 Q 8.52x52 Structure Structure
H8 319 A 8.53x53 Structure Structure
H8 320 L 8.54x54 Structure Structure
H8 321 A 8.55x55 Structure Structure
H8 322 G 8.56x56 Structure Structure
H8 323 T 8.57x57 AF2 AF2
H8 324 F 8.58x58 AF2 AF2
H8 325 R 8.59x59 AF2 AF2
H8 326 D 8.60x60 AF2 AF2
C-term 327 L - AF2 AF2
C-term 328 R - AF2 AF2
C-term 329 L - AF2 AF2
C-term 330 R - AF2 AF2
C-term 331 L - AF2 AF2
C-term 332 W - AF2 AF2
C-term 333 P - AF2 AF2
C-term 334 Q - AF2 AF2
C-term 335 G - AF2 AF2
C-term 336 G - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 R 139 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 139 3x50 G.H5 C 352 G.H5.23
Polar ICL2 G 150 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 G 150 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 G 150 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic TM6 D 240 6x29 G.H5 F 355 G.H5.26
Van-der-waals TM6 D 240 6x29 G.H5 F 355 G.H5.26
Polar TM6 S 247 6x36 G.H5 L 354 G.H5.25
Hydrophobic ICL2 P 149 34x53 G.S3 L 195 G.S3.01
Polar ICL3 Q 235 - G.H5 D 338 G.H5.09
Hydrophobic H8 R 313 8x47 G.H5 G 353 G.H5.24
Hydrophobic TM3 V 143 3x54 G.H5 N 348 G.H5.19
Hydrophobic TM5 Y 224 5x58 G.H5 L 354 G.H5.25
Hydrophobic TM5 L 227 5x61 G.H5 L 354 G.H5.25
Hydrophobic TM3 V 142 3x53 G.H5 C 352 G.H5.23
Van-der-waals TM3 V 142 3x53 G.H5 C 352 G.H5.23
Polar ICL3 Q 235 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 Q 235 - G.H5 D 342 G.H5.13
Hydrophobic ICL3 R 236 - G.S6 Y 321 G.S6.02
Hydrophobic TM5 L 231 5x65 G.H5 L 349 G.H5.20
Van-der-waals TM5 L 231 5x65 G.H5 L 349 G.H5.20
Hydrophobic TM3 R 139 3x50 G.H5 L 354 G.H5.25
Ionic TM6 R 237 6x26 G.H5 D 342 G.H5.13
Polar TM6 R 237 6x26 G.H5 D 342 G.H5.13
Hydrophobic ICL2 G 148 34x52 G.H5 I 344 G.H5.15
Hydrophobic TM6 D 240 6x29 G.H5 L 349 G.H5.20
Van-der-waals TM6 D 240 6x29 G.H5 L 349 G.H5.20
Hydrophobic TM5 R 234 5x68 G.H5 I 345 G.H5.16
Hydrophobic TM6 V 244 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 V 244 6x33 G.H5 L 354 G.H5.25
Hydrophobic ICL2 P 149 34x53 G.S1 V 34 G.S1.02
Van-der-waals ICL2 P 149 34x53 G.S1 V 34 G.S1.02
Hydrophobic TM5 L 231 5x65 G.H5 I 345 G.H5.16
Hydrophobic ICL2 G 148 34x52 G.S3 L 195 G.S3.01
Hydrophobic ICL2 P 149 34x53 G.S1 E 33 G.S1.01
Van-der-waals ICL2 P 149 34x53 G.S1 E 33 G.S1.01
Hydrophobic TM3 V 143 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 V 143 3x54 G.H5 L 349 G.H5.20
Hydrophobic TM6 R 237 6x26 G.H5 I 345 G.H5.16
Hydrophobic ICL2 P 149 34x53 G.H5 I 344 G.H5.15
Hydrophobic TM5 F 230 5x64 G.H5 I 345 G.H5.16
Van-der-waals TM5 F 230 5x64 G.H5 I 345 G.H5.16
Polar TM3 V 142 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 V 142 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 V 142 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM6 R 237 6x26 G.H5 K 346 G.H5.17
Hydrophobic TM6 V 244 6x33 G.H5 L 349 G.H5.20
Polar ICL2 H 152 34x56 G.H5 N 348 G.H5.19
Hydrophobic ICL2 H 152 34x56 G.H5 N 348 G.H5.19
Van-der-waals ICL2 H 152 34x56 G.H5 N 348 G.H5.19
Hydrophobic ICL2 A 147 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 A 147 34x51 G.S3 L 195 G.S3.01
Hydrophobic TM6 V 243 6x32 G.H5 F 355 G.H5.26
Van-der-waals TM6 V 243 6x32 G.H5 F 355 G.H5.26
Hydrophobic ICL2 P 149 34x53 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 P 149 34x53 G.hns1 R 32 G.hns1.03