δ receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.1 Å

REFERENCE

PUBLICATION DATE

March 4, 2026

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

Met-enkephalin - Agonist

PHYSIOLOGICAL LIGANDS

[Met]enkephalin (Human), dynorphin A (Human), dynorphin A-(1-8) (Human), dynorphin A-(1-13) (Human), β-endorphin (Mouse), endomorphin-1 (Human), β-endorphin (Rat), dynorphin B (Human), β-endorphin (Human), α-neoendorphin (Human), [Leu]enkephalin (Human)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Hydrophobic TM3 V 150 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 150 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 153 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM6 S 255 6x29 G.H5 F 354 G.H5.26
Polar TM2 T 84 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM2 T 84 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 84 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM3 R 146 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 146 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 A 149 3x53 G.H5 C 351 G.H5.23
Polar H8 E 323 8x48 G.H5 G 352 G.H5.24
Hydrophobic H8 E 323 8x48 G.H5 G 352 G.H5.24
Van-der-waals H8 E 323 8x48 G.H5 G 352 G.H5.24
Polar ICL2 L 157 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 157 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 L 240 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM5 V 243 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 V 243 5x68 G.H5 D 341 G.H5.13
Hydrophobic ICL2 P 153 34x50 G.H5 T 340 G.H5.12
Hydrophobic ICL2 D 158 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic H8 D 322 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 D 322 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 N 324 8x49 G.H5 G 352 G.H5.24
Hydrophobic TM2 T 84 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 84 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM5 M 236 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 M 236 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM6 I 259 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM6 I 259 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 259 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 V 154 34x51 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 V 154 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 L 157 34x54 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 157 34x54 G.S3 L 194 G.S3.01
Polar H8 N 324 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 N 324 8x49 G.H5 D 350 G.H5.22
Ionic ICL2 R 160 34x57 G.H5 D 350 G.H5.22
Polar ICL2 R 160 34x57 G.H5 D 350 G.H5.22
Hydrophobic ICL2 R 160 34x57 G.H5 D 350 G.H5.22
Van-der-waals ICL2 R 160 34x57 G.H5 D 350 G.H5.22
Hydrophobic TM6 M 262 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 M 262 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 157 34x54 G.H5 I 343 G.H5.15
Polar TM3 R 146 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 146 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 146 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 V 154 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM6 I 259 6x33 G.H5 F 354 G.H5.26
Polar TM3 A 149 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 149 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 149 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 L 240 5x65 G.H5 I 344 G.H5.16
Polar ICL2 R 160 34x57 G.H5 C 351 G.H5.23
Hydrophobic ICL2 R 160 34x57 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 150 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 V 150 3x54 G.H5 I 344 G.H5.16
Polar ICL2 R 160 34x57 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 153 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM2 T 82 2x37 G.H5 D 350 G.H5.22