PDB
9PPY
Resolution
3.1 Å
Released
March 4, 2026
Receptor
δ
Class
A
Species
Homo sapiens
Ligand
Function
Met-enkephalin
Agonist
Reference
10.1126/SCIADV.AEB6737

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Ligand Amino Acid Generic Number Segment Interaction Type
Met-enkephalin T101 2.56x56 TM2 Van der Waals
Met-enkephalin Q105 2.60x60 TM2 hydrophobic
Met-enkephalin K108 2.63x63 TM2 Van der Waals
Met-enkephalin W114 23.50x50 ECL1 hydrophobic
Met-enkephalin V124 3.28x28 TM3 hydrophobic
Met-enkephalin L125 3.29x29 TM3 hydrophobic
Met-enkephalin D128 3.32x32 TM3 polar (charge-charge)
Met-enkephalin Y129 3.33x33 TM3 hydrophobic
Met-enkephalin Y129 3.33x33 TM3 aromatic (edge-to-face)
Met-enkephalin Y129 3.33x33 TM3 aromatic (pi-cation)
Met-enkephalin M132 3.36x36 TM3 hydrophobic
Met-enkephalin C198 45.50x50 ECL2 Van der Waals
Met-enkephalin M199 45.51x51 ECL2 Van der Waals
Met-enkephalin K214 5.39x40 TM5 Van der Waals
Met-enkephalin V217 5.42x43 TM5 hydrophobic
Met-enkephalin I277 6.51x51 TM6 Van der Waals
Met-enkephalin V281 6.55x55 TM6 hydrophobic
Met-enkephalin I304 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 V T R P R D G A V V C M L Q F P S ECL2ICL3 R L L S G ICL3ECL3 D I D R R ECL3N-term M E P A P S A G A E L Q P P L F A N A S D A Y P S A C P S A G A N A S G P P N-termC-term P C G R P D P S S F S R A R E A T A R E R V T A C T P S D G P G G G A A A C-term G A R S A S S L A L A I A I T A L Y S A V C A V G L L G N V L V M F G I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S A K Y L M E G E L L C K A V L S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H T P A K A K L I N I C I W V L A S G V G V P I M V M A P S W Y W D T V T K I C V F L F A F V V P I L I I T V C Y G L M L L R L R S V S K E K D R S L R R I T R M V L V V V G A F V V C W A P I H I F V I V W T L V D P L V V A A L H L C I A L G Y A N S S L N P V L Y A F L D E N F R Q F K R C L C R K
Helix box plot — Download: PNG | SVG V N G L L G V A C V A S Y L A T I A I A 1 F N L A L A D A L A T S T L P F Q S A K 2 M T L T F I S T F M N Y Y D I S L V A K 3 A K L I N I C I W V L A S G V G V P I M 4 Y C V T I I L I P V V F A F L F V C I K T 5 L V V V G A F V V C W A P I H I F V I V 6 V P N L S S N A Y G L A I C L H L A A 7

GPCRdb(A)
GPCRdb(A)
δ receptor
TM2
2x56 2.56x56 T101
2x60 2.60x60 Q105
2x63 2.63x63 K108
ECL1
23x50 23.50x50 W114
TM3
3x28 3.28x28 V124
3x29 3.29x29 L125
3x32 3.32x32 D128
3x33 3.33x33 Y129
3x36 3.36x36 M132
ECL2
45x50 45.50x50 C198
45x51 45.51x51 M199
TM5
5x40 5.39x40 K214
5x43 5.42x43 V217
TM6
6x51 6.51x51 I277
6x55 6.55x55 V281
TM7
7x38 7.39x38 I304