H1 receptor - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.8 Å

REFERENCE

PUBLICATION DATE

June 11, 2025

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

PHYSIOLOGICAL LIGANDS

histamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Polar TM5 Q 219 5x67 G.H5 Q 374 G.H5.16
Van-der-waals TM5 Q 219 5x67 G.H5 Q 374 G.H5.16
Ionic TM5 H 220 5x68 G.H5 D 371 G.H5.13
Polar TM5 H 220 5x68 G.H5 D 371 G.H5.13
Hydrophobic TM5 H 220 5x68 G.H5 D 371 G.H5.13
Van-der-waals TM5 H 220 5x68 G.H5 D 371 G.H5.13
Hydrophobic TM6 A 413 6x33 G.H5 L 383 G.H5.25
Van-der-waals TM6 A 413 6x33 G.H5 L 383 G.H5.25
Aromatic TM3 R 125 3x50 G.H5 Y 381 G.H5.23
Hydrophobic TM3 R 125 3x50 G.H5 Y 381 G.H5.23
Van-der-waals TM3 R 125 3x50 G.H5 Y 381 G.H5.23
Hydrophobic ICL2 L 136 - G.hns1 A 39 G.hns1.03
Polar ICL2 K 137 - G.S3 N 218 G.S3.02
Hydrophobic TM5 I 213 5x61 G.H5 L 383 G.H5.25
Hydrophobic TM6 L 417 6x37 G.H5 L 383 G.H5.25
Polar TM5 H 220 5x68 G.H5 R 375 G.H5.17
Aromatic TM5 H 220 5x68 G.H5 R 375 G.H5.17
Hydrophobic TM5 H 220 5x68 G.H5 R 375 G.H5.17
Hydrophobic TM3 V 129 3x54 G.H5 L 378 G.H5.20
Van-der-waals TM3 V 129 3x54 G.H5 L 378 G.H5.20
Hydrophobic ICL2 P 132 - G.H5 I 373 G.H5.15
Van-der-waals ICL2 P 132 - G.H5 I 373 G.H5.15
Polar TM3 Q 130 3x55 G.H5 R 370 G.H5.12
Van-der-waals TM3 Q 130 3x55 G.H5 R 370 G.H5.12
Hydrophobic ICL2 L 133 - G.S3 V 217 G.S3.01
Hydrophobic TM6 K 412 6x32 G.H5 L 383 G.H5.25
Hydrophobic TM5 V 217 5x65 G.H5 L 378 G.H5.20
Van-der-waals TM5 V 217 5x65 G.H5 L 378 G.H5.20
Hydrophobic ICL2 L 133 - G.H5 C 369 G.H5.11
Van-der-waals TM7 C 471 7x56 G.H5 E 382 G.H5.24
Hydrophobic ICL2 L 133 - G.H5 I 373 G.H5.15
Van-der-waals ICL2 L 133 - G.H5 I 373 G.H5.15
Hydrophobic TM5 V 217 5x65 G.H5 L 383 G.H5.25
Polar TM5 H 220 5x68 G.H5 Q 374 G.H5.16
Hydrophobic TM5 H 220 5x68 G.H5 Q 374 G.H5.16
Van-der-waals TM5 H 220 5x68 G.H5 Q 374 G.H5.16
Hydrophobic ICL2 L 136 - G.H5 I 373 G.H5.15
Hydrophobic TM6 K 412 6x32 G.H5 E 382 G.H5.24
Hydrophobic ICL2 P 132 - G.H5 H 377 G.H5.19
Polar TM3 V 129 3x54 G.H5 Q 374 G.H5.16
Hydrophobic TM3 V 129 3x54 G.H5 Q 374 G.H5.16
Van-der-waals TM3 V 129 3x54 G.H5 Q 374 G.H5.16
Hydrophobic ICL2 R 134 - G.H5 R 370 G.H5.12
Van-der-waals ICL2 R 134 - G.H5 R 370 G.H5.12
Hydrophobic TM4 T 140 4x38 G.HN Q 35 G.HN.52
Van-der-waals TM4 T 140 4x38 G.HN Q 35 G.HN.52
Hydrophobic ICL2 R 134 - G.H5 F 366 G.H5.08
Hydrophobic TM5 C 221 5x69 G.H5 L 384 G.H5.26
Van-der-waals TM5 C 221 5x69 G.H5 L 384 G.H5.26
Hydrophobic TM3 V 129 3x54 G.H5 Y 381 G.H5.23
Hydrophobic ICL2 P 132 - G.H5 R 370 G.H5.12
Polar ICL2 K 137 - G.s2s3 K 216 G.s2s3.02
Van-der-waals ICL2 K 137 - G.s2s3 K 216 G.s2s3.02
Polar TM6 K 412 6x32 G.H5 L 384 G.H5.26
Hydrophobic TM6 K 412 6x32 G.H5 L 384 G.H5.26
Van-der-waals TM6 K 412 6x32 G.H5 L 384 G.H5.26
Polar TM3 S 128 3x53 G.H5 Y 381 G.H5.23
Hydrophobic TM3 S 128 3x53 G.H5 Y 381 G.H5.23
Van-der-waals TM3 S 128 3x53 G.H5 Y 381 G.H5.23
Hydrophobic ICL2 L 133 - G.H5 R 370 G.H5.12
Van-der-waals ICL2 L 133 - G.H5 R 370 G.H5.12
Hydrophobic ICL2 K 137 - G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 L 136 - G.H5 H 377 G.H5.19
Hydrophobic ICL2 P 132 - G.H5 Q 374 G.H5.16
Hydrophobic TM6 Q 416 6x36 G.H5 L 383 G.H5.25
Van-der-waals TM6 Q 416 6x36 G.H5 L 383 G.H5.25
Hydrophobic TM5 I 213 5x61 G.H5 L 378 G.H5.20
Polar TM3 S 128 3x53 G.H5 H 377 G.H5.19
Van-der-waals TM3 S 128 3x53 G.H5 H 377 G.H5.19
Hydrophobic ICL2 L 133 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 133 - G.S1 H 41 G.S1.02
Aromatic ICL2 R 139 - G.H5 H 377 G.H5.19
Hydrophobic ICL2 L 133 - G.H5 F 366 G.H5.08
Van-der-waals ICL2 L 133 - G.H5 F 366 G.H5.08
Hydrophobic ICL2 R 134 - G.S3 V 217 G.S3.01
Hydrophobic TM5 H 220 5x68 G.H5 L 378 G.H5.20
Van-der-waals TM5 H 220 5x68 G.H5 L 378 G.H5.20
Polar ICL2 R 139 - G.H5 Y 381 G.H5.23
Van-der-waals ICL2 R 139 - G.H5 Y 381 G.H5.23
Polar TM6 Q 416 6x36 G.H5 Y 381 G.H5.23
Polar TM6 Q 416 6x36 G.H5 E 382 G.H5.24