GHRH receptor - Gs

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

2.9 Å

REFERENCE

PUBLICATION DATE

July 8, 2026

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

PCO371 - Allosteric agonist pubchem gtoplig chembl_ligand drugbank

PHYSIOLOGICAL LIGANDS

GHRH (Mouse), GHRH (Rat), GHRH (Human)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Polar H8 E 382 8x49 G.H5 E 392 G.H5.24
Van-der-waals H8 E 382 8x49 G.H5 E 392 G.H5.24
Hydrophobic ICL2 T 234 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 T 234 - G.S3 V 217 G.S3.01
Hydrophobic TM5 K 310 5x64 G.H5 L 394 G.H5.26
Polar TM3 L 230 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 230 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 230 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM6 L 334 6x45 G.H5 L 393 G.H5.25
Hydrophobic TM3 L 230 3x57 G.H5 Y 391 G.H5.23
Hydrophobic TM6 R 326 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM5 L 307 5x61 G.H5 L 388 G.H5.20
Polar TM5 K 310 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 K 310 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 K 310 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM3 L 231 3x58 G.H5 L 388 G.H5.20
Polar TM2 R 161 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 161 2x46 G.H5 Q 390 G.H5.22
Van-der-waals TM2 R 161 2x46 G.H5 Q 390 G.H5.22
Polar TM3 L 231 3x58 G.H5 R 380 G.H5.12
Polar TM3 L 231 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 231 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 231 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM5 L 307 5x61 G.H5 L 394 G.H5.26
Polar ICL2 T 234 - G.S1 H 41 G.S1.02
Polar TM6 S 330 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM6 S 330 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 S 330 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM5 L 311 5x65 G.H5 L 394 G.H5.26
Van-der-waals TM5 L 311 5x65 G.H5 L 394 G.H5.26
Polar TM5 K 310 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 310 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 310 5x64 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 P 236 - G.H5 I 383 G.H5.15
Aromatic TM2 R 161 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 161 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 161 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 227 3x54 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 227 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM5 K 310 5x64 G.H5 L 388 G.H5.20
Hydrophobic TM6 R 326 6x37 G.H5 L 394 G.H5.26
Van-der-waals H8 N 380 8x47 G.H5 E 392 G.H5.24
Polar TM6 R 326 6x37 G.H5 E 392 G.H5.24
Hydrophobic TM6 R 326 6x37 G.H5 E 392 G.H5.24
Van-der-waals TM6 R 326 6x37 G.H5 E 392 G.H5.24
Hydrophobic TM3 L 227 3x54 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 236 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 P 236 - G.S1 H 41 G.S1.02
Ionic TM5 K 310 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 310 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 310 5x64 G.H5 D 381 G.H5.13
Hydrophobic ICL2 T 234 - G.H5 F 376 G.H5.08
Polar H8 Q 381 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 Q 381 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 Q 381 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM5 L 307 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 L 307 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM2 H 165 2x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 Y 226 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 S 237 - G.hns1 R 38 G.hns1.02
Hydrophobic TM3 L 231 3x58 G.H5 H 387 G.H5.19
Hydrophobic ICL2 T 234 - G.H5 R 380 G.H5.12