HCA2 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Mus musculus

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8UUJ

RESOLUTION

2.6 Å

REFERENCE

10.1016/J.CELL.2024.11.001

PUBLICATION DATE

Feb. 26, 2025

3D VIEW

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LIGAND INTERACTIONS

30 interactions (Click to see)

LIGANDS

compound (+)17a [PMID: 20363624] - Agonist pubchem gtoplig chembl_ligand chembl_ligand pubchem pubchem

PHYSIOLOGICAL LIGANDS

β-D-hydroxybutyric acid



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 V 126 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 126 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 H 130 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 H 130 - G.S3 L 194 G.S3.01
Hydrophobic TM3 R 122 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 H 130 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 H 130 - G.H5 I 343 G.H5.15
Hydrophobic TM5 R 215 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM6 R 219 6x26 G.H5 K 349 G.H5.21
Van-der-waals TM6 R 219 6x26 G.H5 K 349 G.H5.21
Polar TM6 A 226 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 226 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 226 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 226 6x33 G.H5 F 354 G.H5.26
Ionic TM2 K 57 2x37 G.H5 D 350 G.H5.22
Polar TM2 K 57 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 K 57 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 K 57 2x37 G.H5 D 350 G.H5.22
Hydrophobic ICL2 H 130 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 H 130 - G.H5 T 340 G.H5.12
Hydrophobic TM5 L 212 5x65 G.H5 I 344 G.H5.16
Hydrophobic TM6 I 230 6x37 G.H5 L 353 G.H5.25
Polar ICL2 P 129 - G.H5 N 347 G.H5.19
Polar TM2 R 60 2x40 G.H5 C 351 G.H5.23
Van-der-waals TM2 R 60 2x40 G.H5 C 351 G.H5.23
Polar TM6 R 225 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 225 6x32 G.H5 F 354 G.H5.26
Ionic TM3 R 125 3x53 G.H5 D 350 G.H5.22
Polar TM3 R 125 3x53 G.H5 D 350 G.H5.22
Van-der-waals TM3 R 125 3x53 G.H5 D 350 G.H5.22
Polar TM6 R 225 6x32 G.H5 L 353 G.H5.25
Polar TM2 S 59 2x39 G.H5 D 350 G.H5.22
Polar TM6 R 219 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 R 219 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 K 222 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 222 6x29 G.H5 F 354 G.H5.26
Polar TM6 K 222 6x29 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 K 222 6x29 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 F 229 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 K 135 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 P 129 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 129 - G.H5 I 344 G.H5.16
Polar TM3 R 125 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 R 125 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 R 125 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL3 M 217 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 M 217 - G.S6 Y 320 G.S6.02
Polar TM2 R 60 2x40 G.H5 D 350 G.H5.22
Van-der-waals TM2 R 60 2x40 G.H5 D 350 G.H5.22
Hydrophobic TM5 L 212 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM3 R 122 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 129 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 129 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 P 129 - G.H5 T 340 G.H5.12
Hydrophobic TM3 R 125 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM6 R 219 6x26 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 219 6x26 G.H5 F 354 G.H5.26
Hydrophobic ICL3 M 217 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 M 217 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 I 223 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 I 223 6x30 G.H5 F 354 G.H5.26
Hydrophobic TM6 I 223 6x30 G.H5 L 348 G.H5.20
Van-der-waals TM6 I 223 6x30 G.H5 L 348 G.H5.20
Hydrophobic TM3 V 126 3x54 G.H5 I 344 G.H5.16
Hydrophobic C-term P 296 - G.H5 F 354 G.H5.26
Van-der-waals C-term P 296 - G.H5 F 354 G.H5.26
Hydrophobic ICL3 D 218 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 D 218 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 R 219 6x26 G.H5 K 345 G.H5.17
Van-der-waals TM6 R 219 6x26 G.H5 K 345 G.H5.17