PDB
8UUJ
Resolution
2.6 Å
Released
Feb. 26, 2025
Receptor
HCA2
Class
A
Species
Mus musculus
Ligand
compound (+)17a [PMID: 20363624]
Function
Agonist
Reference
10.1016/J.CELL.2024.11.001

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Ligand Amino Acid Generic Number Segment Interaction Type
compound (+)17a [PMID: 20363624] L80 2.60x60 TM2 hydrophobic
compound (+)17a [PMID: 20363624] W88 ECL1 hydrophobic
compound (+)17a [PMID: 20363624] L101 3.29x29 TM3 hydrophobic
compound (+)17a [PMID: 20363624] L104 3.32x32 TM3 hydrophobic
compound (+)17a [PMID: 20363624] K108 3.36x36 TM3 polar (charge-assisted hydrogen bond)
compound (+)17a [PMID: 20363624] S175 45.51x51 ECL2 Van der Waals
compound (+)17a [PMID: 20363624] S176 45.52x52 ECL2 polar (hydrogen bond with backbone)
compound (+)17a [PMID: 20363624] S176 45.52x52 ECL2 polar (hydrogen bond)
compound (+)17a [PMID: 20363624] S176 45.52x52 ECL2 polar (hydrogen bond)
compound (+)17a [PMID: 20363624] F177 ECL2 Van der Waals
compound (+)17a [PMID: 20363624] F177 ECL2 aromatic (face-to-face)
compound (+)17a [PMID: 20363624] F274 7.36x35 TM7 Van der Waals
compound (+)17a [PMID: 20363624] F274 7.36x35 TM7 hydrophobic
compound (+)17a [PMID: 20363624] L277 7.39x38 TM7 hydrophobic
compound (+)17a [PMID: 20363624] Y281 7.43x42 TM7 polar (hydrogen bond)
compound (+)17a [PMID: 20363624] Y281 7.43x42 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 L K S W ICL1ECL1 W D W R F ECL1ICL2 P H H F L N K I ICL2ECL2 M M T K N G E A Y L C S S F S I C Y N F ECL2ICL3 M D R H A ICL3ECL3 N V R N C D I ECL3N-term M S K S D H F L V I N G K N C C V F R D E N-termC-term R K K T L G E P D N N R S T S V E L T G D P S T T R S I P G A L M A D P S E P G S P P Y L A S T S R C-term N I A K V L P P V L G L E F V F G L L G N G L A L W I F C F H K S S R I F L F N L A V A D F L L I I C L P F L T D N Y V H N G G I P C R V M L F M L A M N R Q G S I I F L T V V A V D R Y F R V V H S N R T A A I I S C F L W G L T I G L T V H L L Y T N R W H D A M F L L E F F L P L A I I L F C S G R I I W S L R Q R Q K I K R A I N F I M V V A I V F I I C F L P S V A V R I R I F W L L Y K Y Y S S V D L A F F T T L S F T Y M N S M L D P V V Y Y F S S P S F S T C L F P N F C I N R
Helix box plot — Download: PNG | SVG G N G L L G F V F E L G L V P P L V K A 1 F N L A V A D F L L I I C L P F L T D N 2 V T L F I I S G Q R N M A L M F L M V R 3 A A I I S C F L W G L T I G L T V H L L 4 S C F L I I A L P L F F E L L F M A D H W 5 M V V A I V F I I C F L P S V A V R I R 6 V P D L M S N M Y T F S L T T F F A L 7

GPCRdb(A)
GPCRdb(A)
HCA2 receptor
TM2
2x60 2.60x60 L80
TM3
3x29 3.29x29 L101
3x32 3.32x32 L104
3x36 3.36x36 R108
ECL2
45x51 45.51x51 S175
45x52 45.52x52 S176
TM7
7x35 7.36x35 F274
7x38 7.39x38 L277
7x42 7.43x42 Y281