D2 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8IRS

RESOLUTION

3.0 Å

REFERENCE

10.1038/S41422-023-00808-0

PUBLICATION DATE

June 7, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

56 interactions (Click to see)

LIGANDS

rotigotine - Agonist pubchem gtoplig chembl_ligand drugbank drug_central

PHYSIOLOGICAL LIGANDS

dopamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Van-der-waals TM6 M 374 6x36 G.H5 G 352 G.H5.24
Hydrophobic TM4 T 144 4x34 G.hns1 A 31 G.hns1.02
Van-der-waals TM4 T 144 4x34 G.hns1 A 31 G.hns1.02
Hydrophobic TM2 T 69 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 T 69 2x39 G.H5 C 351 G.H5.23
Polar H8 N 430 8x47 G.H5 K 349 G.H5.21
Hydrophobic TM3 R 132 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 132 3x50 G.H5 L 353 G.H5.25
Polar H8 N 430 8x47 G.H5 D 350 G.H5.22
Hydrophobic H8 N 430 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 N 430 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM5 L 216 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 216 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM4 T 144 4x34 G.hns1 R 32 G.hns1.03
Polar TM2 T 69 2x39 G.H5 D 350 G.H5.22
Hydrophobic ICL2 P 139 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 139 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 Y 142 34x53 G.H5 D 350 G.H5.22
Van-der-waals ICL2 Y 142 34x53 G.H5 D 350 G.H5.22
Hydrophobic ICL2 M 140 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 M 140 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL3 R 219 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 R 219 - G.H5 I 344 G.H5.16
Hydrophobic ICL2 N 143 34x54 G.H5 I 343 G.H5.15
Polar TM6 A 371 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 371 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 371 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 M 374 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 M 374 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 139 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 139 34x50 G.H5 I 344 G.H5.16
Polar TM3 A 135 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 135 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 135 3x53 G.H5 N 347 G.H5.19
Ionic TM6 E 368 6x30 G.H5 K 345 G.H5.17
Polar TM6 E 368 6x30 G.H5 K 345 G.H5.17
Van-der-waals TM6 E 368 6x30 G.H5 K 345 G.H5.17
Ionic ICL3 R 219 - G.H5 D 341 G.H5.13
Polar ICL3 R 219 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 R 219 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 219 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 M 140 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 M 140 34x51 G.H5 I 343 G.H5.15
Hydrophobic TM4 Y 146 4x36 G.HN R 24 G.HN.48
Van-der-waals TM4 Y 146 4x36 G.HN R 24 G.HN.48
Hydrophobic ICL2 Y 142 34x53 G.H5 C 351 G.H5.23
Polar TM3 R 132 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 132 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 132 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 K 370 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 370 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM5 I 212 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 212 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 371 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM3 A 135 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 135 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM6 E 368 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 E 368 6x30 G.H5 F 354 G.H5.26
Hydrophobic ICL2 Y 142 34x53 G.H5 N 347 G.H5.19
Van-der-waals ICL2 Y 142 34x53 G.H5 N 347 G.H5.19
Van-der-waals ICL3 R 219 - G.H5 K 345 G.H5.17
Hydrophobic ICL2 M 140 34x51 G.H5 T 340 G.H5.12
Hydrophobic TM4 Y 146 4x36 G.HN E 28 G.HN.52
Van-der-waals TM4 Y 146 4x36 G.HN E 28 G.HN.52
Hydrophobic TM3 V 136 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 136 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 375 6x37 G.H5 L 353 G.H5.25
Polar TM2 T 67 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 T 67 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 T 67 2x37 G.H5 D 350 G.H5.22
Polar ICL2 P 139 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 139 34x50 G.H5 N 347 G.H5.19