Structure information

D2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8IRS

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

R

REFERENCE

10.1038/S41422-023-00808-0

PUBLICATION DATE

June 7, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
rotigotine V91 2.61x60 TM2 polar (hydrogen bond)
rotigotine L94 2.64x63 TM2 polar (hydrogen bond)
rotigotine D114 3.32x32 TM3 polar (charge-assisted hydrogen bond)
rotigotine V115 3.33x33 TM3 Van der Waals
rotigotine V115 3.33x33 TM3 polar (hydrogen bond with backbone)
rotigotine C118 3.36x36 TM3 polar (hydrogen bond)
rotigotine T119 3.37x37 TM3 polar (hydrogen bond)
rotigotine I183 45.51x51 ECL2 polar (hydrogen bond)
rotigotine I184 45.52x52 ECL2 Van der Waals
rotigotine V190 5.39x40 TM5 Van der Waals
rotigotine S193 5.42x43 TM5 polar (hydrogen bond with backbone)
rotigotine S193 5.42x43 TM5 polar (hydrogen bond)
rotigotine S193 5.42x43 TM5 polar (hydrogen bond)
rotigotine S194 5.43x44 TM5 polar (hydrogen bond)
rotigotine S194 5.43x44 TM5 polar (hydrogen bond with backbone)
rotigotine S197 5.46x461 TM5 polar (hydrogen bond)
rotigotine W386 6.48x48 TM6 hydrophobic
rotigotine W386 6.48x48 TM6 Van der Waals
rotigotine F389 6.51x51 TM6 polar (hydrogen bond)
rotigotine F390 6.52x52 TM6 Van der Waals
rotigotine F390 6.52x52 TM6 aromatic (edge-to-face)
rotigotine H393 6.55x55 TM6 polar (hydrogen bond)
rotigotine Y408 7.35x34 TM7 polar (hydrogen bond)
rotigotine T412 7.39x38 TM7 polar (hydrogen bond)
rotigotine T412 7.39x38 TM7 polar (hydrogen bond with backbone)
rotigotine G415 7.42x41 TM7 Van der Waals
rotigotine Y416 7.43x42 TM7 polar (hydrogen bond)
rotigotine Y416 7.43x42 TM7 polar (hydrogen bond with backbone)

Ligands

rotigotine

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Residue Diagrams

V N G F V I V A I L L T L L T A Y Y N Y 1 V S L A V A D L L V A L T V M P W V V Y L 2 A C L N L I S A T C M M V D L T V F I D 3 V T V M I S I V W V L S F T I S C P L 4 Y V L L T V I F P V Y F S V I S S Y V V F 5 A I V L G V F I I C W L P F F I T H I L 6 I P N V A S N V Y G L W T F A S Y L V 7
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ICL1 K A L Q ICL1ECL1 E W K F ECL1ICL2 P M L Y N ICL2ECL2 L N N A D Q N E C I I A ECL2ICL3 R S S R A F R A H L R A P L K G N C T H P E D M K L C T V I M K S N G S F P V N R R R V E A A R R A Q E L E M E M L S S T S P P E R T R Y S P I P P S H H Q L T L P D P S H H G L H S T P D S P A K P E K N G H A K D H P K I A K I F E I Q T M P N G K T R T S L K T M S R R ICL3ECL3 D C N I ECL3N-term M D P L N L S W Y D D D L E R Q N W S R P F N G S D G K A D N-termC-term C C-term R P H Y N Y Y A T L L T L L I A V I V F G N V L V C M A V S R E T T T N Y L I V S L A V A D L L V A T L V M P W V V Y L E V V G S R I H C D I F V T L D V M M C T A S I L N L C A I S I D R Y T A V A M T R Y S S K R R V T V M I S I V W V L S F T I S C P L L F G N P A F V V Y S S I V S F Y V P F I V T L L V Y I K I Y I V L R R R R K R V N T K K L S Q Q K E K K A T Q M L A I V L G V F I I C W L P F F I T H I L N I H C P P V L Y S A F T W L G Y V N S A V N P I I Y T T F N I E F L K F R K A I L H
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Residue Table


GPCRdb(A)
GPCRdb(A)
D2 receptor
TM2
2x60 2.61x60 V91
2x63 2.64x63 L94
TM3
3x32 3.32x32 D114
3x33 3.33x33 V115
3x36 3.36x36 C118
3x37 3.37x37 T119
ECL2
45x51 45.51x51 I183
45x52 45.52x52 I184
TM5
5x40 5.39x40 V190
5x43 5.42x43 S193
5x44 5.43x44 S194
5x461 5.46x461 S197
TM6
6x48 6.48x48 W386
6x51 6.51x51 F389
6x52 6.52x52 F390
6x55 6.55x55 H393
TM7
7x34 7.35x34 Y408
7x38 7.39x38 T412
7x41 7.42x41 G415
7x42 7.43x42 Y416