SMO - Gi1

GPCR CLASS (FAMILY)

Class F (Frizzled)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

6XBL

RESOLUTION

3.9 Å

REFERENCE

10.1038/S41589-020-0646-2

PUBLICATION DATE

Sept. 30, 2020

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

39 interactions (Click to see)

LIGANDS

Cholesterol - Agonist pubchem ,

SAG1.3 - PAM pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 P 263 2x40 G.H5 C 351 G.H5.23
Hydrophobic ICL2 T 348 - G.S3 L 194 G.S3.01
Hydrophobic TM2 A 264 2x41 G.H5 G 352 G.H5.24
Polar TM2 R 261 2x38 G.H5 K 349 G.H5.21
Hydrophobic TM2 R 261 2x38 G.H5 K 349 G.H5.21
Van-der-waals TM2 R 261 2x38 G.H5 K 349 G.H5.21
Hydrophobic TM3 F 343 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM3 L 346 3x57 G.H5 L 348 G.H5.20
Van-der-waals TM3 L 346 3x57 G.H5 L 348 G.H5.20
Hydrophobic C-term W 535 - G.H5 L 353 G.H5.25
Van-der-waals C-term W 535 - G.H5 L 353 G.H5.25
Polar TM3 W 339 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 W 339 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 W 339 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM6 T 448 6x29 G.H5 L 353 G.H5.25
Hydrophobic ICL2 G 347 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 T 349 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 T 349 - G.hns1 R 32 G.hns1.03
Hydrophobic TM2 R 261 2x38 G.H5 D 350 G.H5.22
Van-der-waals TM2 R 261 2x38 G.H5 D 350 G.H5.22
Polar TM3 A 345 3x56 G.H5 N 347 G.H5.19
Hydrophobic TM3 F 343 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 F 343 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM6 R 451 6x32 G.H5 L 353 G.H5.25
Hydrophobic TM6 K 444 6x25 G.H5 F 354 G.H5.26
Hydrophobic TM3 L 346 3x57 G.H5 I 344 G.H5.16
Hydrophobic TM3 L 346 3x57 G.H5 N 347 G.H5.19
Hydrophobic TM6 A 441 6x22 G.H5 I 344 G.H5.16
Hydrophobic ICL2 G 347 - G.H5 I 344 G.H5.16
Polar ICL3 L 436 - G.H5 D 337 G.H5.09
Hydrophobic TM3 W 339 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM3 F 343 3x54 G.H5 L 353 G.H5.25
Hydrophobic ICL3 G 435 - G.H5 F 336 G.H5.08
Van-der-waals ICL3 G 435 - G.H5 F 336 G.H5.08
Hydrophobic TM6 S 438 6x19 G.H5 D 341 G.H5.13
Hydrophobic ICL3 L 437 - G.H5 I 344 G.H5.16
Hydrophobic ICL2 T 349 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 T 349 - G.S1 V 34 G.S1.02
Van-der-waals ICL2 T 349 - G.S1 V 34 G.S1.02
Hydrophobic ICL2 Y 350 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Y 350 - G.hns1 R 32 G.hns1.03
Polar TM5 H 433 5x76 G.H5 T 340 G.H5.12
Van-der-waals TM5 H 433 5x76 G.H5 T 340 G.H5.12
Van-der-waals ICL3 G 435 - G.H5 D 337 G.H5.09