H4 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.1 Å

REFERENCE

PUBLICATION DATE

Oct. 25, 2023

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

PHYSIOLOGICAL LIGANDS

CCL16, histamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Polar ICL2 A 119 34x50 G.H5 N 354 G.H5.19
Van-der-waals ICL2 A 119 34x50 G.H5 N 354 G.H5.19
Hydrophobic ICL2 R 123 34x54 G.H5 I 350 G.H5.15
Van-der-waals ICL2 R 123 34x54 G.H5 I 350 G.H5.15
Polar TM2 S 50 2x39 G.H5 Y 358 G.H5.23
Hydrophobic TM2 S 50 2x39 G.H5 Y 358 G.H5.23
Van-der-waals TM2 S 50 2x39 G.H5 Y 358 G.H5.23
Polar TM3 D 111 3x49 G.H5 Y 358 G.H5.23
Van-der-waals TM3 D 111 3x49 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 T 124 34x55 G.S1 L 34 G.S1.02
Van-der-waals ICL2 T 124 34x55 G.S1 L 34 G.S1.02
Hydrophobic TM3 V 116 3x54 G.H5 L 360 G.H5.25
Ionic H8 H 362 8x47 G.H5 E 357 G.H5.22
Polar H8 H 362 8x47 G.H5 E 357 G.H5.22
Hydrophobic H8 H 362 8x47 G.H5 E 357 G.H5.22
Van-der-waals H8 H 362 8x47 G.H5 E 357 G.H5.22
Aromatic ICL2 H 126 - G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 T 127 - G.HN Q 28 G.HN.52
Hydrophobic TM6 L 301 6x33 G.H5 L 360 G.H5.25
Van-der-waals TM6 L 301 6x33 G.H5 L 360 G.H5.25
Hydrophobic ICL2 V 120 34x51 G.H5 I 350 G.H5.15
Hydrophobic TM2 F 54 2x43 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 T 124 34x55 G.hns1 R 31 G.hns1.02
Hydrophobic TM5 L 201 5x65 G.H5 L 355 G.H5.20
Hydrophobic ICL2 A 119 34x50 G.H5 L 351 G.H5.16
Van-der-waals ICL2 A 119 34x50 G.H5 L 351 G.H5.16
Hydrophobic ICL2 R 123 34x54 G.H5 M 353 G.H5.18
Ionic ICL2 R 123 34x54 G.H5 E 357 G.H5.22
Polar ICL2 R 123 34x54 G.H5 E 357 G.H5.22
Hydrophobic TM3 S 115 3x53 G.H5 Y 358 G.H5.23
Ionic H8 R 364 8x49 G.H5 E 357 G.H5.22
Hydrophobic ICL2 V 120 34x51 G.H5 K 347 G.H5.12
Van-der-waals ICL2 V 120 34x51 G.H5 K 347 G.H5.12
Hydrophobic TM5 I 197 5x61 G.H5 L 360 G.H5.25
Polar H8 K 363 8x48 G.H5 E 357 G.H5.22
Hydrophobic H8 K 363 8x48 G.H5 E 357 G.H5.22
Van-der-waals H8 K 363 8x48 G.H5 E 357 G.H5.22
Polar ICL4 C 361 - G.H5 N 359 G.H5.24
Hydrophobic ICL4 C 361 - G.H5 N 359 G.H5.24
Van-der-waals ICL4 C 361 - G.H5 N 359 G.H5.24
Hydrophobic TM6 L 301 6x33 G.H5 V 361 G.H5.26
Aromatic TM3 R 112 3x50 G.H5 Y 358 G.H5.23
Hydrophobic TM3 R 112 3x50 G.H5 Y 358 G.H5.23
Van-der-waals TM3 R 112 3x50 G.H5 Y 358 G.H5.23
Hydrophobic ICL2 Y 122 34x53 G.H5 N 354 G.H5.19
Hydrophobic ICL2 A 119 34x50 G.H5 I 350 G.H5.15
Van-der-waals ICL2 A 119 34x50 G.H5 I 350 G.H5.15
Polar ICL2 R 123 34x54 G.H5 N 354 G.H5.19
Hydrophobic ICL2 R 123 34x54 G.H5 N 354 G.H5.19
Van-der-waals ICL2 R 123 34x54 G.H5 N 354 G.H5.19
Ionic TM2 H 48 2x37 G.H5 E 357 G.H5.22
Hydrophobic ICL2 T 124 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 T 124 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 V 116 3x54 G.H5 L 351 G.H5.16
Hydrophobic ICL2 Q 125 34x56 G.S3 V 194 G.S3.01
Aromatic H8 H 362 8x47 G.H5 Y 358 G.H5.23
Hydrophobic H8 H 362 8x47 G.H5 Y 358 G.H5.23
Van-der-waals H8 H 362 8x47 G.H5 Y 358 G.H5.23
Polar TM3 S 115 3x53 G.H5 N 354 G.H5.19
Hydrophobic TM3 S 115 3x53 G.H5 N 354 G.H5.19
Van-der-waals TM3 S 115 3x53 G.H5 N 354 G.H5.19
Polar ICL2 Q 125 34x56 G.s2s3 K 193 G.s2s3.02
Polar H8 Q 366 8x51 G.H5 N 359 G.H5.24
Van-der-waals H8 Q 366 8x51 G.H5 N 359 G.H5.24
Polar ICL2 T 127 - G.hns1 R 31 G.hns1.02
Hydrophobic TM3 V 116 3x54 G.H5 L 355 G.H5.20