Structure information

H4 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7YFD

SPECIES

Homo sapiens

RESOLUTION

3.100

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-023-42260-Z

PUBLICATION DATE

Oct. 25, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
imetit D94 3.32x32 TM3 polar (charge-assisted hydrogen bond)
imetit Y95 3.33x33 TM3 hydrophobic
imetit Y95 3.33x33 TM3 Van der Waals
imetit C98 3.36x36 TM3 hydrophobic
imetit C98 3.36x36 TM3 Van der Waals
imetit T99 3.37x37 TM3 Van der Waals
imetit E182 5.46x461 TM5 polar (charge-assisted hydrogen bond)
imetit W316 6.48x48 TM6 hydrophobic
imetit W316 6.48x48 TM6 Van der Waals
imetit Y319 6.51x51 TM6 Van der Waals
imetit F344 7.39x38 TM7 polar (hydrogen bond with backbone)
imetit F344 7.39x38 TM7 Van der Waals
imetit Q347 7.42x41 TM7 Van der Waals
imetit W348 7.43x42 TM7 polar (hydrogen bond)

Ligands

imetit

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Residue Diagrams

A N G L M I A F A V L S M F F A L T V R 1 L N L A I S D F F V G I V S I P L Y I P H 2 L V I N Y V S A T C L L Y D T T L W F V 3 I V T L M V A V W V L A F L V N G P M 4 N F Y A V L I V P I V F E L F S T I A L I 5 A I L L G V F A V C W A P Y S L F T I V 6 L P N V F S N F W Q L W F A I R Y W V 7
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ICL1 K N L R ICL1ECL1 F E W D F ECL1ICL2 A V S Y R T Q H T ICL2ECL2 D E G S E C E P G F F S ECL2ICL3 H P G L T A V S S N I C G H S F R G R L S S R R S L S A S T E V P A S F H S E R Q R R K S S L M F S S R T K M N S N T I A S K M G S F S Q S D S V A L H Q R E ICL3ECL3 S S A T G P K ECL3N-term M P D T N S T I N L N-termC-term K K Q P L P S Q H S R S V S S C-term S L S T R V T L A F F M S L V A F A I M L G N A L V I L A F V V D H R S S Y F F L N L A I S D F F V G V I S I P L Y I P H T L G K E I C V F W L T T D Y L L C T A S V Y N I V L I S Y D R Y L S V S N G V L K I V T L M V A V W V L A F L V N G P M I L V S E S W K E W Y I L A I T S F L E F V I P V I L V A Y F N M N I Y W S L W K R D H L S R C Q S H V E L L R A R R L A K S L A I L L G V F A V C W A P Y S L F T I V L S F Y S V W Y R I A F W L Q W F N S F V N P L L Y P L C H K R F L K F Q K A I F C I
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Residue Table


GPCRdb(A)
GPCRdb(A)
H4 receptor
TM3
3x32 3.32x32 D94
3x33 3.33x33 Y95
3x36 3.36x36 C98
3x37 3.37x37 T99
TM5
5x461 5.46x461 E182
TM6
6x48 6.48x48 W316
6x51 6.51x51 Y319
TM7
7x38 7.39x38 F344
7x41 7.42x41 Q347
7x42 7.43x42 W348