GPCRdb

xylometazoline

Agent/drug
Bioactivity

xylometazoline

SMILES	Cc1cc(C(C)(C)C)cc(C)c1CC1=NCCN1
InChIKey	HUCJFAOMUPXHDK-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	1
Rotatable bonds	2
Molecular weight (Da)	244.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	7.04	7.04	7.04	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.15	8.15	8.15	Drug Central
α_1D	ADA1D	Rat	Adrenoceptors	A	pKi	6.00	6.00	6.00	Guide to Pharmacology
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	7.60	7.60	7.60	Guide to Pharmacology
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	7.82	7.82	7.82	PDSP Ki database
α_2A	ADA2A	Mouse	Adrenoceptors	A	pKi	7.59	7.61	7.62	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.11	8.11	8.11	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	5.40	5.40	5.40	Guide to Pharmacology
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	5.98	5.98	5.98	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.22	8.22	8.22	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	7.00	7.00	7.00	Guide to Pharmacology
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.89	6.89	6.89	PDSP Ki database
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.16	8.16	8.16	Drug Central
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	7.85	7.87	7.89	ChEMBL
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	8.10	8.10	8.10	Drug Central
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	9.15	9.15	9.15	ChEMBL
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	8.04	8.04	8.04	Drug Central

Showing 1 to 17 of 17 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	8.10	8.10	8.10	Guide to Pharmacology
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	8.80	8.80	8.80	Guide to Pharmacology
α_2B	ADA2B	Human	Adrenoceptors	A	pEC50	7.80	7.80	7.80	Guide to Pharmacology
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	7.20	7.20	7.20	Guide to Pharmacology
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pEC50	6.89	6.89	6.89	ChEMBL
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pEC50	6.43	6.43	6.43	ChEMBL
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	5.00	5.12	5.25	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	4.80	5.10	5.40	ChEMBL

Showing 1 to 8 of 8 entries

xylometazoline

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 6

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Acute nasopharyngitis	CA00	S01G, R01A	0.322	3	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Allergic conjunctivitis	9A60.02	S01G, R01A	0.540	4	Yes
ADA1A	α_1A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Nasal congestion	MD11.9	S01G, R01A	0.607	4	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Acute nasopharyngitis	CA00	S01G, R01A	0.322	3	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Allergic conjunctivitis	9A60.02	S01G, R01A	0.540	4	Yes
ADA1B	α_1B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Nasal congestion	MD11.9	S01G, R01A	0.607	4	Yes
ADA1D	α_1D-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Acute nasopharyngitis	CA00	S01G, R01A	0.322	3	Yes
ADA1D	α_1D-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Allergic conjunctivitis	9A60.02	S01G, R01A	0.540	4	Yes
ADA1D	α_1D-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Nasal congestion	MD11.9	S01G, R01A	0.607	4	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Acute nasopharyngitis	CA00	S01G, R01A	0.596	3	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Allergic conjunctivitis	9A60.02	S01G, R01A	0.551	4	Yes
ADA2A	α_2A-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Nasal congestion	MD11.9	S01G, R01A	0.601	4	Yes
ADA2B	α_2B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Acute nasopharyngitis	CA00	S01G, R01A	0.596	3	Yes
ADA2B	α_2B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Allergic conjunctivitis	9A60.02	S01G, R01A	0.551	4	Yes
ADA2B	α_2B-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Nasal congestion	MD11.9	S01G, R01A	0.601	4	Yes
ADA2C	α_2C-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Acute nasopharyngitis	CA00	S01G, R01A	0.596	3	Yes
ADA2C	α_2C-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Allergic conjunctivitis	9A60.02	S01G, R01A	0.551	4	Yes
ADA2C	α_2C-adrenoceptor	Adrenoceptors	Aminergic receptors	Class A	Nasal congestion	MD11.9	S01G, R01A	0.601	4	Yes

Showing 1 to 18 of 18 entries

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xylometazoline

xylometazoline

Chemical Properties

Database connections

Bioactivities

xylometazoline

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information