H4 receptor (hrh4_human)
FAMILY
Class A (Rhodopsin) Aminergic receptors Histamine receptors H4 receptor
GENE
HRH4 (GPCR105)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Histamine H4 receptor, H4R, HH4R, AXOR35, G-protein coupled receptor 105, GPRv53, Pfi-013, SP9144
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
P
|
D
|
T
|
N
|
S
|
T
|
I
|
N
|
L
|
10 |
TM1 | |||||||||
S
|
L
|
S
|
T
|
R
|
V
|
T
|
L
|
A
|
F
|
20 |
F
|
M
|
S
|
L
|
V
|
A
|
F
|
A
|
I
|
M
|
30 |
L
|
G
|
N
|
A
|
L
|
V
|
I
|
L
|
A
|
F
|
40 |
ICL1 | TM2 | ||||||||
V
|
V
|
D
|
K
|
N
|
L
|
R
|
H
|
R
|
S
|
50 |
S
|
Y
|
F
|
F
|
L
|
N
|
L
|
A
|
I
|
S
|
60 |
D
|
F
|
F
|
V
|
G
|
V
|
I
|
S
|
I
|
P
|
70 |
L
|
Y
|
I
|
P
|
H
|
T
|
L
|
F
|
E
|
W
|
80 |
ECL1 | TM3 | ||||||||
D
|
F
|
G
|
K
|
E
|
I
|
C
|
V
|
F
|
W
|
90 |
L
|
T
|
T
|
D
|
Y
|
L
|
L
|
C
|
T
|
A
|
100 |
S
|
V
|
Y
|
N
|
I
|
V
|
L
|
I
|
S
|
Y
|
110 |
D
|
R
|
Y
|
L
|
S
|
V
|
S
|
N
|
A
|
V
|
120 |
ICL2 | TM4 | ||||||||
S
|
Y
|
R
|
T
|
Q
|
H
|
T
|
G
|
V
|
L
|
130 |
K
|
I
|
V
|
T
|
L
|
M
|
V
|
A
|
V
|
W
|
140 |
V
|
L
|
A
|
F
|
L
|
V
|
N
|
G
|
P
|
M
|
150 |
I
|
L
|
V
|
S
|
E
|
S
|
W
|
K
|
D
|
E
|
160 |
ECL2 | |||||||||
G
|
S
|
E
|
C
|
E
|
P
|
G
|
F
|
F
|
S
|
170 |
TM5 | |||||||||
E
|
W
|
Y
|
I
|
L
|
A
|
I
|
T
|
S
|
F
|
180 |
L
|
E
|
F
|
V
|
I
|
P
|
V
|
I
|
L
|
V
|
190 |
A
|
Y
|
F
|
N
|
M
|
N
|
I
|
Y
|
W
|
S
|
200 |
L
|
W
|
K
|
R
|
D
|
H
|
L
|
S
|
R
|
C
|
210 |
ICL3 | |||||||||
Q
|
S
|
H
|
P
|
G
|
L
|
T
|
A
|
V
|
S
|
220 |
S
|
N
|
I
|
C
|
G
|
H
|
S
|
F
|
R
|
G
|
230 |
R
|
L
|
S
|
S
|
R
|
R
|
S
|
L
|
S
|
A
|
240 |
S
|
T
|
E
|
V
|
P
|
A
|
S
|
F
|
H
|
S
|
250 |
E
|
R
|
Q
|
R
|
R
|
K
|
S
|
S
|
L
|
M
|
260 |
F
|
S
|
S
|
R
|
T
|
K
|
M
|
N
|
S
|
N
|
270 |
T
|
I
|
A
|
S
|
K
|
M
|
G
|
S
|
F
|
S
|
280 |
Q
|
S
|
D
|
S
|
V
|
A
|
L
|
H
|
Q
|
R
|
290 |
TM6 | |||||||||
E
|
H
|
V
|
E
|
L
|
L
|
R
|
A
|
R
|
R
|
300 |
L
|
A
|
K
|
S
|
L
|
A
|
I
|
L
|
L
|
G
|
310 |
V
|
F
|
A
|
V
|
C
|
W
|
A
|
P
|
Y
|
S
|
320 |
L
|
F
|
T
|
I
|
V
|
L
|
S
|
F
|
Y
|
S
|
330 |
ECL3 | TM7 | ||||||||
S
|
A
|
T
|
G
|
P
|
K
|
S
|
V
|
W
|
Y
|
340 |
R
|
I
|
A
|
F
|
W
|
L
|
Q
|
W
|
F
|
N
|
350 |
S
|
F
|
V
|
N
|
P
|
L
|
L
|
Y
|
P
|
L
|
360 |
H8 | |||||||||
C
|
H
|
K
|
R
|
F
|
Q
|
K
|
A
|
F
|
L
|
370 |
K
|
I
|
F
|
C
|
I
|
K
|
K
|
Q
|
P
|
L
|
380 |
C-term | |||||||||
P
|
S
|
Q
|
H
|
S
|
R
|
S
|
V
|
S
|
S
|
390 |
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
CCL16, histamine