5-HT2C receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8DPF

RESOLUTION

2.8 Å

REFERENCE

10.1016/J.CELREP.2022.111211

PUBLICATION DATE

Aug. 24, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

26 interactions (Click to see)

LIGANDS

lorcaserin - Agonist pubchem gtoplig chembl_ligand drugbank drug_central

PHYSIOLOGICAL LIGANDS

5-hydroxytryptamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 R 164 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 R 164 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 164 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 I 160 34x51 G.S3 V 79 G.S3.01
Hydrophobic ICL2 I 160 34x51 G.H5 F 228 G.H5.08
Polar ICL2 P 159 34x50 G.H5 N 239 G.H5.19
Van-der-waals ICL2 P 159 34x50 G.H5 N 239 G.H5.19
Polar TM6 Q 301 6x25 G.h4s6 G 207 G.h4s6.11
Hydrophobic TM6 Q 301 6x25 G.h4s6 G 207 G.h4s6.11
Van-der-waals TM6 Q 301 6x25 G.h4s6 G 207 G.h4s6.11
Polar TM3 A 155 3x53 G.H5 N 239 G.H5.19
Hydrophobic TM2 T 88 2x39 G.H5 Y 243 G.H5.23
Hydrophobic TM6 L 313 6x37 G.H5 L 245 G.H5.25
Polar TM5 Q 244 5x68 G.H5 K 232 G.H5.12
Polar TM7 Y 368 7x53 G.H5 N 244 G.H5.24
Hydrophobic TM6 N 305 6x29 G.H5 V 246 G.H5.26
Hydrophobic TM6 V 312 6x36 G.H5 L 245 G.H5.25
Hydrophobic TM3 A 155 3x53 G.H5 Y 243 G.H5.23
Van-der-waals TM3 A 155 3x53 G.H5 Y 243 G.H5.23
Hydrophobic TM3 I 156 3x54 G.H5 L 236 G.H5.16
Polar TM3 D 151 3x49 G.H5 Y 243 G.H5.23
Hydrophobic TM3 D 151 3x49 G.H5 Y 243 G.H5.23
Van-der-waals TM3 D 151 3x49 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 P 159 34x50 G.H5 L 236 G.H5.16
Polar H8 N 372 8x47 G.H5 N 244 G.H5.24
Hydrophobic H8 N 372 8x47 G.H5 N 244 G.H5.24
Van-der-waals H8 N 372 8x47 G.H5 N 244 G.H5.24
Hydrophobic H8 Y 375 8x50 G.H5 N 244 G.H5.24
Hydrophobic TM5 Q 244 5x68 G.H5 L 236 G.H5.16
Hydrophobic TM6 K 308 6x32 G.H5 V 246 G.H5.26
Van-der-waals TM6 K 308 6x32 G.H5 V 246 G.H5.26
Hydrophobic TM6 A 309 6x33 G.H5 L 245 G.H5.25
Hydrophobic ICL2 I 160 34x51 G.H5 I 235 G.H5.15
Hydrophobic TM3 R 152 3x50 G.H5 L 245 G.H5.25
Hydrophobic TM6 E 306 6x30 G.H5 L 240 G.H5.20
Hydrophobic TM6 A 302 6x26 G.h4s6 I 210 G.h4s6.20
Polar TM3 R 152 3x50 G.H5 Y 243 G.H5.23
Hydrophobic TM3 R 152 3x50 G.H5 Y 243 G.H5.23
Van-der-waals TM3 R 152 3x50 G.H5 Y 243 G.H5.23
Polar TM2 T 88 2x39 G.H5 E 242 G.H5.22
Hydrophobic ICL2 P 159 34x50 G.H5 I 235 G.H5.15
Van-der-waals ICL2 P 159 34x50 G.H5 I 235 G.H5.15
Polar TM6 N 305 6x29 G.H5 Q 237 G.H5.17
Van-der-waals TM6 N 305 6x29 G.H5 Q 237 G.H5.17
Polar ICL2 H 162 34x53 G.H5 Y 243 G.H5.23
Van-der-waals ICL2 H 162 34x53 G.H5 Y 243 G.H5.23
Polar TM6 A 302 6x26 G.H5 Q 237 G.H5.17
Hydrophobic ICL2 P 159 34x50 G.H5 K 232 G.H5.12
Hydrophobic TM3 I 156 3x54 G.H5 L 240 G.H5.20
Hydrophobic TM6 Q 301 6x25 G.h4s6 I 210 G.h4s6.20