NTS1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9VB7

RESOLUTION

3.0 Å

REFERENCE

10.1038/S41586-026-10228-W

PUBLICATION DATE

June 3, 2026

3D VIEW

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LIGAND INTERACTIONS

52 interactions (Click to see)

LIGANDS

JMV449 - Agonist pubchem gtoplig

PHYSIOLOGICAL LIGANDS

large neuromedin N (Mouse), neurotensin (Human), neuromedin N (Human), large neuromedin N (Human), large neuromedin N (Rat), large neurotensin (Human), neuromedin N (Mouse)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL1 S 99 - G.H5 D 350 G.H5.22
Hydrophobic ICL3 G 293 - G.H5 K 349 G.H5.21
Hydrophobic TM3 I 170 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 I 170 3x54 G.H5 L 353 G.H5.25
Hydrophobic ICL3 S 287 - G.S6 F 323 G.S6.05
Hydrophobic ICL2 P 173 - G.H5 L 348 G.H5.20
Polar ICL2 T 178 - G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 T 178 - G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 T 178 - G.s2s3 D 193 G.s2s3.02
Polar ICL3 S 287 - G.H4 Q 304 G.H4.12
Hydrophobic ICL3 S 287 - G.H4 Q 304 G.H4.12
Van-der-waals ICL3 S 287 - G.H4 Q 304 G.H4.12
Hydrophobic ICL2 F 174 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 F 174 - G.H5 T 340 G.H5.12
Polar ICL2 T 178 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 T 178 - G.hns1 R 32 G.hns1.03
Hydrophobic H8 S 368 8x47 G.H5 L 353 G.H5.25
Hydrophobic ICL3 F 286 - G.S6 F 323 G.S6.05
Hydrophobic ICL2 F 174 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 F 174 - G.H5 I 344 G.H5.16
Hydrophobic ICL3 A 289 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL1 L 97 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL1 L 97 - G.hns1 A 31 G.hns1.02
Polar ICL3 E 291 - G.S6 Y 320 G.S6.02
Hydrophobic ICL2 P 173 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 173 - G.H5 I 344 G.H5.16
Hydrophobic ICL3 F 286 - G.H5 F 334 G.H5.06
Polar ICL3 S 287 - G.S6 T 321 G.S6.03
Hydrophobic ICL3 S 287 - G.S6 T 321 G.S6.03
Van-der-waals ICL3 S 287 - G.S6 T 321 G.S6.03
Hydrophobic ICL2 P 173 - G.H5 K 345 G.H5.17
Hydrophobic TM3 R 166 3x50 G.H5 C 351 G.H5.23
Polar ICL3 E 291 - G.H5 N 346 G.H5.18
Hydrophobic ICL1 L 94 - G.h2s4 E 216 G.h2s4.02
Hydrophobic TM6 G 301 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 G 301 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 298 6x30 G.H5 K 349 G.H5.21
Polar H8 S 368 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 S 368 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 S 368 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM2 L 105 2x43 G.H5 G 352 G.H5.24
Polar ICL2 M 180 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 M 180 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 M 180 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 F 286 - G.S6 H 322 G.S6.04
Polar ICL3 M 288 - G.S6 T 321 G.S6.03
Hydrophobic ICL3 M 288 - G.S6 T 321 G.S6.03
Van-der-waals ICL3 M 288 - G.S6 T 321 G.S6.03
Hydrophobic ICL3 I 290 - G.H5 V 342 G.H5.14
Hydrophobic TM3 I 170 3x54 G.H5 F 354 G.H5.26
Hydrophobic ICL3 I 290 - G.H5 D 341 G.H5.13
Hydrophobic TM6 L 298 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 L 298 6x30 G.H5 F 354 G.H5.26
Polar TM4 S 181 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 S 181 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 S 181 4x38 G.HN E 28 G.HN.52
Hydrophobic ICL3 M 288 - G.S6 H 322 G.S6.04
Van-der-waals ICL3 M 288 - G.S6 H 322 G.S6.04
Hydrophobic TM3 R 166 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 305 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 305 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 263 5x65 G.H5 F 354 G.H5.26
Van-der-waals TM5 L 263 5x65 G.H5 F 354 G.H5.26
Hydrophobic TM6 V 304 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 304 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM2 V 101 2x39 G.H5 C 351 G.H5.23
Polar ICL1 Q 98 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL1 Q 98 - G.hns1 A 31 G.hns1.02
Hydrophobic TM3 I 170 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 170 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 F 174 - G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 F 174 - G.s2s3 K 192 G.s2s3.01
Hydrophobic ICL2 M 180 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL3 A 289 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 E 291 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 A 297 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 A 297 6x29 G.H5 K 349 G.H5.21
Van-der-waals TM6 A 297 6x29 G.H5 K 349 G.H5.21
Hydrophobic ICL2 K 177 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 K 177 - G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 F 174 - G.S3 L 194 G.S3.01
Polar TM4 S 181 4x38 G.hns1 R 32 G.hns1.03
Hydrophobic TM4 S 181 4x38 G.hns1 R 32 G.hns1.03
Polar TM4 S 183 4x40 G.HN E 28 G.HN.52
Hydrophobic TM4 S 183 4x40 G.HN E 28 G.HN.52
Van-der-waals TM4 S 183 4x40 G.HN E 28 G.HN.52
Hydrophobic TM5 M 266 5x68 G.H5 L 348 G.H5.20