TAS2R16 - Ggust

GPCR CLASS (FAMILY)

Class T2 (Taste 2)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9KPE

RESOLUTION

3.4 Å

REFERENCE

10.1016/J.CELREP.2025.115604

PUBLICATION DATE

April 2, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

26 interactions (Click to see)

LIGANDS

salicin - Agonist pubchem gtoplig

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 116 - G.hns1 R 32 G.hns1.03
Polar TM3 V 107 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM3 V 107 3x54 G.H5 N 347 G.H5.19
Hydrophobic TM3 V 107 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 107 3x54 G.H5 L 348 G.H5.20
Polar ICL2 R 119 - G.H5 N 347 G.H5.19
Hydrophobic TM3 K 106 3x53 G.H5 C 351 G.H5.23
Polar TM3 Y 103 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 Y 103 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 Y 103 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 107 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 V 107 3x54 G.H5 C 351 G.H5.23
Polar ICL2 T 111 - G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 T 111 - G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 W 120 - G.HN E 28 G.HN.52
Van-der-waals ICL2 W 120 - G.HN E 28 G.HN.52
Polar TM3 K 106 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 K 106 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 K 106 3x53 G.H5 N 347 G.H5.19
Polar ICL3 H 214 - G.S6 I 319 G.S6.01
Polar TM6 S 218 6x27 G.S6 Y 320 G.S6.02
Hydrophobic TM6 R 222 6x31 G.H5 L 348 G.H5.20
Polar TM6 A 225 6x34 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 225 6x34 G.H5 L 353 G.H5.25
Van-der-waals TM6 A 225 6x34 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 221 6x30 G.H5 L 348 G.H5.20
Polar TM7 S 279 7x56 G.H5 C 351 G.H5.23
Polar TM6 T 224 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 224 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 A 225 6x34 G.H5 L 348 G.H5.20
Van-der-waals TM6 A 225 6x34 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 229 6x38 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 203 5x65 G.H5 L 348 G.H5.20
Polar TM6 T 224 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 T 224 6x33 G.H5 F 354 G.H5.26
Hydrophobic ICL3 H 214 - G.H5 F 334 G.H5.06
Hydrophobic TM6 S 228 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM6 R 222 6x31 G.H5 I 344 G.H5.16
Hydrophobic TM2 M 43 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM5 H 210 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM6 A 221 6x30 G.H5 K 345 G.H5.17
Van-der-waals TM6 A 221 6x30 G.H5 K 345 G.H5.17
Polar ICL3 H 214 - G.S6 T 321 G.S6.03
Hydrophobic ICL3 H 214 - G.S6 T 321 G.S6.03
Van-der-waals ICL3 H 214 - G.S6 T 321 G.S6.03
Polar TM6 S 218 6x27 G.H5 D 341 G.H5.13
Hydrophobic TM6 S 218 6x27 G.H5 D 341 G.H5.13
Van-der-waals TM6 S 218 6x27 G.H5 D 341 G.H5.13
Hydrophobic TM5 Q 206 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 Q 206 5x68 G.H5 I 344 G.H5.16
Polar ICL3 N 216 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 N 216 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 N 216 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 W 120 - G.HN R 24 G.HN.48
Van-der-waals ICL2 W 120 - G.HN R 24 G.HN.48
Hydrophobic TM6 P 217 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 P 217 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 P 217 6x26 G.h4s6 K 317 G.h4s6.11
Hydrophobic H8 P 281 8x48 G.H5 G 352 G.H5.24
Polar TM6 P 217 6x26 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM6 P 217 6x26 G.h4s6 K 314 G.h4s6.08
Van-der-waals TM6 P 217 6x26 G.h4s6 K 314 G.h4s6.08
Polar TM7 S 279 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM7 S 279 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 S 279 7x56 G.H5 G 352 G.H5.24
Aromatic ICL3 H 214 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 H 214 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 H 214 - G.S6 Y 320 G.S6.02
Ionic TM6 R 222 6x31 G.H5 D 341 G.H5.13
Polar TM6 R 222 6x31 G.H5 D 341 G.H5.13
Hydrophobic TM6 R 222 6x31 G.H5 D 341 G.H5.13
Van-der-waals TM6 R 222 6x31 G.H5 D 341 G.H5.13
Hydrophobic TM4 R 124 4x40 G.HN R 24 G.HN.48
Van-der-waals TM4 R 124 4x40 G.HN R 24 G.HN.48
Hydrophobic H8 P 281 8x48 G.H5 D 350 G.H5.22
Van-der-waals H8 P 281 8x48 G.H5 D 350 G.H5.22
Hydrophobic ICL2 W 120 - G.HN G 27 G.HN.51
Van-der-waals ICL2 W 120 - G.HN G 27 G.HN.51
Van-der-waals TM2 V 45 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM3 Y 103 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 Y 103 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL3 G 213 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 G 213 - G.S6 Y 320 G.S6.02
Hydrophobic TM6 P 217 6x26 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 P 217 6x26 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 A 221 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 221 6x30 G.H5 F 354 G.H5.26