Rhodopsin - Gt1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Bos taurus

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Bos taurus

PDB CODE

RESOLUTION

3.2 Å

REFERENCE

PUBLICATION DATE

Dec. 13, 2017

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

B-Octylglucoside - unknown pubchem

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM3 R 135 3x50 G.H5 L 349 G.H5.25
Hydrophobic TM3 V 138 3x53 G.H5 N 343 G.H5.19
Hydrophobic TM6 T 242 6x25 G.H5 F 350 G.H5.26
Polar TM3 K 141 3x56 G.H5 N 343 G.H5.19
Hydrophobic TM3 K 141 3x56 G.H5 N 343 G.H5.19
Van-der-waals TM3 K 141 3x56 G.H5 N 343 G.H5.19
Hydrophobic TM6 V 250 6x33 G.H5 F 350 G.H5.26
Hydrophobic TM6 E 249 6x32 G.H5 F 350 G.H5.26
Hydrophobic TM6 A 246 6x29 G.H5 L 344 G.H5.20
Hydrophobic TM6 T 243 6x26 G.H5 L 341 G.H5.17
Hydrophobic TM6 M 253 6x36 G.H5 L 349 G.H5.25
Hydrophobic TM5 A 233 5x68 G.H5 I 340 G.H5.16
Van-der-waals TM5 A 233 5x68 G.H5 I 340 G.H5.16
Hydrophobic ICL1 L 72 - G.H5 D 346 G.H5.22
Van-der-waals ICL1 L 72 - G.H5 D 346 G.H5.22
Hydrophobic TM5 V 230 5x65 G.H5 L 344 G.H5.20
Hydrophobic TM6 M 257 6x40 G.H5 L 349 G.H5.25
Hydrophobic TM3 V 139 3x54 G.H5 L 344 G.H5.20
Van-der-waals TM3 V 139 3x54 G.H5 L 344 G.H5.20
Hydrophobic TM5 V 230 5x65 G.H5 I 340 G.H5.16
Hydrophobic TM5 T 229 5x64 G.H5 I 340 G.H5.16
Hydrophobic TM6 T 242 6x25 G.H5 L 341 G.H5.17
Van-der-waals TM6 T 242 6x25 G.H5 L 341 G.H5.17
Hydrophobic TM6 A 246 6x29 G.H5 L 341 G.H5.17
Van-der-waals TM6 A 246 6x29 G.H5 L 341 G.H5.17
Hydrophobic TM3 V 138 3x53 G.H5 V 347 G.H5.23
Hydrophobic TM6 V 250 6x33 G.H5 L 349 G.H5.25
Hydrophobic TM6 A 246 6x29 G.H5 F 350 G.H5.26
Van-der-waals TM6 A 246 6x29 G.H5 F 350 G.H5.26
Hydrophobic TM6 K 245 6x28 G.H5 F 350 G.H5.26
Hydrophobic TM5 L 226 5x61 G.H5 L 349 G.H5.25
Hydrophobic TM3 V 139 3x54 G.H5 N 343 G.H5.19
Hydrophobic TM6 V 250 6x33 G.H5 L 344 G.H5.20
Hydrophobic H8 N 310 8x47 G.H5 G 348 G.H5.24
Polar TM3 R 135 3x50 G.H5 V 347 G.H5.23
Hydrophobic TM3 R 135 3x50 G.H5 V 347 G.H5.23
Van-der-waals TM3 R 135 3x50 G.H5 V 347 G.H5.23