GPR119 - Gs

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gs

G PROTEIN SPECIES

Homo sapiens

PDB CODE

7XZ5

RESOLUTION

3.1 Å

REFERENCE

10.1038/S41594-022-00816-5

PUBLICATION DATE

Aug. 24, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

79 interactions (Click to see)

LIGANDS

(4R,7R,18E)-4,7-dihydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide - Agonist pubchem

ENDOGENOUS LIGANDS

N-oleoylethanolamide, SEA, anandamide, N-palmitoylethanolamine



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

GPCR AA GPCR number GPCRdb# Segment G protein AA G protein number CGN# Interaction Type
M 202 5x76 TM5 P 361 G.S6.03 hydrophobic
M 202 5x76 TM5 P 361 G.S6.03 van-der-waals
E 203 5x77 TM5 T 350 G.h4s6.03 hydrophobic
E 203 5x77 TM5 T 350 G.h4s6.03 van-der-waals
A 106 3x53 TM3 Y 391 G.H5.23 van-der-waals
G 206 5x80 TM5 R 347 G.H4.17 hydrophobic
F 111 34x51 ICL2 I 383 G.H5.15 hydrophobic
F 111 34x51 ICL2 I 383 G.H5.15 van-der-waals
F 111 34x51 ICL2 R 380 G.H5.12 hydrophobic
F 111 34x51 ICL2 R 380 G.H5.12 van-der-waals
I 107 3x54 TM3 Y 391 G.H5.23 hydrophobic
I 107 3x54 TM3 Y 391 G.H5.23 van-der-waals
K 222 6x32 TM6 E 392 G.H5.24 ionic
K 222 6x32 TM6 E 392 G.H5.24 polar
K 222 6x32 TM6 E 392 G.H5.24 van-der-waals
A 192 5x66 TM5 L 388 G.H5.20 hydrophobic
A 192 5x66 TM5 L 388 G.H5.20 van-der-waals
A 192 5x66 TM5 L 394 G.H5.26 hydrophobic
A 192 5x66 TM5 L 394 G.H5.26 van-der-waals
S 196 5x70 TM5 L 394 G.H5.26 hydrophobic
V 227 6x37 TM6 L 393 G.H5.25 hydrophobic
G 206 5x80 TM5 T 350 G.h4s6.03 hydrophobic
G 206 5x80 TM5 T 350 G.h4s6.03 van-der-waals
H 195 5x69 TM5 R 385 G.H5.17 polar
H 195 5x69 TM5 R 385 G.H5.17 hydrophobic
H 195 5x69 TM5 R 385 G.H5.17 van-der-waals
K 201 5x75 TM5 D 323 G.hgh4.13 hydrophobic
K 201 5x75 TM5 D 323 G.hgh4.13 van-der-waals
W 282 7x56 TM7 E 392 G.H5.24 hydrophobic
W 282 7x56 TM7 E 392 G.H5.24 van-der-waals
T 226 6x36 TM6 E 392 G.H5.24 polar
T 226 6x36 TM6 E 392 G.H5.24 van-der-waals
P 110 34x50 ICL2 I 383 G.H5.15 hydrophobic
P 110 34x50 ICL2 I 383 G.H5.15 van-der-waals
F 111 34x51 ICL2 F 219 G.S3.03 hydrophobic
L 114 34x54 ICL2 H 41 G.S1.02 hydrophobic
G 206 5x80 TM5 L 346 G.H4.16 hydrophobic
F 111 34x51 ICL2 C 379 G.H5.11 hydrophobic
F 111 34x51 ICL2 C 379 G.H5.11 van-der-waals
D 37 - ICL1 R 38 G.hns1.02 ionic
D 37 - ICL1 R 38 G.hns1.02 polar
D 37 - ICL1 R 38 G.hns1.02 van-der-waals
A 209 5x83 TM5 R 347 G.H4.17 hydrophobic
A 209 5x83 TM5 R 347 G.H4.17 van-der-waals
A 106 3x53 TM3 H 387 G.H5.19 polar
A 106 3x53 TM3 H 387 G.H5.19 hydrophobic
A 106 3x53 TM3 H 387 G.H5.19 van-der-waals
A 223 6x33 TM6 L 393 G.H5.25 polar
A 223 6x33 TM6 L 393 G.H5.25 hydrophobic
A 223 6x33 TM6 L 393 G.H5.25 van-der-waals
R 103 3x50 TM3 Y 391 G.H5.23 aromatic
R 103 3x50 TM3 Y 391 G.H5.23 hydrophobic
R 103 3x50 TM3 Y 391 G.H5.23 van-der-waals
H 195 5x69 TM5 D 381 G.H5.13 hydrophobic
H 195 5x69 TM5 D 381 G.H5.13 van-der-waals
A 209 5x83 TM5 D 343 G.H4.13 hydrophobic
A 209 5x83 TM5 D 343 G.H4.13 van-der-waals
M 202 5x76 TM5 T 350 G.h4s6.03 hydrophobic
M 202 5x76 TM5 T 350 G.h4s6.03 van-der-waals
H 195 5x69 TM5 Q 384 G.H5.16 polar
H 195 5x69 TM5 Q 384 G.H5.16 hydrophobic
H 195 5x69 TM5 Q 384 G.H5.16 van-der-waals
P 110 34x50 ICL2 Q 384 G.H5.16 hydrophobic
A 205 5x79 TM5 L 346 G.H4.16 hydrophobic
K 222 6x32 TM6 L 393 G.H5.25 hydrophobic
K 222 6x32 TM6 L 393 G.H5.25 van-der-waals
P 110 34x50 ICL2 R 380 G.H5.12 hydrophobic
I 199 5x73 TM5 Y 358 G.h4s6.20 hydrophobic
K 115 34x55 ICL2 A 39 G.hns1.03 hydrophobic
K 115 34x55 ICL2 A 39 G.hns1.03 van-der-waals
I 199 5x73 TM5 R 385 G.H5.17 hydrophobic
I 199 5x73 TM5 R 385 G.H5.17 van-der-waals
A 205 5x79 TM5 D 343 G.H4.13 hydrophobic
A 205 5x79 TM5 D 343 G.H4.13 van-der-waals
K 222 6x32 TM6 L 394 G.H5.26 polar
K 222 6x32 TM6 L 394 G.H5.26 hydrophobic
K 222 6x32 TM6 L 394 G.H5.26 van-der-waals
K 115 34x55 ICL2 K 216 G.s2s3.02 polar
K 115 34x55 ICL2 K 216 G.s2s3.02 van-der-waals
F 111 34x51 ICL2 F 376 G.H5.08 aromatic
F 111 34x51 ICL2 F 376 G.H5.08 hydrophobic
F 111 34x51 ICL2 F 376 G.H5.08 van-der-waals
A 192 5x66 TM5 L 393 G.H5.25 hydrophobic
I 107 3x54 TM3 Q 384 G.H5.16 polar
I 107 3x54 TM3 Q 384 G.H5.16 van-der-waals
D 37 - ICL1 K 34 G.HN.51 ionic
D 37 - ICL1 K 34 G.HN.51 polar
D 37 - ICL1 K 34 G.HN.51 hydrophobic
D 37 - ICL1 K 34 G.HN.51 van-der-waals
H 195 5x69 TM5 L 388 G.H5.20 hydrophobic
H 195 5x69 TM5 L 388 G.H5.20 van-der-waals
Y 113 34x53 ICL2 H 387 G.H5.19 hydrophobic
M 188 5x62 TM5 L 393 G.H5.25 hydrophobic
H 195 5x69 TM5 L 394 G.H5.26 hydrophobic
I 107 3x54 TM3 H 387 G.H5.19 hydrophobic
I 107 3x54 TM3 H 387 G.H5.19 van-der-waals
T 226 6x36 TM6 L 393 G.H5.25 hydrophobic
F 111 34x51 ICL2 H 41 G.S1.02 aromatic
F 111 34x51 ICL2 H 41 G.S1.02 hydrophobic
F 111 34x51 ICL2 H 41 G.S1.02 van-der-waals
F 111 34x51 ICL2 V 217 G.S3.01 hydrophobic
I 191 5x65 TM5 L 388 G.H5.20 hydrophobic
I 191 5x65 TM5 L 388 G.H5.20 van-der-waals
I 107 3x54 TM3 L 388 G.H5.20 hydrophobic
I 107 3x54 TM3 L 388 G.H5.20 van-der-waals
M 202 5x76 TM5 L 346 G.H4.16 hydrophobic