GPCR CLASS (FAMILY)
GPCR SPECIES
GPCR PREFERRED CHAIN
G PROTEIN (FAMILY)
G PROTEIN SPECIES
PDB CODE
RESOLUTION
REFERENCE
PUBLICATION DATE
LIGAND INTERACTIONS
LIGANDS
(4R,7R,18E)-4,7-dihydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide - Agonist pubchem
PHYSIOLOGICAL LIGANDS
N-palmitoylethanolamine, anandamide, N-oleoylethanolamide, SEA
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | ICL2 | K | 115 | 34x55 | G.s2s3 | K | 216 | G.s2s3.02 |
Van-der-waals | ICL2 | K | 115 | 34x55 | G.s2s3 | K | 216 | G.s2s3.02 |
Aromatic | ICL2 | F | 111 | 34x51 | G.H5 | F | 376 | G.H5.08 |
Hydrophobic | ICL2 | F | 111 | 34x51 | G.H5 | F | 376 | G.H5.08 |
Van-der-waals | ICL2 | F | 111 | 34x51 | G.H5 | F | 376 | G.H5.08 |
Hydrophobic | TM5 | H | 195 | 5x69 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM5 | H | 195 | 5x69 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM3 | A | 106 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM6 | V | 227 | 6x37 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM5 | A | 192 | 5x66 | G.H5 | L | 393 | G.H5.25 |
Aromatic | TM3 | R | 103 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | R | 103 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | R | 103 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM5 | H | 195 | 5x69 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL2 | P | 110 | 34x50 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM5 | E | 203 | 5x77 | G.h4s6 | T | 350 | G.h4s6.03 |
Van-der-waals | TM5 | E | 203 | 5x77 | G.h4s6 | T | 350 | G.h4s6.03 |
Ionic | TM6 | K | 222 | 6x32 | G.H5 | E | 392 | G.H5.24 |
Polar | TM6 | K | 222 | 6x32 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM6 | K | 222 | 6x32 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL2 | F | 111 | 34x51 | G.S3 | V | 217 | G.S3.01 |
Hydrophobic | ICL2 | F | 111 | 34x51 | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | F | 111 | 34x51 | G.H5 | I | 383 | G.H5.15 |
Hydrophobic | TM7 | W | 282 | 7x56 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM7 | W | 282 | 7x56 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM5 | G | 206 | 5x80 | G.H4 | L | 346 | G.H4.16 |
Hydrophobic | TM6 | K | 222 | 6x32 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | K | 222 | 6x32 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM5 | M | 188 | 5x62 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL2 | Y | 113 | 34x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM5 | A | 205 | 5x79 | G.H4 | D | 343 | G.H4.13 |
Van-der-waals | TM5 | A | 205 | 5x79 | G.H4 | D | 343 | G.H4.13 |
Polar | TM3 | I | 107 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | I | 107 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM5 | M | 202 | 5x76 | G.h4s6 | T | 350 | G.h4s6.03 |
Van-der-waals | TM5 | M | 202 | 5x76 | G.h4s6 | T | 350 | G.h4s6.03 |
Hydrophobic | TM5 | I | 199 | 5x73 | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | ICL2 | P | 110 | 34x50 | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | P | 110 | 34x50 | G.H5 | I | 383 | G.H5.15 |
Polar | TM5 | H | 195 | 5x69 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM5 | H | 195 | 5x69 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM5 | H | 195 | 5x69 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM5 | K | 201 | 5x75 | G.hgh4 | D | 323 | G.hgh4.13 |
Van-der-waals | TM5 | K | 201 | 5x75 | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | TM5 | A | 209 | 5x83 | G.H4 | D | 343 | G.H4.13 |
Van-der-waals | TM5 | A | 209 | 5x83 | G.H4 | D | 343 | G.H4.13 |
Ionic | ICL1 | D | 37 | - | G.hns1 | R | 38 | G.hns1.02 |
Polar | ICL1 | D | 37 | - | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL1 | D | 37 | - | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | TM5 | I | 191 | 5x65 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM5 | I | 191 | 5x65 | G.H5 | L | 388 | G.H5.20 |
Polar | TM6 | A | 223 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM6 | A | 223 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | A | 223 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM5 | A | 192 | 5x66 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM5 | A | 192 | 5x66 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | ICL2 | F | 111 | 34x51 | G.H5 | C | 379 | G.H5.11 |
Van-der-waals | ICL2 | F | 111 | 34x51 | G.H5 | C | 379 | G.H5.11 |
Hydrophobic | TM5 | I | 199 | 5x73 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM5 | I | 199 | 5x73 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM5 | A | 205 | 5x79 | G.H4 | L | 346 | G.H4.16 |
Hydrophobic | TM5 | S | 196 | 5x70 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL2 | K | 115 | 34x55 | G.hns1 | A | 39 | G.hns1.03 |
Van-der-waals | ICL2 | K | 115 | 34x55 | G.hns1 | A | 39 | G.hns1.03 |
Aromatic | ICL2 | F | 111 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | F | 111 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | F | 111 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | TM6 | T | 226 | 6x36 | G.H5 | L | 393 | G.H5.25 |
Ionic | ICL1 | D | 37 | - | G.HN | K | 34 | G.HN.51 |
Polar | ICL1 | D | 37 | - | G.HN | K | 34 | G.HN.51 |
Hydrophobic | ICL1 | D | 37 | - | G.HN | K | 34 | G.HN.51 |
Van-der-waals | ICL1 | D | 37 | - | G.HN | K | 34 | G.HN.51 |
Hydrophobic | TM5 | M | 202 | 5x76 | G.H4 | L | 346 | G.H4.16 |
Hydrophobic | ICL2 | P | 110 | 34x50 | G.H5 | R | 380 | G.H5.12 |
Polar | TM5 | H | 195 | 5x69 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM5 | H | 195 | 5x69 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM5 | H | 195 | 5x69 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | I | 107 | 3x54 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | I | 107 | 3x54 | G.H5 | Y | 391 | G.H5.23 |
Polar | TM3 | A | 106 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM3 | A | 106 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM3 | A | 106 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | L | 114 | 34x54 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | TM5 | A | 209 | 5x83 | G.H4 | R | 347 | G.H4.17 |
Van-der-waals | TM5 | A | 209 | 5x83 | G.H4 | R | 347 | G.H4.17 |
Hydrophobic | TM5 | H | 195 | 5x69 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM5 | H | 195 | 5x69 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM5 | G | 206 | 5x80 | G.h4s6 | T | 350 | G.h4s6.03 |
Van-der-waals | TM5 | G | 206 | 5x80 | G.h4s6 | T | 350 | G.h4s6.03 |
Hydrophobic | TM5 | M | 202 | 5x76 | G.S6 | P | 361 | G.S6.03 |
Van-der-waals | TM5 | M | 202 | 5x76 | G.S6 | P | 361 | G.S6.03 |
Polar | TM6 | K | 222 | 6x32 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM6 | K | 222 | 6x32 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | K | 222 | 6x32 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM3 | I | 107 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM3 | I | 107 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM5 | G | 206 | 5x80 | G.H4 | R | 347 | G.H4.17 |
Hydrophobic | TM3 | I | 107 | 3x54 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM3 | I | 107 | 3x54 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | F | 111 | 34x51 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | F | 111 | 34x51 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | ICL2 | F | 111 | 34x51 | G.S3 | F | 219 | G.S3.03 |
Polar | TM6 | T | 226 | 6x36 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM6 | T | 226 | 6x36 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM5 | A | 192 | 5x66 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM5 | A | 192 | 5x66 | G.H5 | L | 394 | G.H5.26 |