Refined structure (7F1S) of Gi1 - CCR5

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-02-01

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Structure
GPCR
Gα
Gβ
Gγ
Model
AlphaFold2-Multimer

REFINED G PROTEIN RESIDUES

Residue backbones - 216 from structure (61.0%), 138 from model (39.0%)
Residue sidechains - 168 from structure (47.5%), 186 from model (52.5%)
Segment Seq.num. AA CGN# Backbone from Sidechain from
G.HN 1 M G.HN.01 AF2 AF2
G.HN 2 G G.HN.02 AF2 AF2
G.HN 3 C G.HN.09 AF2 AF2
G.HN 4 T G.HN.10 AF2 AF2
G.HN 5 L G.HN.11 AF2 AF2
G.HN 6 S G.HN.30 Structure Structure
G.HN 7 A G.HN.31 Structure Structure
G.HN 8 E G.HN.32 Structure AF2
G.HN 9 D G.HN.33 Structure Structure
G.HN 10 K G.HN.34 Structure AF2
G.HN 11 A G.HN.35 Structure Structure
G.HN 12 A G.HN.36 Structure Structure
G.HN 13 V G.HN.37 Structure Structure
G.HN 14 E G.HN.38 Structure AF2
G.HN 15 R G.HN.39 Structure Structure
G.HN 16 S G.HN.40 Structure Structure
G.HN 17 K G.HN.41 Structure AF2
G.HN 18 M G.HN.42 Structure Structure
G.HN 19 I G.HN.43 Structure Structure
G.HN 20 D G.HN.44 Structure Structure
G.HN 21 R G.HN.45 Structure Structure
G.HN 22 N G.HN.46 Structure Structure
G.HN 23 L G.HN.47 Structure Structure
G.HN 24 R G.HN.48 Structure Structure
G.HN 25 E G.HN.49 Structure Structure
G.HN 26 D G.HN.50 Structure AF2
G.HN 27 G G.HN.51 Structure Structure
G.HN 28 E G.HN.52 Structure AF2
G.HN 29 K G.HN.53 Structure Structure
G.hns1 30 A G.hns1.01 Structure Structure
G.hns1 31 A G.hns1.02 Structure Structure
G.hns1 32 R G.hns1.03 Structure Structure
G.S1 33 E G.S1.01 Structure AF2
G.S1 34 V G.S1.02 Structure Structure
G.S1 35 K G.S1.03 Structure Structure
G.S1 36 L G.S1.04 Structure Structure
G.S1 37 L G.S1.05 Structure Structure
G.S1 38 L G.S1.06 Structure Structure
G.S1 39 L G.S1.07 Structure Structure
G.s1h1 40 G G.s1h1.01 Structure Structure
G.s1h1 41 A G.s1h1.02 Structure Structure
G.s1h1 42 G G.s1h1.03 Structure Structure
G.s1h1 43 E G.s1h1.04 Structure AF2
G.s1h1 44 S G.s1h1.05 Structure AF2
G.s1h1 45 G G.s1h1.06 Structure Structure
G.H1 46 K G.H1.01 Structure AF2
G.H1 47 S G.H1.02 Structure AF2
G.H1 48 T G.H1.03 Structure Structure
G.H1 49 I G.H1.04 Structure Structure
G.H1 50 V G.H1.05 Structure Structure
G.H1 51 K G.H1.06 Structure AF2
G.H1 52 Q G.H1.07 Structure AF2
G.H1 53 M G.H1.08 Structure AF2
G.H1 54 K G.H1.09 Structure Structure
G.H1 55 I G.H1.10 Structure AF2
G.H1 56 I G.H1.11 AF2 AF2
G.H1 57 H G.H1.12 AF2 AF2
G.h1ha 58 E G.h1ha.01 AF2 AF2
G.h1ha 59 A G.h1ha.02 AF2 AF2
G.h1ha 60 G G.h1ha.03 AF2 AF2
G.h1ha 61 Y G.h1ha.04 AF2 AF2
G.h1ha 62 S G.h1ha.05 AF2 AF2
H.HA 63 E H.HA.01 AF2 AF2
H.HA 64 E H.HA.02 AF2 AF2
H.HA 65 E H.HA.03 AF2 AF2
H.HA 66 C H.HA.04 AF2 AF2
H.HA 67 K H.HA.05 AF2 AF2
H.HA 68 Q H.HA.06 AF2 AF2
H.HA 69 Y H.HA.07 AF2 AF2
H.HA 70 K H.HA.08 AF2 AF2
H.HA 71 A H.HA.09 AF2 AF2
H.HA 72 V H.HA.10 AF2 AF2
H.HA 73 V H.HA.11 AF2 AF2
H.HA 74 Y H.HA.12 AF2 AF2
H.HA 75 S H.HA.13 AF2 AF2
H.HA 76 N H.HA.14 AF2 AF2
H.HA 77 T H.HA.15 AF2 AF2
H.HA 78 I H.HA.16 AF2 AF2
H.HA 79 Q H.HA.17 AF2 AF2
H.HA 80 S H.HA.18 AF2 AF2
H.HA 81 I H.HA.19 AF2 AF2
H.HA 82 I H.HA.20 AF2 AF2
H.HA 83 A H.HA.21 AF2 AF2
H.HA 84 I H.HA.22 AF2 AF2
H.HA 85 I H.HA.23 AF2 AF2
H.HA 86 R H.HA.24 AF2 AF2
H.HA 87 A H.HA.25 AF2 AF2
H.HA 88 M H.HA.26 AF2 AF2
H.HA 89 G H.HA.27 AF2 AF2
H.HA 90 R H.HA.28 AF2 AF2
H.HA 91 L H.HA.29 AF2 AF2
H.hahb 92 K H.hahb.01 AF2 AF2
H.hahb 93 I H.hahb.04 AF2 AF2
H.hahb 94 D H.hahb.05 AF2 AF2
H.hahb 95 F H.hahb.06 AF2 AF2
H.hahb 96 G H.hahb.07 AF2 AF2
H.hahb 97 D H.hahb.08 AF2 AF2
H.hahb 98 S H.hahb.09 AF2 AF2
H.HB 99 A H.HB.01 AF2 AF2
H.HB 100 R H.HB.02 AF2 AF2
H.HB 101 A H.HB.03 AF2 AF2
H.HB 102 D H.HB.04 AF2 AF2
H.HB 103 D H.HB.05 AF2 AF2
H.HB 104 A H.HB.06 AF2 AF2
H.HB 105 R H.HB.07 AF2 AF2
H.HB 106 Q H.HB.08 AF2 AF2
H.HB 107 L H.HB.09 AF2 AF2
H.HB 108 F H.HB.10 AF2 AF2
H.HB 109 V H.HB.11 AF2 AF2
H.HB 110 L H.HB.12 AF2 AF2
H.HB 111 A H.HB.13 AF2 AF2
H.HB 112 G H.HB.14 AF2 AF2
H.hbhc 113 A H.hbhc.01 AF2 AF2
H.hbhc 114 A H.hbhc.02 AF2 AF2
H.hbhc 115 E H.hbhc.03 AF2 AF2
H.hbhc 116 E H.hbhc.04 AF2 AF2
H.hbhc 117 G H.hbhc.12 AF2 AF2
H.hbhc 118 F H.hbhc.13 AF2 AF2
H.hbhc 119 M H.hbhc.14 AF2 AF2
H.hbhc 120 T H.hbhc.15 AF2 AF2
H.HC 121 A H.HC.01 AF2 AF2
H.HC 122 E H.HC.02 AF2 AF2
H.HC 123 L H.HC.03 AF2 AF2
H.HC 124 A H.HC.04 AF2 AF2
H.HC 125 G H.HC.05 AF2 AF2
H.HC 126 V H.HC.06 AF2 AF2
H.HC 127 I H.HC.07 AF2 AF2
H.HC 128 K H.HC.08 AF2 AF2
H.HC 129 R H.HC.09 AF2 AF2
H.HC 130 L H.HC.10 AF2 AF2
H.HC 131 W H.HC.11 AF2 AF2
H.HC 132 K H.HC.12 AF2 AF2
H.hchd 133 D H.hchd.01 AF2 AF2
H.HD 134 S H.HD.01 AF2 AF2
H.HD 135 G H.HD.02 AF2 AF2
H.HD 136 V H.HD.03 AF2 AF2
H.HD 137 Q H.HD.04 AF2 AF2
H.HD 138 A H.HD.05 AF2 AF2
H.HD 139 C H.HD.06 AF2 AF2
H.HD 140 F H.HD.07 AF2 AF2
H.HD 141 N H.HD.08 AF2 AF2
H.HD 142 R H.HD.09 AF2 AF2
H.HD 143 S H.HD.10 AF2 AF2
H.HD 144 R H.HD.11 AF2 AF2
H.HD 145 E H.HD.12 AF2 AF2
H.hdhe 146 Y H.hdhe.01 AF2 AF2
H.hdhe 147 Q H.hdhe.02 AF2 AF2
H.hdhe 148 L H.hdhe.03 AF2 AF2
H.hdhe 149 N H.hdhe.04 AF2 AF2
H.hdhe 150 D H.hdhe.05 AF2 AF2
H.HE 151 S H.HE.01 AF2 AF2
H.HE 152 A H.HE.02 AF2 AF2
H.HE 153 A H.HE.03 AF2 AF2
H.HE 154 Y H.HE.04 AF2 AF2
H.HE 155 Y H.HE.05 AF2 AF2
H.HE 156 L H.HE.06 AF2 AF2
H.HE 157 N H.HE.07 AF2 AF2
H.HE 158 D H.HE.08 AF2 AF2
H.HE 159 L H.HE.09 AF2 AF2
H.HE 160 D H.HE.10 AF2 AF2
H.HE 161 R H.HE.11 AF2 AF2
H.HE 162 I H.HE.12 AF2 AF2
H.HE 163 A H.HE.13 AF2 AF2
H.hehf 164 Q H.hehf.01 AF2 AF2
H.hehf 165 P H.hehf.02 AF2 AF2
H.hehf 166 N H.hehf.03 AF2 AF2
H.hehf 167 Y H.hehf.04 AF2 AF2
H.hehf 168 I H.hehf.05 AF2 AF2
H.hehf 169 P H.hehf.06 AF2 AF2
H.hehf 170 T H.hehf.07 AF2 AF2
H.HF 171 Q H.HF.01 AF2 AF2
H.HF 172 Q H.HF.02 AF2 AF2
H.HF 173 D H.HF.03 AF2 AF2
H.HF 174 V H.HF.04 AF2 AF2
H.HF 175 L H.HF.05 AF2 AF2
H.HF 176 R H.HF.06 AF2 AF2
G.hfs2 177 T G.hfs2.01 AF2 AF2
G.hfs2 178 R G.hfs2.02 AF2 AF2
G.hfs2 179 V G.hfs2.03 AF2 AF2
G.hfs2 180 K G.hfs2.04 AF2 AF2
G.hfs2 181 T G.hfs2.05 AF2 AF2
G.hfs2 182 T G.hfs2.06 Structure Structure
G.hfs2 183 G G.hfs2.07 Structure Structure
G.S2 184 I G.S2.01 Structure Structure
G.S2 185 V G.S2.02 Structure Structure
G.S2 186 E G.S2.03 Structure Structure
G.S2 187 T G.S2.04 Structure Structure
G.S2 188 H G.S2.05 Structure Structure
G.S2 189 F G.S2.06 Structure Structure
G.S2 190 T G.S2.07 Structure Structure
G.S2 191 F G.S2.08 Structure Structure
G.s2s3 192 K G.s2s3.01 Structure AF2
G.s2s3 193 D G.s2s3.02 Structure AF2
G.S3 194 L G.S3.01 Structure Structure
G.S3 195 H G.S3.02 Structure Structure
G.S3 196 F G.S3.03 Structure Structure
G.S3 197 K G.S3.04 Structure Structure
G.S3 198 M G.S3.05 Structure Structure
G.S3 199 F G.S3.06 Structure Structure
G.S3 200 D G.S3.07 Structure AF2
G.S3 201 V G.S3.08 Structure Structure
G.s3h2 202 G G.s3h2.01 Structure AF2
G.s3h2 203 G G.s3h2.02 Structure AF2
G.s3h2 204 Q G.s3h2.03 Structure Structure
G.H2 205 R G.H2.01 Structure AF2
G.H2 206 S G.H2.02 Structure Structure
G.H2 207 E G.H2.03 Structure AF2
G.H2 208 R G.H2.04 Structure Structure
G.H2 209 K G.H2.05 Structure AF2
G.H2 210 K G.H2.06 Structure AF2
G.H2 211 W G.H2.07 Structure Structure
G.H2 212 I G.H2.08 Structure Structure
G.H2 213 H G.H2.09 Structure Structure
G.H2 214 C G.H2.10 Structure Structure
G.h2s4 215 F G.h2s4.01 Structure Structure
G.h2s4 216 E G.h2s4.02 Structure AF2
G.h2s4 217 G G.h2s4.03 Structure Structure
G.h2s4 218 V G.h2s4.04 Structure Structure
G.h2s4 219 T G.h2s4.05 Structure Structure
G.S4 220 A G.S4.01 Structure Structure
G.S4 221 I G.S4.02 Structure Structure
G.S4 222 I G.S4.03 Structure Structure
G.S4 223 F G.S4.04 Structure Structure
G.S4 224 C G.S4.05 Structure Structure
G.S4 225 V G.S4.06 Structure Structure
G.S4 226 A G.S4.07 Structure Structure
G.s4h3 227 L G.s4h3.01 Structure Structure
G.s4h3 228 S G.s4h3.02 Structure Structure
G.s4h3 229 D G.s4h3.03 Structure AF2
G.s4h3 230 Y G.s4h3.04 Structure Structure
G.s4h3 231 D G.s4h3.05 Structure AF2
G.s4h3 232 L G.s4h3.06 Structure Structure
G.s4h3 233 V G.s4h3.07 Structure AF2
G.s4h3 234 L G.s4h3.08 AF2 AF2
G.s4h3 235 A G.s4h3.09 AF2 AF2
G.s4h3 236 E G.s4h3.10 AF2 AF2
G.s4h3 237 D G.s4h3.11 AF2 AF2
G.s4h3 238 E G.s4h3.12 AF2 AF2
G.s4h3 239 E G.s4h3.13 AF2 AF2
G.s4h3 240 M G.s4h3.14 AF2 AF2
G.s4h3 241 N G.s4h3.15 Structure Structure
G.H3 242 R G.H3.01 Structure Structure
G.H3 243 M G.H3.02 Structure Structure
G.H3 244 H G.H3.03 Structure Structure
G.H3 245 E G.H3.04 Structure AF2
G.H3 246 S G.H3.05 Structure Structure
G.H3 247 M G.H3.06 Structure Structure
G.H3 248 K G.H3.07 Structure AF2
G.H3 249 L G.H3.08 Structure Structure
G.H3 250 F G.H3.09 Structure Structure
G.H3 251 D G.H3.10 Structure Structure
G.H3 252 S G.H3.11 Structure Structure
G.H3 253 I G.H3.12 Structure Structure
G.H3 254 C G.H3.13 Structure Structure
G.H3 255 N G.H3.14 Structure Structure
G.H3 256 N G.H3.15 Structure Structure
G.H3 257 K G.H3.16 Structure AF2
G.H3 258 W G.H3.17 Structure Structure
G.H3 259 F G.H3.18 Structure Structure
G.h3s5 260 T G.h3s5.01 Structure Structure
G.h3s5 261 D G.h3s5.02 Structure AF2
G.h3s5 262 T G.h3s5.03 Structure Structure
G.S5 263 S G.S5.01 Structure Structure
G.S5 264 I G.S5.02 Structure Structure
G.S5 265 I G.S5.03 Structure Structure
G.S5 266 L G.S5.04 Structure Structure
G.S5 267 F G.S5.05 Structure Structure
G.S5 268 L G.S5.06 Structure Structure
G.S5 269 N G.S5.07 Structure Structure
G.s5hg 270 K G.s5hg.01 Structure Structure
G.HG 271 K G.HG.01 Structure Structure
G.HG 272 D G.HG.02 Structure AF2
G.HG 273 L G.HG.03 Structure Structure
G.HG 274 F G.HG.04 Structure Structure
G.HG 275 E G.HG.05 Structure AF2
G.HG 276 E G.HG.06 Structure AF2
G.HG 277 K G.HG.07 Structure Structure
G.HG 278 I G.HG.08 Structure Structure
G.HG 279 K G.HG.09 Structure AF2
G.HG 280 K G.HG.12 Structure AF2
G.HG 281 S G.HG.13 Structure Structure
G.HG 282 P G.HG.14 Structure Structure
G.HG 283 L G.HG.15 Structure Structure
G.HG 284 T G.HG.16 Structure Structure
G.HG 285 I G.HG.17 Structure Structure
G.hgh4 286 C G.hgh4.01 Structure Structure
G.hgh4 287 Y G.hgh4.02 Structure Structure
G.hgh4 288 P G.hgh4.03 Structure Structure
G.hgh4 289 E G.hgh4.04 Structure AF2
G.hgh4 290 Y G.hgh4.05 Structure AF2
G.hgh4 291 A G.hgh4.06 Structure Structure
G.hgh4 292 G G.hgh4.07 Structure Structure
G.hgh4 293 S G.hgh4.08 Structure AF2
G.H4 294 N G.H4.01 Structure Structure
G.H4 295 T G.H4.02 Structure Structure
G.H4 296 Y G.H4.03 Structure Structure
G.H4 297 E G.H4.04 Structure AF2
G.H4 298 E G.H4.05 Structure Structure
G.H4 299 A G.H4.06 Structure Structure
G.H4 300 A G.H4.07 Structure Structure
G.H4 301 A G.H4.08 Structure Structure
G.H4 302 Y G.H4.10 Structure Structure
G.H4 303 I G.H4.11 Structure Structure
G.H4 304 Q G.H4.12 Structure Structure
G.H4 305 C G.H4.13 Structure Structure
G.H4 306 Q G.H4.14 Structure Structure
G.H4 307 F G.H4.15 Structure Structure
G.H4 308 E G.H4.16 Structure Structure
G.H4 309 D G.H4.17 Structure Structure
G.h4s6 310 L G.h4s6.01 Structure Structure
G.h4s6 311 N G.h4s6.02 Structure Structure
G.h4s6 312 K G.h4s6.03 Structure Structure
G.h4s6 313 R G.h4s6.04 Structure Structure
G.h4s6 314 K G.h4s6.08 Structure Structure
G.h4s6 315 D G.h4s6.09 Structure AF2
G.h4s6 316 T G.h4s6.10 Structure AF2
G.h4s6 317 K G.h4s6.11 Structure Structure
G.h4s6 318 E G.h4s6.12 Structure AF2
G.S6 319 I G.S6.01 Structure Structure
G.S6 320 Y G.S6.02 Structure Structure
G.S6 321 T G.S6.03 Structure Structure
G.S6 322 H G.S6.04 Structure Structure
G.S6 323 F G.S6.05 Structure Structure
G.s6h5 324 T G.s6h5.01 Structure Structure
G.s6h5 325 C G.s6h5.02 Structure Structure
G.s6h5 326 A G.s6h5.03 Structure AF2
G.s6h5 327 T G.s6h5.04 Structure AF2
G.s6h5 328 D G.s6h5.05 Structure AF2
G.H5 329 T G.H5.01 Structure Structure
G.H5 330 K G.H5.02 Structure AF2
G.H5 331 N G.H5.03 Structure Structure
G.H5 332 V G.H5.04 Structure Structure
G.H5 333 Q G.H5.05 Structure Structure
G.H5 334 F G.H5.06 Structure Structure
G.H5 335 V G.H5.07 Structure Structure
G.H5 336 F G.H5.08 Structure Structure
G.H5 337 D G.H5.09 Structure Structure
G.H5 338 A G.H5.10 Structure Structure
G.H5 339 V G.H5.11 Structure Structure
G.H5 340 T G.H5.12 Structure Structure
G.H5 341 D G.H5.13 Structure Structure
G.H5 342 V G.H5.14 Structure Structure
G.H5 343 I G.H5.15 Structure Structure
G.H5 344 I G.H5.16 Structure Structure
G.H5 345 K G.H5.17 Structure Structure
G.H5 346 N G.H5.18 Structure Structure
G.H5 347 N G.H5.19 Structure Structure
G.H5 348 L G.H5.20 Structure Structure
G.H5 349 K G.H5.21 Structure Structure
G.H5 350 D G.H5.22 Structure Structure
G.H5 351 C G.H5.23 Structure Structure
G.H5 352 G G.H5.24 Structure Structure
G.H5 353 L G.H5.25 Structure Structure
G.H5 354 F G.H5.26 Structure Structure

REFINED GPCR RESIDUES

Residue backbones - 265 from structure (82.0%), 58 from model (18.0%)
Residue sidechains - 222 from structure (68.7%), 101 from model (31.3%)
Segment Seq.num. AA GPCRdb# Backbone from Sidechain from
N-term 1 M - AF2 AF2
N-term 2 D - AF2 AF2
N-term 3 Y - AF2 AF2
N-term 4 Q - AF2 AF2
N-term 5 V - AF2 AF2
N-term 6 S - AF2 AF2
N-term 7 S - AF2 AF2
N-term 8 P - AF2 AF2
N-term 9 I - AF2 AF2
N-term 10 Y - AF2 AF2
N-term 11 D - AF2 AF2
N-term 12 I - AF2 AF2
N-term 13 N - AF2 AF2
N-term 14 Y - AF2 AF2
N-term 15 Y - AF2 AF2
N-term 16 T - AF2 AF2
N-term 17 S - AF2 AF2
N-term 18 E - AF2 AF2
N-term 19 P - AF2 AF2
N-term 20 C - AF2 AF2
N-term 21 Q - AF2 AF2
TM1 22 K 1.24x24 AF2 AF2
TM1 23 I 1.25x25 AF2 AF2
TM1 24 N 1.26x26 AF2 AF2
TM1 25 V 1.27x27 AF2 AF2
TM1 26 K 1.28x28 AF2 AF2
TM1 27 Q 1.29x29 AF2 AF2
TM1 28 I 1.30x30 AF2 AF2
TM1 29 A 1.31x31 AF2 AF2
TM1 30 A 1.32x32 AF2 AF2
TM1 31 R 1.33x33 AF2 AF2
TM1 32 L 1.34x34 AF2 AF2
TM1 33 L 1.35x35 AF2 AF2
TM1 34 P 1.36x36 AF2 AF2
TM1 35 P 1.37x37 AF2 AF2
TM1 36 L 1.38x38 AF2 AF2
TM1 37 Y 1.39x39 AF2 AF2
TM1 38 S 1.40x40 AF2 AF2
TM1 39 L 1.41x41 AF2 AF2
TM1 40 V 1.42x42 AF2 AF2
TM1 41 F 1.43x43 AF2 AF2
TM1 42 I 1.44x44 AF2 AF2
TM1 43 F 1.45x45 AF2 AF2
TM1 44 G 1.46x46 Structure Structure
TM1 45 F 1.47x47 Structure Structure
TM1 46 V 1.48x48 Structure Structure
TM1 47 G 1.49x49 Structure Structure
TM1 48 N 1.50x50 Structure Structure
TM1 49 M 1.51x51 Structure AF2
TM1 50 L 1.52x52 Structure AF2
TM1 51 V 1.53x53 Structure Structure
TM1 52 I 1.54x54 Structure Structure
TM1 53 L 1.55x55 Structure AF2
TM1 54 I 1.56x56 Structure Structure
TM1 55 L 1.57x57 Structure Structure
TM1 56 I 1.58x58 Structure Structure
TM1 57 N 1.59x59 Structure AF2
TM1 58 C 1.60x60 Structure Structure
ICL1 59 K 12.48x48 Structure AF2
ICL1 60 R 12.49x49 Structure AF2
ICL1 61 L 12.50x50 Structure Structure
ICL1 62 K 12.51x51 Structure AF2
TM2 63 S 2.37x37 Structure Structure
TM2 64 M 2.38x38 Structure Structure
TM2 65 T 2.39x39 Structure AF2
TM2 66 D 2.40x40 Structure AF2
TM2 67 I 2.41x41 Structure Structure
TM2 68 Y 2.42x42 Structure Structure
TM2 69 L 2.43x43 Structure Structure
TM2 70 L 2.44x44 Structure Structure
TM2 71 N 2.45x45 Structure Structure
TM2 72 L 2.46x46 Structure Structure
TM2 73 A 2.47x47 Structure Structure
TM2 74 I 2.48x48 Structure Structure
TM2 75 S 2.49x49 Structure Structure
TM2 76 D 2.50x50 Structure Structure
TM2 77 L 2.51x51 Structure Structure
TM2 78 F 2.52x52 Structure Structure
TM2 79 F 2.53x53 Structure Structure
TM2 80 L 2.54x54 Structure Structure
TM2 81 L 2.55x55 Structure Structure
TM2 82 T 2.56x56 Structure Structure
TM2 83 V 2.57x57 Structure AF2
TM2 84 P 2.58x58 Structure Structure
TM2 85 F 2.59x59 Structure Structure
TM2 86 W 2.60x60 Structure Structure
TM2 87 A 2.61x61 Structure Structure
TM2 88 H 2.62x62 Structure Structure
TM2 89 Y 2.63x63 Structure Structure
TM2 90 A 2.64x64 Structure Structure
TM2 91 A 2.65x65 AF2 AF2
TM2 92 A 2.66x66 AF2 AF2
ECL1 93 Q 23.49x49 AF2 AF2
ECL1 94 W 23.50x50 AF2 AF2
ECL1 95 D 23.51x51 AF2 AF2
ECL1 96 F 23.52x52 Structure Structure
TM3 97 G 3.21x21 Structure Structure
TM3 98 N 3.22x22 Structure Structure
TM3 99 T 3.23x23 Structure Structure
TM3 100 M 3.24x24 Structure Structure
TM3 101 C 3.25x25 Structure Structure
TM3 102 Q 3.26x26 Structure AF2
TM3 103 L 3.27x27 Structure Structure
TM3 104 L 3.28x28 Structure Structure
TM3 105 T 3.29x29 Structure Structure
TM3 106 G 3.30x30 Structure Structure
TM3 107 L 3.31x31 Structure Structure
TM3 108 Y 3.32x32 Structure Structure
TM3 109 F 3.33x33 Structure Structure
TM3 110 I 3.34x34 Structure Structure
TM3 111 G 3.35x35 Structure Structure
TM3 112 F 3.36x36 Structure Structure
TM3 113 F 3.37x37 Structure Structure
TM3 114 S 3.38x38 Structure Structure
TM3 115 G 3.39x39 Structure Structure
TM3 116 I 3.40x40 Structure Structure
TM3 117 F 3.41x41 Structure Structure
TM3 118 F 3.42x42 Structure Structure
TM3 119 I 3.43x43 Structure Structure
TM3 120 I 3.44x44 Structure Structure
TM3 121 L 3.45x45 Structure Structure
TM3 122 L 3.46x46 Structure Structure
TM3 123 T 3.47x47 Structure Structure
TM3 124 I 3.48x48 Structure Structure
TM3 125 D 3.49x49 Structure Structure
TM3 126 R 3.50x50 Structure Structure
TM3 127 Y 3.51x51 Structure Structure
TM3 128 L 3.52x52 Structure Structure
TM3 129 A 3.53x53 Structure Structure
TM3 130 V 3.54x54 Structure Structure
TM3 131 V 3.55x55 Structure Structure
TM3 132 H 3.56x56 Structure Structure
ICL2 133 A 34.50x50 Structure Structure
ICL2 134 V 34.51x51 Structure Structure
ICL2 135 F 34.52x52 Structure Structure
ICL2 136 A 34.53x53 Structure Structure
ICL2 137 L 34.54x54 Structure Structure
ICL2 138 K 34.55x55 Structure Structure
ICL2 139 A 34.56x56 Structure Structure
ICL2 140 R 34.57x57 Structure Structure
TM4 141 T 4.38x38 Structure Structure
TM4 142 V 4.39x39 Structure Structure
TM4 143 T 4.40x40 Structure Structure
TM4 144 F 4.41x41 Structure Structure
TM4 145 G 4.42x42 Structure Structure
TM4 146 V 4.43x43 Structure Structure
TM4 147 V 4.44x44 Structure Structure
TM4 148 T 4.45x45 Structure Structure
TM4 149 S 4.46x46 Structure Structure
TM4 150 V 4.47x47 Structure Structure
TM4 151 I 4.48x48 Structure Structure
TM4 152 T 4.49x49 Structure Structure
TM4 153 W 4.50x50 Structure Structure
TM4 154 V 4.51x51 Structure Structure
TM4 155 V 4.52x52 Structure Structure
TM4 156 A 4.53x53 Structure Structure
TM4 157 V 4.54x54 Structure Structure
TM4 158 F 4.55x55 Structure Structure
TM4 159 A 4.56x56 Structure Structure
TM4 160 S 4.57x57 Structure Structure
TM4 161 L 4.58x59 Structure Structure
TM4 162 P 4.59x60 Structure Structure
TM4 163 G 4.60x61 Structure AF2
TM4 164 I 4.61x62 Structure Structure
TM4 165 I 4.62x63 Structure Structure
TM4 166 F 4.63x64 Structure Structure
TM4 167 T 4.64x65 Structure Structure
ECL2 168 R - Structure Structure
ECL2 169 S - Structure Structure
ECL2 170 Q - Structure Structure
ECL2 171 K - Structure AF2
ECL2 172 E - Structure AF2
ECL2 173 G - Structure Structure
ECL2 174 L - Structure Structure
ECL2 175 H - Structure AF2
ECL2 176 Y - Structure AF2
ECL2 177 T - Structure AF2
ECL2 178 C 45.50x50 Structure Structure
ECL2 179 S 45.51x51 Structure Structure
ECL2 180 S 45.52x52 Structure Structure
ECL2 181 H - Structure Structure
ECL2 182 F - Structure AF2
ECL2 183 P - Structure Structure
ECL2 184 Y - Structure AF2
ECL2 185 S - Structure Structure
TM5 186 Q 5.30x31 Structure AF2
TM5 187 Y 5.31x32 Structure Structure
TM5 188 Q 5.32x33 Structure AF2
TM5 189 F 5.33x34 Structure AF2
TM5 190 W 5.34x35 Structure Structure
TM5 191 K 5.35x36 Structure AF2
TM5 192 N 5.36x37 Structure AF2
TM5 193 F 5.37x38 Structure Structure
TM5 194 Q 5.38x39 Structure Structure
TM5 195 T 5.39x40 Structure Structure
TM5 196 L 5.40x41 Structure AF2
TM5 197 K 5.41x42 Structure Structure
TM5 198 I 5.42x43 Structure Structure
TM5 199 V 5.43x44 Structure Structure
TM5 200 I 5.44x45 Structure Structure
TM5 201 L 5.45x46 Structure Structure
TM5 202 G 5.46x461 Structure Structure
TM5 203 L 5.47x47 Structure Structure
TM5 204 V 5.48x48 Structure Structure
TM5 205 L 5.49x49 Structure Structure
TM5 206 P 5.50x50 Structure Structure
TM5 207 L 5.51x51 Structure Structure
TM5 208 L 5.52x52 Structure Structure
TM5 209 V 5.53x53 Structure Structure
TM5 210 M 5.54x54 Structure Structure
TM5 211 V 5.55x55 Structure Structure
TM5 212 I 5.56x56 Structure Structure
TM5 213 C 5.57x57 Structure Structure
TM5 214 Y 5.58x58 Structure Structure
TM5 215 S 5.59x59 Structure Structure
TM5 216 G 5.60x60 Structure Structure
TM5 217 I 5.61x61 Structure Structure
TM5 218 L 5.62x62 Structure Structure
TM5 219 K 5.63x63 Structure Structure
TM5 220 T 5.64x64 Structure Structure
TM5 221 L 5.65x65 Structure Structure
TM5 222 L 5.66x66 Structure Structure
TM5 223 R 5.67x67 Structure Structure
TM5 224 C 5.68x68 Structure Structure
ICL3 225 R - Structure Structure
TM6 226 N 6.26x26 Structure Structure
TM6 227 E 6.27x27 Structure AF2
TM6 228 K 6.28x28 Structure AF2
TM6 229 K 6.29x29 Structure Structure
TM6 230 R 6.30x30 Structure Structure
TM6 231 H 6.31x31 Structure Structure
TM6 232 R 6.32x32 Structure Structure
TM6 233 A 6.33x33 Structure Structure
TM6 234 V 6.34x34 Structure Structure
TM6 235 R 6.35x35 Structure Structure
TM6 236 L 6.36x36 Structure Structure
TM6 237 I 6.37x37 Structure Structure
TM6 238 F 6.38x38 Structure Structure
TM6 239 T 6.39x39 Structure Structure
TM6 240 I 6.40x40 Structure Structure
TM6 241 M 6.41x41 Structure Structure
TM6 242 I 6.42x42 Structure Structure
TM6 243 V 6.43x43 Structure Structure
TM6 244 Y 6.44x44 Structure Structure
TM6 245 F 6.45x45 Structure Structure
TM6 246 L 6.46x46 Structure Structure
TM6 247 F 6.47x47 Structure Structure
TM6 248 W 6.48x48 Structure Structure
TM6 249 A 6.49x49 Structure Structure
TM6 250 P 6.50x50 Structure Structure
TM6 251 Y 6.51x51 Structure Structure
TM6 252 N 6.52x52 Structure Structure
TM6 253 I 6.53x53 Structure AF2
TM6 254 V 6.54x54 Structure Structure
TM6 255 L 6.55x55 Structure Structure
TM6 256 L 6.56x56 Structure Structure
TM6 257 L 6.57x57 Structure AF2
TM6 258 N 6.58x58 Structure Structure
TM6 259 T 6.59x59 Structure Structure
TM6 260 F 6.60x60 Structure Structure
TM6 261 Q 6.61x61 Structure Structure
TM6 262 E 6.62x62 Structure AF2
TM6 263 F 6.63x63 Structure Structure
TM6 264 F 6.64x64 Structure AF2
TM6 265 G 6.65x65 Structure Structure
ECL3 266 L - Structure AF2
ECL3 267 N - Structure AF2
TM7 268 N 7.24x23 Structure AF2
TM7 269 C 7.25x24 Structure Structure
TM7 270 S 7.26x25 Structure Structure
TM7 271 S 7.27x26 Structure Structure
TM7 272 S 7.28x27 Structure Structure
TM7 273 N 7.29x28 Structure AF2
TM7 274 R 7.30x29 Structure AF2
TM7 275 L 7.31x30 Structure Structure
TM7 276 D 7.32x31 Structure AF2
TM7 277 Q 7.33x32 Structure Structure
TM7 278 A 7.34x33 Structure Structure
TM7 279 M 7.35x34 Structure Structure
TM7 280 Q 7.36x35 Structure Structure
TM7 281 V 7.37x36 Structure Structure
TM7 282 T 7.38x37 Structure Structure
TM7 283 E 7.39x38 Structure Structure
TM7 284 T 7.40x39 Structure Structure
TM7 285 L 7.41x40 Structure Structure
TM7 286 G 7.42x41 Structure Structure
TM7 287 M 7.43x42 Structure AF2
TM7 288 T 7.44x43 Structure Structure
TM7 289 H 7.45x45 Structure Structure
TM7 290 C 7.46x46 Structure Structure
TM7 291 C 7.47x47 Structure Structure
TM7 292 I 7.48x48 Structure Structure
TM7 293 N 7.49x49 Structure Structure
TM7 294 P 7.50x50 Structure Structure
TM7 295 I 7.51x51 Structure Structure
TM7 296 I 7.52x52 Structure Structure
TM7 297 Y 7.53x53 Structure Structure
TM7 298 A 7.54x54 Structure Structure
TM7 299 F 7.55x55 Structure Structure
TM7 300 V 7.56x56 Structure Structure
H8 301 G 8.47x47 Structure Structure
H8 302 E 8.48x48 Structure AF2
H8 303 K 8.49x49 Structure AF2
H8 304 F 8.50x50 Structure Structure
H8 305 R 8.51x51 Structure Structure
H8 306 N 8.52x52 Structure AF2
H8 307 Y 8.53x53 Structure Structure
H8 308 L 8.54x54 Structure Structure
H8 309 L 8.55x55 Structure Structure
H8 310 V 8.56x56 Structure AF2
H8 311 F 8.57x57 Structure Structure
H8 312 F 8.58x58 Structure Structure
H8 313 Q 8.59x59 Structure AF2
C-term 314 K - AF2 AF2
C-term 315 H - AF2 AF2
C-term 316 I - AF2 AF2
C-term 317 A - AF2 AF2
C-term 318 K - AF2 AF2
C-term 319 R - AF2 AF2
C-term 320 F - AF2 AF2
C-term 321 C - AF2 AF2
C-term 322 K - AF2 AF2
C-term 323 C - AF2 AF2



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM4 T 141 4x38 G.hns1 R 32 G.hns1.03
Van-der-waals TM4 T 141 4x38 G.hns1 R 32 G.hns1.03
Hydrophobic TM7 V 300 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 V 300 7x56 G.H5 G 352 G.H5.24
Polar TM6 R 232 6x32 G.H5 L 353 G.H5.25
Van-der-waals TM6 R 232 6x32 G.H5 L 353 G.H5.25
Hydrophobic ICL2 A 133 34x50 G.H5 T 340 G.H5.12
Van-der-waals ICL2 A 133 34x50 G.H5 T 340 G.H5.12
Polar ICL3 R 225 - G.S6 I 319 G.S6.01
Hydrophobic ICL3 R 225 - G.S6 I 319 G.S6.01
Van-der-waals ICL3 R 225 - G.S6 I 319 G.S6.01
Polar TM6 N 226 6x26 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 N 226 6x26 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM5 C 224 5x68 G.H5 F 354 G.H5.26
Hydrophobic TM3 V 130 3x54 G.H5 L 348 G.H5.20
Polar H8 G 301 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 G 301 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL2 V 134 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 V 134 34x51 G.S3 L 194 G.S3.01
Hydrophobic H8 G 301 8x47 G.H5 F 354 G.H5.26
Hydrophobic ICL2 A 133 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 A 133 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL2 A 133 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM5 C 224 5x68 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 C 224 5x68 G.h4s6 E 318 G.h4s6.12
Polar TM5 C 224 5x68 G.H5 K 345 G.H5.17
Hydrophobic TM5 C 224 5x68 G.H5 K 345 G.H5.17
Van-der-waals TM5 C 224 5x68 G.H5 K 345 G.H5.17
Hydrophobic ICL3 R 225 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 R 225 - G.S6 Y 320 G.S6.02
Polar TM3 A 129 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 129 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM6 I 237 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 126 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 126 3x50 G.H5 L 353 G.H5.25
Polar TM4 T 141 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 T 141 4x38 G.HN E 28 G.HN.52
Hydrophobic TM6 K 228 6x28 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 K 228 6x28 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM3 A 129 3x53 G.H5 C 351 G.H5.23
Polar TM3 R 126 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 126 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 126 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 130 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 V 130 3x54 G.H5 I 344 G.H5.16
Polar ICL2 K 138 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 K 138 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 K 138 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 L 221 5x65 G.H5 L 348 G.H5.20
Polar ICL2 R 140 34x57 G.hns1 R 32 G.hns1.03
Polar ICL2 L 137 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 137 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 137 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 137 34x54 G.H5 I 343 G.H5.15
Hydrophobic ICL2 L 137 34x54 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 137 34x54 G.S3 L 194 G.S3.01
Hydrophobic TM5 R 223 5x67 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 223 5x67 G.H5 I 344 G.H5.16
Ionic TM5 R 223 5x67 G.H5 D 341 G.H5.13
Polar TM5 R 223 5x67 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 223 5x67 G.H5 D 341 G.H5.13
Hydrophobic TM6 A 233 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 A 233 6x33 G.H5 F 354 G.H5.26
Aromatic TM6 K 229 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 K 229 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 229 6x29 G.H5 F 354 G.H5.26
Hydrophobic H8 K 303 8x49 G.H5 K 349 G.H5.21
Van-der-waals TM7 V 300 7x56 G.H5 F 354 G.H5.26
Hydrophobic H8 E 302 8x48 G.H5 K 349 G.H5.21
Ionic ICL3 R 225 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 R 225 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 R 225 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 225 - G.h4s6 E 318 G.h4s6.12
Polar TM6 R 232 6x32 G.H5 F 354 G.H5.26
Polar H8 E 302 8x48 G.H5 F 354 G.H5.26
Hydrophobic H8 E 302 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 E 302 8x48 G.H5 F 354 G.H5.26
Hydrophobic ICL2 V 134 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 V 134 34x51 G.H5 F 336 G.H5.08