BB3 receptor - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

9K07

RESOLUTION

2.8 Å

REFERENCE

PUBLICATION DATE

Aug. 27, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

33 interactions (Click to see)

LIGANDS

DSO-5a - Agonist

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 H 258 - G.H3 W 129 G.H3.13
Polar TM6 Q 262 6x26 G.H5 Q 237 G.H5.17
Hydrophobic TM6 Q 262 6x26 G.H5 Q 237 G.H5.17
Hydrophobic ICL3 P 252 - G.S6 Y 212 G.S6.02
Hydrophobic ICL2 R 155 - G.H5 I 235 G.H5.15
Polar TM3 A 148 3x53 G.H5 N 239 G.H5.19
Hydrophobic TM3 A 148 3x53 G.H5 N 239 G.H5.19
Van-der-waals TM3 A 148 3x53 G.H5 N 239 G.H5.19
Hydrophobic ICL2 L 153 - G.H5 K 232 G.H5.12
Hydrophobic TM5 L 244 5x65 G.H5 L 240 G.H5.20
Polar H8 S 334 8x47 G.H5 N 244 G.H5.24
Hydrophobic H8 S 334 8x47 G.H5 N 244 G.H5.24
Van-der-waals H8 S 334 8x47 G.H5 N 244 G.H5.24
Hydrophobic ICL3 P 252 - G.h4s6 I 210 G.h4s6.20
Ionic ICL3 E 254 - G.H4 R 194 G.H4.12
Hydrophobic TM7 L 333 7x56 G.H5 V 246 G.H5.26
Van-der-waals TM7 L 333 7x56 G.H5 V 246 G.H5.26
Hydrophobic ICL2 L 153 - G.H5 I 235 G.H5.15
Van-der-waals ICL2 L 153 - G.H5 I 235 G.H5.15
Hydrophobic TM5 L 244 5x65 G.H5 L 236 G.H5.16
Polar TM3 D 144 3x49 G.H5 Y 243 G.H5.23
Hydrophobic TM3 D 144 3x49 G.H5 Y 243 G.H5.23
Van-der-waals TM3 D 144 3x49 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 P 152 - G.H5 L 236 G.H5.16
Hydrophobic ICL2 L 153 - G.S1 L 34 G.S1.02
Hydrophobic TM7 L 333 7x56 G.H5 L 245 G.H5.25
Van-der-waals TM7 L 333 7x56 G.H5 L 245 G.H5.25
Polar ICL2 P 152 - G.H5 N 239 G.H5.19
Van-der-waals ICL2 P 152 - G.H5 N 239 G.H5.19
Polar TM5 N 250 5x71 G.H5 N 229 G.H5.09
Hydrophobic ICL3 H 258 - G.h4s6 I 210 G.h4s6.20
Van-der-waals ICL3 H 258 - G.h4s6 I 210 G.h4s6.20
Hydrophobic TM3 A 148 3x53 G.H5 Y 243 G.H5.23
Van-der-waals TM3 A 148 3x53 G.H5 Y 243 G.H5.23
Hydrophobic ICL2 P 152 - G.H5 I 235 G.H5.15
Van-der-waals ICL2 P 152 - G.H5 I 235 G.H5.15
Hydrophobic ICL2 L 153 - G.S3 V 79 G.S3.01
Van-der-waals ICL2 L 153 - G.S3 V 79 G.S3.01
Hydrophobic TM2 P 82 2x39 G.H5 Y 243 G.H5.23
Hydrophobic TM6 R 266 6x30 G.H5 L 240 G.H5.20
Hydrophobic ICL2 R 155 - G.S1 L 34 G.S1.02
Van-der-waals ICL2 R 155 - G.S1 L 34 G.S1.02
Hydrophobic ICL3 E 255 - G.H4 V 198 G.H4.16
Van-der-waals ICL3 E 255 - G.H4 V 198 G.H4.16
Hydrophobic TM6 I 269 6x33 G.H5 L 240 G.H5.20
Hydrophobic TM3 V 149 3x54 G.H5 L 240 G.H5.20
Van-der-waals TM3 V 149 3x54 G.H5 L 240 G.H5.20
Hydrophobic ICL2 L 153 - G.H5 F 228 G.H5.08
Hydrophobic ICL3 H 258 - G.h4s6 G 207 G.h4s6.11
Polar TM6 R 266 6x30 G.H5 Q 237 G.H5.17
Van-der-waals TM6 R 266 6x30 G.H5 Q 237 G.H5.17
Ionic ICL3 E 255 - G.H4 R 194 G.H4.12
Hydrophobic ICL3 E 255 - G.H4 R 194 G.H4.12
Polar TM2 N 83 2x40 G.H5 N 244 G.H5.24
Van-der-waals TM2 N 83 2x40 G.H5 N 244 G.H5.24
Hydrophobic TM3 R 145 3x50 G.H5 L 245 G.H5.25
Polar ICL3 H 258 - G.h4s6 S 204 G.h4s6.08
Ionic TM6 R 266 6x30 G.H5 D 233 G.H5.13
Polar TM6 R 266 6x30 G.H5 D 233 G.H5.13
Hydrophobic TM6 R 266 6x30 G.H5 D 233 G.H5.13
Van-der-waals TM6 R 266 6x30 G.H5 D 233 G.H5.13
Hydrophobic ICL2 P 152 - G.H5 K 232 G.H5.12
Hydrophobic TM6 Q 262 6x26 G.h4s6 I 210 G.h4s6.20
Polar H8 K 335 8x48 G.H5 V 246 G.H5.26
Hydrophobic TM2 P 82 2x39 G.H5 E 242 G.H5.22
Van-der-waals TM2 P 82 2x39 G.H5 E 242 G.H5.22
Hydrophobic TM6 I 269 6x33 G.H5 V 246 G.H5.26
Van-der-waals TM6 I 269 6x33 G.H5 V 246 G.H5.26
Polar ICL2 R 155 - G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 R 155 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 R 155 - G.hns1 R 31 G.hns1.02
Hydrophobic TM6 R 266 6x30 G.H5 L 236 G.H5.16
Van-der-waals TM6 R 266 6x30 G.H5 L 236 G.H5.16
Hydrophobic TM6 I 269 6x33 G.H5 L 245 G.H5.25
Van-der-waals TM6 I 269 6x33 G.H5 L 245 G.H5.25
Polar H8 S 334 8x47 G.H5 V 246 G.H5.26
Hydrophobic H8 S 334 8x47 G.H5 V 246 G.H5.26
Hydrophobic TM7 L 330 7x53 G.H5 N 244 G.H5.24
Van-der-waals TM7 L 330 7x53 G.H5 N 244 G.H5.24
Polar ICL3 H 258 - G.h4s6 H 209 G.h4s6.13
Van-der-waals ICL3 H 258 - G.h4s6 H 209 G.h4s6.13
Hydrophobic TM3 V 149 3x54 G.H5 L 245 G.H5.25
Hydrophobic TM3 R 145 3x50 G.H5 Y 243 G.H5.23