PAR2 - Gq

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gq/11

G PROTEIN SPECIES

Homo sapiens

PDB CODE

8ZMD

RESOLUTION

3.3 Å

REFERENCE

10.1038/S41421-025-00851-8

PUBLICATION DATE

May 28, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

No ligands

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 I 289 6x38 G.H5 L 393 G.H5.25
Polar TM2 H 108 2x37 G.H5 Y 391 G.H5.23
Aromatic TM2 H 108 2x37 G.H5 Y 391 G.H5.23
Hydrophobic TM2 H 108 2x37 G.H5 Y 391 G.H5.23
Van-der-waals TM2 H 108 2x37 G.H5 Y 391 G.H5.23
Polar TM6 K 281 6x30 G.h4s6 G 355 G.h4s6.11
Hydrophobic ICL3 M 274 - G.H5 L 384 G.H5.16
Van-der-waals ICL3 M 274 - G.H5 L 384 G.H5.16
Ionic TM2 H 108 2x37 G.H5 E 390 G.H5.22
Polar TM2 H 108 2x37 G.H5 E 390 G.H5.22
Hydrophobic TM2 H 108 2x37 G.H5 E 390 G.H5.22
Van-der-waals TM2 H 108 2x37 G.H5 E 390 G.H5.22
Hydrophobic ICL3 N 277 - G.S6 Y 360 G.S6.02
Polar TM6 R 284 6x33 G.H5 V 394 G.H5.26
Hydrophobic TM6 R 284 6x33 G.H5 V 394 G.H5.26
Van-der-waals TM6 R 284 6x33 G.H5 V 394 G.H5.26
Hydrophobic ICL2 P 180 - G.H5 I 383 G.H5.15
Hydrophobic ICL3 N 277 - G.h4s6 I 358 G.h4s6.20
Hydrophobic TM3 I 177 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 177 3x54 G.H5 L 388 G.H5.20
Polar TM6 S 278 6x27 G.H5 Q 385 G.H5.17
Hydrophobic TM6 S 278 6x27 G.H5 Q 385 G.H5.17
Van-der-waals TM6 S 278 6x27 G.H5 Q 385 G.H5.17
Hydrophobic TM6 A 285 6x34 G.H5 V 394 G.H5.26
Polar TM6 S 278 6x27 G.H5 D 381 G.H5.13
Van-der-waals TM6 S 278 6x27 G.H5 D 381 G.H5.13
Hydrophobic TM3 I 177 3x54 G.H5 N 387 G.H5.19
Hydrophobic TM3 Q 172 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 I 177 3x54 G.H5 L 384 G.H5.16
Van-der-waals TM3 I 177 3x54 G.H5 L 384 G.H5.16
Hydrophobic TM3 V 176 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 V 176 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 269 5x65 G.H5 L 384 G.H5.16
Hydrophobic TM3 R 173 3x50 G.H5 L 393 G.H5.25
Hydrophobic TM3 V 176 3x53 G.H5 N 387 G.H5.19
Van-der-waals TM3 V 176 3x53 G.H5 N 387 G.H5.19
Hydrophobic TM2 A 110 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM5 M 265 5x61 G.H5 L 393 G.H5.25
Hydrophobic TM6 K 281 6x30 G.H5 V 394 G.H5.26
Polar ICL2 P 180 - G.H5 N 387 G.H5.19
Hydrophobic ICL3 D 275 - G.H5 D 381 G.H5.13
Hydrophobic ICL3 D 275 - G.S6 Y 360 G.S6.02
Van-der-waals ICL3 D 275 - G.S6 Y 360 G.S6.02
Hydrophobic TM6 L 288 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 288 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM2 M 114 2x43 G.H5 N 392 G.H5.24
Van-der-waals TM2 M 114 2x43 G.H5 N 392 G.H5.24
Polar ICL4 S 348 - G.H5 N 392 G.H5.24
Hydrophobic ICL4 S 348 - G.H5 N 392 G.H5.24
Van-der-waals ICL4 S 348 - G.H5 N 392 G.H5.24