μ receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Bos taurus

PDB CODE

9XC6

RESOLUTION

3.0 Å

REFERENCE

PUBLICATION DATE

July 8, 2026

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

53 interactions (Click to see)

LIGANDS

(-)-methadone - Agonist pubchem gtoplig chembl_ligand drugbank drug_central pubchem gtoplig chembl_ligand drug_central drugbank pubchem ,

BMS-986187 - Ago-PAM pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

[Met]enkephalin (Human), dynorphin A-(1-8) (Human), dynorphin A (Human), dynorphin A-(1-13) (Human), β-endorphin (Mouse), endomorphin-1 (Human), β-endorphin (Rat), dynorphin B (Human), β-endorphin (Human), [Leu]enkephalin (Human), endomorphin-2 (Human)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 261 5x65 G.H5 L 348 G.H5.20
Polar ICL2 R 181 34x57 G.H5 N 347 G.H5.19
Polar TM6 K 273 6x26 G.h4s6 K 314 G.h4s6.08
Polar TM6 R 279 6x32 G.H5 L 353 G.H5.25
Van-der-waals TM6 R 279 6x32 G.H5 L 353 G.H5.25
Hydrophobic H8 D 342 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 D 342 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL3 R 265 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 R 265 - G.S6 Y 320 G.S6.02
Van-der-waals TM6 R 279 6x32 G.H5 F 354 G.H5.26
Polar ICL2 R 181 34x57 G.H5 C 351 G.H5.23
Hydrophobic ICL2 R 181 34x57 G.H5 C 351 G.H5.23
Hydrophobic TM6 N 276 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 N 276 6x29 G.H5 F 354 G.H5.26
Hydrophobic ICL2 P 174 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 174 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL3 V 264 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 L 178 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 P 174 34x50 G.H5 T 340 G.H5.12
Ionic ICL3 R 265 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 R 265 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 R 265 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 265 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 I 280 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 280 6x33 G.H5 L 353 G.H5.25
Polar H8 E 343 8x48 G.H5 G 352 G.H5.24
Hydrophobic H8 E 343 8x48 G.H5 G 352 G.H5.24
Hydrophobic TM6 K 273 6x26 G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL2 P 174 34x50 G.H5 I 344 G.H5.16
Polar H8 N 344 8x49 G.H5 D 350 G.H5.22
Hydrophobic ICL3 M 266 - G.H5 I 344 G.H5.16
Hydrophobic TM3 R 167 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 167 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 178 34x54 G.H5 I 343 G.H5.15
Ionic ICL2 D 179 34x55 G.hns1 R 32 G.hns1.03
Polar ICL2 D 179 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 D 179 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 D 179 34x55 G.hns1 R 32 G.hns1.03
Polar ICL3 R 265 - G.S6 I 319 G.S6.01
Van-der-waals ICL3 R 265 - G.S6 I 319 G.S6.01
Hydrophobic TM6 M 283 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM5 M 257 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 M 257 5x61 G.H5 L 353 G.H5.25
Hydrophobic H8 E 343 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 E 343 8x48 G.H5 F 354 G.H5.26
Polar ICL3 R 265 - G.H5 D 341 G.H5.13
Hydrophobic TM3 V 171 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 171 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM3 A 170 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 170 3x53 G.H5 C 351 G.H5.23
Polar TM3 R 167 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 167 3x50 G.H5 C 351 G.H5.23
Polar TM2 T 105 2x39 G.H5 D 350 G.H5.22
Polar H8 N 344 8x49 G.H5 K 349 G.H5.21
Ionic TM4 R 184 4x40 G.HN E 28 G.HN.52
Polar TM3 A 170 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 170 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 170 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 R 260 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM3 V 171 3x54 G.H5 I 344 G.H5.16
Hydrophobic ICL3 M 266 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 M 266 - G.H5 K 345 G.H5.17
Ionic ICL2 R 181 34x57 G.H5 D 350 G.H5.22
Polar ICL2 R 181 34x57 G.H5 D 350 G.H5.22
Hydrophobic ICL2 R 181 34x57 G.H5 D 350 G.H5.22
Van-der-waals ICL2 R 181 34x57 G.H5 D 350 G.H5.22
Hydrophobic ICL3 L 267 - G.H5 L 348 G.H5.20
Hydrophobic ICL3 M 266 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 M 266 - G.H5 D 341 G.H5.13
Ionic TM6 K 273 6x26 G.h4s6 E 318 G.h4s6.12
Polar TM6 K 273 6x26 G.h4s6 E 318 G.h4s6.12