PDB
9XC6
Resolution
3.0 Å
Released
July 8, 2026
Receptor
μ
Class
A
Species
Homo sapiens
Ligands
BMS-986187
(-)-methadone
Function
Ago-PAM
Agonist
Reference
—
BMS-986187 (-)-methadone

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Ligand Amino Acid Generic Number Segment Interaction Type
BMS-986187 I144 3.27x27 TM3 hydrophobic
(-)-methadone D149 3.32x32 TM3 polar (charge-assisted hydrogen bond)
(-)-methadone Y150 3.33x33 TM3 hydrophobic
(-)-methadone Y150 3.33x33 TM3 Van der Waals
BMS-986187 Y151 3.34x34 TM3 hydrophobic
BMS-986187 N152 3.35x35 TM3 polar (hydrogen bond)
BMS-986187 N152 3.35x35 TM3 Van der Waals
(-)-methadone M153 3.36x36 TM3 hydrophobic
(-)-methadone M153 3.36x36 TM3 Van der Waals
(-)-methadone F154 3.37x37 TM3 Van der Waals
(-)-methadone F154 3.37x37 TM3 aromatic (face-to-edge)
BMS-986187 S198 4.54x54 TM4 Van der Waals
BMS-986187 G201 4.57x57 TM4 Van der Waals
BMS-986187 M205 4.61x61 TM4 Van der Waals
BMS-986187 M205 4.61x61 TM4 hydrophobic
(-)-methadone A242 5.46x461 TM5 Van der Waals
(-)-methadone W295 6.48x48 TM6 aromatic (edge-to-face)
(-)-methadone W295 6.48x48 TM6 Van der Waals
(-)-methadone I298 6.51x51 TM6 hydrophobic
(-)-methadone I298 6.51x51 TM6 Van der Waals
(-)-methadone H299 6.52x52 TM6 Van der Waals
(-)-methadone I324 7.39x38 TM7 hydrophobic
(-)-methadone I324 7.39x38 TM7 Van der Waals
(-)-methadone G327 7.42x41 TM7 Van der Waals
(-)-methadone Y328 7.43x42 TM7 hydrophobic
(-)-methadone Y328 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A A P T N A S N C T D A L A Y S S C S P A P S P G S W V N L S H L D G N L S D P C G P N R T D L G G R D S L C P P T G S P S N-termC-term P T S S N I E Q Q N S T R I R Q N T R D H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M I T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G T I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I I N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L V T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I I N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
TM3
3x27 3.27x27 I144
3x32 3.32x32 D149
3x33 3.33x33 Y150
3x34 3.34x34 Y151
3x35 3.35x35 N152
3x36 3.36x36 M153
3x37 3.37x37 F154
TM4
4x54 4.54x54 S198
4x57 4.57x57 G201
4x61 4.61x61 M205
TM5
5x461 5.46x461 A242
TM6
6x48 6.48x48 W295
6x51 6.51x51 I298
6x52 6.52x52 H299
TM7
7x38 7.39x38 I324
7x41 7.42x41 G327
7x42 7.43x42 Y328