P2Y12 receptor - Gi2

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.0 Å

REFERENCE

PUBLICATION DATE

June 7, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

2MeSADP - Agonist pubchem gtoplig chembl_ligand gtoplig

PHYSIOLOGICAL LIGANDS

ATP, ADP



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number

segment

AA

Number
Generic
number
Hydrophobic TM3 R 122 3x50 G.H5 L 349 G.H5.20
Hydrophobic TM5 T 223 5x72 G.S6 Y 321 G.S6.02
Van-der-waals TM5 T 223 5x72 G.S6 Y 321 G.S6.02
Hydrophobic ICL2 P 129 - G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 129 - G.H5 I 345 G.H5.16
Hydrophobic TM7 L 301 7x56 G.H5 L 354 G.H5.25
Hydrophobic TM3 R 122 3x50 G.H5 L 354 G.H5.25
Hydrophobic ICL2 F 130 - G.H5 I 344 G.H5.15
Hydrophobic TM5 L 216 5x65 G.H5 K 346 G.H5.17
Polar H8 K 303 8x48 G.H5 F 355 G.H5.26
Hydrophobic TM5 L 216 5x65 G.H5 I 345 G.H5.16
Van-der-waals TM5 L 216 5x65 G.H5 I 345 G.H5.16
Hydrophobic TM2 F 59 2x39 G.H5 D 351 G.H5.22
Van-der-waals TM2 F 59 2x39 G.H5 D 351 G.H5.22
Ionic TM5 R 222 5x71 G.H5 D 338 G.H5.09
Polar TM5 R 222 5x71 G.H5 D 338 G.H5.09
Hydrophobic TM5 R 222 5x71 G.H5 D 338 G.H5.09
Van-der-waals TM3 T 126 3x54 G.H5 L 349 G.H5.20
Polar TM3 D 121 3x49 G.H5 C 352 G.H5.23
Van-der-waals TM3 D 121 3x49 G.H5 C 352 G.H5.23
Polar TM3 R 122 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 122 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 122 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM2 F 59 2x39 G.H5 C 352 G.H5.23
Van-der-waals TM2 F 59 2x39 G.H5 C 352 G.H5.23
Hydrophobic ICL2 T 132 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 T 132 - G.hns1 R 32 G.hns1.03
Hydrophobic TM4 P 135 4x36 G.HN R 24 G.HN.48
Van-der-waals TM4 P 135 4x36 G.HN R 24 G.HN.48
Aromatic ICL2 F 130 - G.H5 F 337 G.H5.08
Hydrophobic ICL2 F 130 - G.H5 F 337 G.H5.08
Van-der-waals ICL2 F 130 - G.H5 F 337 G.H5.08
Hydrophobic TM5 T 223 5x72 G.H5 D 338 G.H5.09
Van-der-waals TM5 T 223 5x72 G.H5 D 338 G.H5.09
Hydrophobic TM6 I 241 6x41 G.H5 L 354 G.H5.25
Hydrophobic TM3 K 125 3x53 G.H5 C 352 G.H5.23
Polar TM5 T 223 5x72 G.H5 D 342 G.H5.13
Hydrophobic TM5 T 223 5x72 G.H5 D 342 G.H5.13
Polar TM5 R 224 5x73 G.S6 I 320 G.S6.01
Hydrophobic TM5 R 224 5x73 G.S6 I 320 G.S6.01
Van-der-waals TM5 R 224 5x73 G.S6 I 320 G.S6.01
Hydrophobic TM6 V 234 6x34 G.H5 F 355 G.H5.26
Hydrophobic TM7 L 301 7x56 G.H5 G 353 G.H5.24
Van-der-waals TM7 L 301 7x56 G.H5 G 353 G.H5.24
Polar ICL4 C 302 - G.H5 F 355 G.H5.26
Hydrophobic ICL4 C 302 - G.H5 F 355 G.H5.26
Van-der-waals ICL4 C 302 - G.H5 F 355 G.H5.26
Hydrophobic TM3 T 126 3x54 G.H5 I 345 G.H5.16
Hydrophobic ICL2 F 130 - G.S3 L 195 G.S3.01
Van-der-waals ICL2 F 130 - G.S3 L 195 G.S3.01
Polar TM6 K 237 6x37 G.H5 L 354 G.H5.25
Hydrophobic TM6 K 237 6x37 G.H5 L 354 G.H5.25
Van-der-waals TM6 K 237 6x37 G.H5 L 354 G.H5.25
Hydrophobic TM5 I 212 5x61 G.H5 L 354 G.H5.25
Hydrophobic ICL2 P 129 - G.H5 I 344 G.H5.15
Van-der-waals ICL2 P 129 - G.H5 I 344 G.H5.15
Hydrophobic TM5 T 223 5x72 G.H5 A 339 G.H5.10
Aromatic TM5 R 224 5x73 G.S6 Y 321 G.S6.02
Polar TM3 K 125 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 K 125 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 K 125 3x53 G.H5 L 349 G.H5.20
Hydrophobic TM5 L 216 5x65 G.H5 L 349 G.H5.20
Polar ICL4 C 302 - G.H5 G 353 G.H5.24
Hydrophobic ICL4 C 302 - G.H5 G 353 G.H5.24
Van-der-waals ICL4 C 302 - G.H5 G 353 G.H5.24
Polar TM4 N 134 4x35 G.HN E 28 G.HN.52
Hydrophobic TM4 N 134 4x35 G.HN E 28 G.HN.52
Van-der-waals TM4 N 134 4x35 G.HN E 28 G.HN.52
Polar TM5 S 219 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM5 S 219 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 S 219 5x68 G.H5 D 342 G.H5.13
Polar ICL2 P 129 - G.H5 N 348 G.H5.19
Van-der-waals ICL2 P 129 - G.H5 N 348 G.H5.19
Hydrophobic ICL2 P 129 - G.H5 T 341 G.H5.12
Polar ICL4 C 302 - G.H5 K 350 G.H5.21
Van-der-waals ICL4 C 302 - G.H5 K 350 G.H5.21
Polar TM5 Y 220 5x69 G.H5 D 342 G.H5.13
Hydrophobic TM2 F 59 2x39 G.H5 G 353 G.H5.24
Hydrophobic ICL2 F 130 - G.H5 T 341 G.H5.12
Van-der-waals ICL2 F 130 - G.H5 T 341 G.H5.12
Hydrophobic TM5 T 223 5x72 G.H5 F 335 G.H5.06
Van-der-waals TM5 T 223 5x72 G.H5 F 335 G.H5.06