α2B-adrenoceptor - Go

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

6K41

RESOLUTION

2.9 Å

REFERENCE

10.1038/S41589-020-0492-2

PUBLICATION DATE

April 15, 2020

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

25 interactions (Click to see)

LIGANDS

dexmedetomidine - Agonist pubchem gtoplig chembl_ligand drugbank drug_central pubchem

PHYSIOLOGICAL LIGANDS

(-)-adrenaline, (-)-noradrenaline



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 R 365 6x29 G.H5 Y 354 G.H5.26
Aromatic TM6 R 365 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM6 R 365 6x29 G.H5 Y 354 G.H5.26
Van-der-waals TM6 R 365 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM5 S 202 5x68 G.H5 L 348 G.H5.20
Polar TM4 T 125 4x38 G.hns1 K 32 G.hns1.03
Polar ICL2 R 124 34x57 G.H5 N 347 G.H5.19
Polar TM3 A 113 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 113 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM6 V 372 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 372 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 A 117 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 A 117 34x50 G.H5 I 344 G.H5.16
Polar TM6 R 368 6x32 G.H5 G 352 G.H5.24
Hydrophobic TM5 I 195 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 195 5x61 G.H5 L 353 G.H5.25
Polar TM3 R 110 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 110 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 110 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 V 114 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 L 118 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 L 118 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM6 V 372 6x36 G.H5 G 352 G.H5.24
Van-der-waals TM6 V 372 6x36 G.H5 G 352 G.H5.24
Hydrophobic ICL2 L 118 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 L 118 34x51 G.H5 T 340 G.H5.12
Polar ICL2 S 122 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 S 122 34x55 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 S 122 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic TM4 T 125 4x38 G.HN I 28 G.HN.52
Hydrophobic TM5 I 198 5x64 G.H5 I 344 G.H5.16
Hydrophobic TM6 F 369 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 F 369 6x33 G.H5 L 353 G.H5.25
Ionic ICL1 R 41 12x48 G.h2s4 D 218 G.h2s4.03
Polar ICL1 R 41 12x48 G.h2s4 D 218 G.h2s4.03
Hydrophobic ICL2 A 117 34x50 G.H5 T 340 G.H5.12
Hydrophobic ICL2 L 118 34x51 G.H5 V 339 G.H5.11
Hydrophobic TM5 A 199 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 373 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM4 P 126 4x39 G.HN I 28 G.HN.52
Hydrophobic TM3 V 114 3x54 G.H5 N 347 G.H5.19
Hydrophobic ICL2 L 118 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 118 34x51 G.H5 I 343 G.H5.15
Hydrophobic ICL2 L 118 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 118 34x51 G.S3 L 195 G.S3.01
Polar ICL4 F 429 - G.H5 G 352 G.H5.24
Hydrophobic ICL4 F 429 - G.H5 G 352 G.H5.24
Polar TM6 R 365 6x29 G.h4s6 P 315 G.h4s6.09
Van-der-waals TM6 R 365 6x29 G.h4s6 P 315 G.h4s6.09