Structure information

α2B-adrenoceptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6K41

SPECIES

Homo sapiens

RESOLUTION

2.900

PREFERRED CHAIN

R

PUBLICATION DATE

April 15, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Dexmedetomidine V93 3.33x33 TM3 hydrophobic
Dexmedetomidine W384 6.48x48 TM6 hydrophobic
Dexmedetomidine F387 6.51x51 TM6 aromatic (face-to-edge)
Dexmedetomidine F388 6.52x52 TM6 aromatic (edge-to-face)
Dexmedetomidine F412 7.39x38 TM7 polar (hydrogen bond with backbone)
Dexmedetomidine Y416 7.43x42 TM7 aromatic (face-to-edge)

Ligands

Dexmedetomidine

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Residue Diagrams

A N G F I T F L I L F T I A A A I A A T 1 V S L A A A D I L V A L T I I P F S L A N 2 A C L H V I S S T C F L V D L A L Y V E 3 I K C I I L T V W L I A A V I S L P P L 4 Y V L I M I L C P A F F S G I S S A L I Y 5 A V V I G V F V L C W F P F F F S Y S L 6 V P N L S S N C Y G I W F F F Q F L G 7
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ICL1 R S L R ICL1ECL1 Y W Y F ECL1ICL2 A L E Y N S K R ICL2ECL2 Y K G D Q G P Q P R G R P Q C K L N Q ECL2ICL3 K G G P G Q G E S K Q P R P D H G G A L A S A K L P A L A S V A S A R E V N G H S K S T G E K E E G E T P E D T G T R A L P P S W A A L P N S G Q G Q K E G V C G A S P E D E A E E E E E E E E E E E E C E P Q A V P V S P A S A C S P P L Q Q P Q G S R V L A T L R G Q V L L G R G V G A I G G Q W W R R ICL3ECL3 P K H C K V ECL3N-term M D H Q D P Y S V Q N-termC-term R P W T Q T A W C-term A T A A I A A A I T F L I L F T I F G N A L V I L A V L T S A P Q N L F L V S L A A A D I L V A T L I I P F S L A N E L L G R R T W C E V Y L A L D V L F C T S S I V H L C A I S L D R Y W A V S R T P R R I K C I I L T V W L I A A V I S L P P L I E A W Y I L A S S I G S F F A P C L I M I L V Y L R I Y L I A K R S N R R G P R A R A Q L T R E K R F T F V L A V V I G V F V L C W F P F F F S Y S L G A I C P H G L F Q F F F W I G Y C N S S L N P V I Y T I F N Q D F R R F R R A I L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
α2B-adrenoceptor
TM3
3x33 3.33x33 V93
TM6
6x48 6.48x48 W384
6x51 6.51x51 F387
6x52 6.52x52 F388
TM7
7x38 7.39x38 F412
7x42 7.43x42 Y416