NTS1 receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.1 Å

REFERENCE

PUBLICATION DATE

June 3, 2026

3D VIEW

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LIGAND INTERACTIONS

LIGANDS

JMV449 - Agonist pubchem gtoplig

PHYSIOLOGICAL LIGANDS

large neuromedin N (Mouse), neurotensin (Human), neuromedin N (Human), large neuromedin N (Human), large neuromedin N (Rat), large neurotensin (Human), neuromedin N (Mouse)



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type
GPCR
Segment

AA

Number
Generic
number
Gα
segment

AA

Number
Generic
number
Hydrophobic TM4 R 184 4x41 G.HN R 24 G.HN.48
Van-der-waals TM4 R 184 4x41 G.HN R 24 G.HN.48
Polar TM6 R 294 6x26 G.H5 D 341 G.H5.13
Van-der-waals TM6 R 294 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM7 Y 364 7x53 G.H5 G 352 G.H5.24
Van-der-waals TM7 Y 364 7x53 G.H5 G 352 G.H5.24
Van-der-waals TM7 N 365 7x54 G.H5 F 354 G.H5.26
Polar TM3 R 166 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 166 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 166 3x50 G.H5 C 351 G.H5.23
Hydrophobic H8 R 372 8x51 G.h4s6 D 315 G.h4s6.09
Polar TM2 Q 98 2x36 G.H5 D 350 G.H5.22
Hydrophobic TM2 Q 98 2x36 G.H5 D 350 G.H5.22
Van-der-waals TM2 Q 98 2x36 G.H5 D 350 G.H5.22
Hydrophobic TM3 A 169 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 169 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM6 A 297 6x29 G.H5 L 348 G.H5.20
Hydrophobic H8 A 369 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 A 369 8x48 G.H5 F 354 G.H5.26
Hydrophobic TM6 L 298 6x30 G.H5 I 344 G.H5.16
Hydrophobic TM3 I 170 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM7 L 366 7x55 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 298 6x30 G.H5 L 348 G.H5.20
Hydrophobic TM3 H 172 3x56 G.HN E 28 G.HN.52
Van-der-waals TM3 H 172 3x56 G.HN E 28 G.HN.52