PDB
20ZL
Resolution
3.1 Å
Released
June 3, 2026
Receptor
NTS1
Class
A
Species
Homo sapiens
Ligand
JMV449
Function
Agonist
Reference
10.1038/S41586-026-10228-W

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Ligand Amino Acid Generic Number Segment Interaction Type
JMV449 L54 N-term Van der Waals
JMV449 L54 N-term polar (hydrogen bond with backbone)
JMV449 F127 2.65x64 TM2 hydrophobic
JMV449 F127 2.65x64 TM2 Van der Waals
JMV449 H131 ECL1 Van der Waals
JMV449 H131 ECL1 polar (hydrogen bond with backbone)
JMV449 H132 ECL1 Van der Waals
JMV449 Y145 3.29x29 TM3 Van der Waals
JMV449 Y145 3.29x29 TM3 polar (hydrogen bond)
JMV449 M207 ECL2 hydrophobic
JMV449 M207 ECL2 Van der Waals
JMV449 R212 ECL2 Van der Waals
JMV449 V223 ECL2 hydrophobic
JMV449 V223 ECL2 Van der Waals
JMV449 T225 45.51x51 ECL2 Van der Waals
JMV449 T225 45.51x51 ECL2 polar (hydrogen bond)
JMV449 I237 5.39x40 TM5 hydrophobic
JMV449 I237 5.39x40 TM5 Van der Waals
JMV449 R322 6.54x54 TM6 polar (charge-assisted hydrogen bond)
JMV449 R323 6.55x55 TM6 Van der Waals
JMV449 F326 6.58x58 TM6 Van der Waals
JMV449 F326 6.58x58 TM6 hydrophobic
JMV449 W334 ECL3 hydrophobic
JMV449 W334 ECL3 Van der Waals
JMV449 Y339 7.28x27 TM7 hydrophobic
JMV449 Y339 7.28x27 TM7 Van der Waals
JMV449 Y342 7.31x30 TM7 polar (hydrogen bond)
JMV449 Y342 7.31x30 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 K S L Q ICL1ECL1 H H P W A F ECL1ICL2 P F K A K T L M ICL2ECL2 G E Q N R S A D G Q H A G G L V C T P T I ECL2ICL3 Q V C T V G G E H S T F S M A I E ICL3ECL3 S D E Q W ECL3N-term M R L N S S A P G T P G T P A A D P F Q R A Q A G L E E A L L A P G F G N A S G N A S E R V L A A P S S E L D V N T N-termC-term P V W R R R R K R P A F S R K A D S V S S N H T L S S N A T R E T L Y C-term D I Y S K V L V T A V Y L A L F V V G T V G N T V T A F T L A R K S L Q S T V H Y H L G S L A L S D L L T L L L A M P V E L Y N F I W V G D A G C R G Y Y F L R D A C T Y A T A L N V A S L S V E R Y L A I C H S R S R T K K F I S A I W L A S A L L A V P M L F T M H T A T V K V V I Q V N T F M S F I F P M V V I S V L N T I I A N K L T V M V R Q A A E Q G P G R V Q A L R H G V R V L R A V V I A F V V C W L P Y H V R R L M F C Y I T P F L Y D F Y H Y F Y M V T N A L F Y V S S T I N P I L Y N L V S A N F L A L C F R H I T L A C
Helix box plot — Download: PNG | SVG T N G V T G V V F L A L Y V A T V L V K 1 G S L A L S D L L T L L L A M P V E L Y N 2 S A V N L A T A Y T C A D R L F Y Y G R 3 T K K F I S A I W L A S A L L A V P M 4 N L V S I V V M P F I F S M F T N V Q I V 5 R A V V I A F V V C W L P Y H V R R L M 6 I P N I T S S V Y F L A N T V M Y F Y 7

GPCRdb(A)
GPCRdb(A)
NTS1 receptor
TM2
2x64 2.65x64 F127
TM3
3x29 3.29x29 Y145
ECL2
45x51 45.51x51 T225
TM5
5x40 5.39x40 I237
TM6
6x54 6.54x54 R322
6x55 6.55x55 R323
6x58 6.58x58 F326
TM7
7x27 7.28x27 Y339
7x30 7.31x30 Y342