apelin receptor - Gi1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

G PROTEIN (FAMILY)

Gi/o

G PROTEIN SPECIES

Homo sapiens

PDB CODE

RESOLUTION

3.8 Å

REFERENCE

PUBLICATION DATE

July 27, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

apelin receptor early endogenous ligand - Agonist pubchem

ENDOGENOUS LIGANDS

apelin receptor early endogenous ligand, apelin-17, apelin-13, [Pyr1]apelin-13, Elabela/Toddler-21, Elabela/Toddler-32, apelin-36, Elabela/Toddler-11



GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

, , , GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

GPCR AA GPCR number GPCRdb# Segment G protein AA G protein number CGN# Interaction Type
R 127 3x50 TM3 L 353 G.H5.25 hydrophobic
R 127 3x50 TM3 L 353 G.H5.25 van-der-waals
I 131 3x54 TM3 L 348 G.H5.20 hydrophobic
I 131 3x54 TM3 L 348 G.H5.20 van-der-waals
K 242 6x29 TM6 F 354 G.H5.26 van-der-waals
K 242 6x29 TM6 L 353 G.H5.25 polar
R 245 6x32 TM6 F 354 G.H5.26 polar
I 131 3x54 TM3 C 351 G.H5.23 hydrophobic
H 231 5x68 TM5 I 344 G.H5.16 hydrophobic
P 314 - ICL4 F 354 G.H5.26 hydrophobic
P 314 - ICL4 F 354 G.H5.26 van-der-waals
I 131 3x54 TM3 I 344 G.H5.16 hydrophobic
F 312 - ICL4 F 354 G.H5.26 hydrophobic
R 315 8x49 H8 F 354 G.H5.26 hydrophobic
R 315 8x49 H8 F 354 G.H5.26 van-der-waals
R 62 - ICL1 D 350 G.H5.22 ionic
R 62 - ICL1 D 350 G.H5.22 polar
F 232 5x69 TM5 K 345 G.H5.17 hydrophobic
F 232 5x69 TM5 K 345 G.H5.17 van-der-waals
F 312 - ICL4 L 353 G.H5.25 hydrophobic
F 312 - ICL4 L 353 G.H5.25 van-der-waals
R 139 - ICL2 R 32 G.hns1.03 van-der-waals